Navigation Links
Mutant Mouse Gene Offers Clues to Hearing Loss
Date:10/31/2008

Variant prevented ear hair cells from pumping out excess calcium, study finds

FRIDAY, Oct. 31 (HealthDay News) -- A mutation in mice that mimics progressive hearing loss in humans has been identified by European researchers.

They found that mice with a mutation in a gene called Oblivion had problems with the function of hair cells in the inner ear. In mice with one mutant copy of the Oblivion gene, ear hair cells showed some initial function but later degenerated. In mice with two mutant copies of the gene, the ear hair cells were damaged at birth.

"When we mapped the mutation to the mouse genome, we quickly found a probable cause for hearing loss," study senior author Karen Steel, of the Wellcome Trust Sanger Institute in Cambridge, U.K., said in an institute news release.

"We showed that the mutant mice carried a change in one letter of their genetic code in a gene called Atp2b2. Changing a specific C to a T in this gene stops it from producing a normal molecular pump that is needed to keep hair cells in the ear working efficiently by pumping excess calcium out of the cell."

The study was published online Oct. 31 in PLoS Genetics.

Other mutations have been identified, but the Oblivion gene mutation is unique in the way it causes hearing loss due to mutations in Atp2b2, a gene that's previously been linked to hearing loss in humans.

"Our aim of identifying and characterizing mice with impaired hearing is to help us to understand the biology of this remarkable sense," Steel said. "Improving our understanding of the molecular and cellular action of genetic variants will help us to develop improved diagnostics and improved treatments for humans."

Progressive hearing loss affects about 60 percent of people over age 70. Environmental causes can contribute to this hearing loss, but genetics also play a major role.

More information

The National Institute on Deafness and Other Communication Disorders has more about hearing loss.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Oct. 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. What is the more suitable for early detection of low abundant lamivudine-resistant mutants?
2. FSU researchers mutant proteins could lead to new treatment for heart disease
3. Mutant gene causes epilepsy, intellectual disability in women
4. Effect of mutant p53 stability on tumorigenesis and drug design
5. Intrabody can mop up mutant protein in Huntingtons disease model
6. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
7. Mouse vision has a rhythm all its own
8. Mouse Study Gives Clues to Colitis
9. Mouse mammary tumor virus can replicate in human cells
10. A longer-living, healthier mouse that could hold clues to human aging
11. Gene Tweak Reverses Aging in Mouse Skin Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Mouse Gene Offers Clues to Hearing Loss
(Date:8/23/2017)... ... August 23, 2017 , ... ... (SNAC) is holding an inaugural State of the Science Symposium in partnership with ... Sept. 20, 2017. , This symposium provides a forum for global leaders in ...
(Date:8/22/2017)... ... August 22, 2017 , ... Western North Carolina’s only certified ... international aesthetics conference for medical professionals about the positive impact Juliet™ feminine ... growing practice. , Dr. George K. Ibrahim shared the results of ...
(Date:8/22/2017)... ... August 22, 2017 , ... Nurses at Apple Rehab Watch ... Cove, recently received training and certification in Closed Pulse Irrigation™ (CPI) for ... five-star rating from the Centers for Medicare and Medicaid Services, to have a CPI ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... heart-wrenching story of child abuse and neglect, and the struggles faced while hoping ... is the creation of published author, Judy Von Bernewitz, who spent 13 years ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a ... fight Fatigue . , As the stress of modern life continually makes more demands ... Constant use of artificial stimulants can trap people in vicious high/low cycles and can ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... -- Endo International plc (NASDAQ: ENDP ) today ... known U.S. mesh product liability claims and that it ... U.S. claims at reasonable values. Under the agreements, Endo ... of 2017 and continuing through the fourth quarter of ... the Company intends to increase its mesh product liability ...
(Date:8/2/2017)... Fenita J. Caldwell is ... Lifetime Professional in the Field of Healthcare. Caldwell ... Pharmaceuticals, AG. Her skills and areas of expertise ... Fenita ... experience as a highly successful sales specialist in ...
(Date:8/1/2017)... Aug. 1, 2017   CerSci Therapeutics , a ... Texas , has received notice from the National ... of Health (NIH) that it has been awarded a ... over $650,000 in 2017 with an additional $1,000,000 to ... New Drug application of their lead non-opioid drug candidate ...
Breaking Medicine Technology: