Navigation Links
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study
Date:8/8/2014

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Researchers have pinpointed a gene mutation that causes a potentially deadly heart condition in Newfoundland dogs.

The inherited condition -- called subvalvular aortic stenosis (SAS) -- also affects children and other dog breeds. Surgery can correct the problem in children, but not in dogs, the researchers noted.

In dogs, SAS shows up in the heart as a ridge or ring of abnormal tissue growth below the aortic valve that restricts blood flow from the heart into the aorta. The condition can cause fainting, sudden collapse, irregular heart rate or sudden death.

Dogs with mild SAS can have a normal lifespan, but those with the severe form are likely to die before they are 4.5 years old, even if they receive medications.

The researchers identified the gene mutation associated with canine SAS after analyzing thousands of genes in Newfoundland dogs. The mutation occurs in a gene called PICALM, according to the study published recently in the journal Human Genetics.

The same gene mutation has been linked to the formation of plaque-like lesions in the brains of people with Alzheimer's disease, according to study leader Dr. Joshua Stern, a veterinary cardiologist at the University of California, Davis.

"Our hope now is that breeders will be able to make informed breeding decisions and avoid breeding dogs that harbor this mutation, thus gradually eliminating the disease from the Newfoundland breed," Stern said in a university news release.

"In addition, now that we know one gene is responsible for SAS and more about which proteins are involved, we can move forward to consider novel therapies that may help treat this devastating condition," he added.

More information

The U.S. National Library of Medicine has more about congenital heart defects in people.

SOURCE: University of California, Davis, news release, Aug. 5, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
2. Drug combination against NRAS-mutant melanoma discovered
3. Genomic sequencing identifies mutant drivers of common brain tumor
4. Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor models
5. PD-like sleep and motor problems observed in α-synuclein mutant mice
6. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
7. Standard radiation therapy dose provides pain relief for painful heel spurs
8. Fatal bridge collapse spurs new, affordable, instant warnings
9. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
10. Oxygen Therapy Spurs Recovery in Some Stroke Patients
11. Public Funding Spurs Couples to Seek Fertility Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study 
(Date:12/2/2016)... Raleigh, NC (PRWEB) , ... December 02, 2016 , ... ... the Open Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare ... plan (Part C) or prescription drug plan (Part D) need to make changes during ...
(Date:12/2/2016)... New York, NY (PRWEB) , ... December 02, ... ... today, featuring an inspirational interview of two ostomy patients, standing as living proof ... million people suffer from digestive diseases and issues that spike around the holidays. ...
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet ... in USA Today, which covers the innovative treatments, therapeutic technologies, and revolutionized nutrition ... lives. “We are prolonging life 6 years in the last 3 decades,” says ...
(Date:12/2/2016)... ... 02, 2016 , ... Universal Medical Systems, Inc. (UMS) the ... company to offer robotic imaging to veterinary medicine is sponsoring the appearance of ... the American Association of Equine Practitioners 62nd Annual Convention from December 4-6, 2016 ...
(Date:12/2/2016)... , ... December 02, 2016 , ... Yisrayl Hawkins, at ... into how this current generation fits into Bible Prophecy. Yisrayl says this generation, known ... pointing to this conclusion, showing how the details line up exactly with Bible Prophecy ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)...  PipelineRx, a leading medication management technology company ... of its SaaS-based telepharmacy platform, PowerGridRx™ , ... Midyear Clinical Meeting and Exhibition, December 5-7 in ... 300 hospital clients nationally, the Company is a ... dramatically improve pharmacy operations, enhance patient safety, and ...
(Date:12/2/2016)... 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today announced ... ("PSI").  The combination of Texas -based Maxor ... PSI bring together both company,s clinical expertise and high-touch patient ... industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... 2, 2016 Lianluo Smart Limited (Nasdaq: ... Company") which develops, markets and sells medical devices ... China and international markets, recently attended ... Treatment New Progress Forum, co-hosted by the Institute ... , Guangdong Provincial People,s Hospital and Cardiology ...
Breaking Medicine Technology: