Navigation Links
Mutant Mouse Gene Offers Clues to Hearing Loss
Date:10/31/2008

Variant prevented ear hair cells from pumping out excess calcium, study finds

FRIDAY, Oct. 31 (HealthDay News) -- A mutation in mice that mimics progressive hearing loss in humans has been identified by European researchers.

They found that mice with a mutation in a gene called Oblivion had problems with the function of hair cells in the inner ear. In mice with one mutant copy of the Oblivion gene, ear hair cells showed some initial function but later degenerated. In mice with two mutant copies of the gene, the ear hair cells were damaged at birth.

"When we mapped the mutation to the mouse genome, we quickly found a probable cause for hearing loss," study senior author Karen Steel, of the Wellcome Trust Sanger Institute in Cambridge, U.K., said in an institute news release.

"We showed that the mutant mice carried a change in one letter of their genetic code in a gene called Atp2b2. Changing a specific C to a T in this gene stops it from producing a normal molecular pump that is needed to keep hair cells in the ear working efficiently by pumping excess calcium out of the cell."

The study was published online Oct. 31 in PLoS Genetics.

Other mutations have been identified, but the Oblivion gene mutation is unique in the way it causes hearing loss due to mutations in Atp2b2, a gene that's previously been linked to hearing loss in humans.

"Our aim of identifying and characterizing mice with impaired hearing is to help us to understand the biology of this remarkable sense," Steel said. "Improving our understanding of the molecular and cellular action of genetic variants will help us to develop improved diagnostics and improved treatments for humans."

Progressive hearing loss affects about 60 percent of people over age 70. Environmental causes can contribute to this hearing loss, but genetics also play a major role.

More information

The National Institute on Deafness and Other Communication Disorders has more about hearing loss.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Oct. 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. What is the more suitable for early detection of low abundant lamivudine-resistant mutants?
2. FSU researchers mutant proteins could lead to new treatment for heart disease
3. Mutant gene causes epilepsy, intellectual disability in women
4. Effect of mutant p53 stability on tumorigenesis and drug design
5. Intrabody can mop up mutant protein in Huntingtons disease model
6. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
7. Mouse vision has a rhythm all its own
8. Mouse Study Gives Clues to Colitis
9. Mouse mammary tumor virus can replicate in human cells
10. A longer-living, healthier mouse that could hold clues to human aging
11. Gene Tweak Reverses Aging in Mouse Skin Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Mouse Gene Offers Clues to Hearing Loss
(Date:2/13/2016)... ... 13, 2016 , ... Christie Medical Holdings, Inc. presented the ... VeinViewer® Vision vein finder for the nursing school simulation lab. This ... draw blood, combining technology with traditional technique. , “VeinViewer is a wonderful new ...
(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” stage of a ... go out of their way to be romantic, and may exaggerate a strength or ... any online dating profile. , A recent study from Queendom.com , however, ...
(Date:2/12/2016)... Angeles, CA (PRWEB) , ... February 12, 2016 , ... ... Vinci-assisted hernia surgeries are beginning to account for a significant portion of hernia repairs ... Shirin Towfigh of the Beverly Hills Hernia Center notes that this trend has not ...
(Date:2/12/2016)... ... 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett ... of these scholarships is to encourage applicants to pursue a degree in their field ... two parishes. , “We have available jobs in St. Landry and Evangeline Parishes ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... over 250 members of South Florida’s philanthropic community at its 10th anniversary Fashion ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... SAN DIEGO and SEOUL, ... -- Silicon Biosys­tems Menarini and Macrogen, Inc. today ... clinical assays and innovative procedures for precision medicine ... to combine Silicon Biosystems, DEPArray™ digital-sorting technology with ... development of tests certified under the Clinical Laboratory ...
(Date:2/12/2016)... , Feb. 12, 2016  Apellis ... completed a $47.1 million Series D preferred ... Asset Management, Hillhouse Capital Group and venBio ... Venture Investments, AJU IB Investment, and Epidarex ... used to further advance clinical trials in ...
(Date:2/11/2016)... 2016 Stem cells are primitive cells found ... and the capacity to differentiate into mature cell types ... the first mouse embryonic stem cells were derived from ... that the first culturing of embryonic stem cells from ... produced until 2006 As a result of these discoveries, ...
Breaking Medicine Technology: