Navigation Links
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study
Date:8/8/2014

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Researchers have pinpointed a gene mutation that causes a potentially deadly heart condition in Newfoundland dogs.

The inherited condition -- called subvalvular aortic stenosis (SAS) -- also affects children and other dog breeds. Surgery can correct the problem in children, but not in dogs, the researchers noted.

In dogs, SAS shows up in the heart as a ridge or ring of abnormal tissue growth below the aortic valve that restricts blood flow from the heart into the aorta. The condition can cause fainting, sudden collapse, irregular heart rate or sudden death.

Dogs with mild SAS can have a normal lifespan, but those with the severe form are likely to die before they are 4.5 years old, even if they receive medications.

The researchers identified the gene mutation associated with canine SAS after analyzing thousands of genes in Newfoundland dogs. The mutation occurs in a gene called PICALM, according to the study published recently in the journal Human Genetics.

The same gene mutation has been linked to the formation of plaque-like lesions in the brains of people with Alzheimer's disease, according to study leader Dr. Joshua Stern, a veterinary cardiologist at the University of California, Davis.

"Our hope now is that breeders will be able to make informed breeding decisions and avoid breeding dogs that harbor this mutation, thus gradually eliminating the disease from the Newfoundland breed," Stern said in a university news release.

"In addition, now that we know one gene is responsible for SAS and more about which proteins are involved, we can move forward to consider novel therapies that may help treat this devastating condition," he added.

More information

The U.S. National Library of Medicine has more about congenital heart defects in people.

SOURCE: University of California, Davis, news release, Aug. 5, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
2. Drug combination against NRAS-mutant melanoma discovered
3. Genomic sequencing identifies mutant drivers of common brain tumor
4. Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor models
5. PD-like sleep and motor problems observed in α-synuclein mutant mice
6. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
7. Standard radiation therapy dose provides pain relief for painful heel spurs
8. Fatal bridge collapse spurs new, affordable, instant warnings
9. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
10. Oxygen Therapy Spurs Recovery in Some Stroke Patients
11. Public Funding Spurs Couples to Seek Fertility Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study 
(Date:8/23/2017)... ... August 23, 2017 , ... TSC Advantage has been ... Risk Management Solution Innovations and Security Solution for Government Innovations. Both gold awards ... and its DHS SAFETY Act-designated enterprise security assessment approach. , The ninth annual ...
(Date:8/23/2017)... ... August 23, 2017 , ... The non-profit ... holding an inaugural State of the Science Symposium in partnership with the Global ... 2017. , This symposium provides a forum for global leaders in human nutrition ...
(Date:8/22/2017)... ... August 22, 2017 , ... The Women’s Choice Award, a ... Migraine Relief with the 2017 Women’s Choice Award. The identification by women of an ... out of 4 migraine sufferers are women. In a survey taken by the Women’s ...
(Date:8/22/2017)... ... August 22, 2017 , ... Western ... spoke at a popular international aesthetics conference for medical professionals about the positive ... patients’ health and his growing practice. , Dr. George K. Ibrahim ...
(Date:8/22/2017)... ... August 22, 2017 , ... Each of the past six years, Lightning Labels has sent ... these labels and stickers, demonstrating the variety and creativity of their designs. Submissions this year ... came in. Now, it's time to announce the winners of the sixth annual Photo Contest, ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... president, effective Aug. 7, 2017. ... other interests and will serve as president emeritus during a ... us in multiple leadership roles since he joined Diplomat with ... has provided decisive, strategic leadership which continues to benefit our ...
(Date:8/7/2017)... , Aug. 7, 2017  Endo International plc (NASDAQ: ... agreements to resolve virtually all known U.S. mesh product ... to resolve the known remaining U.S. claims at reasonable ... beginning in the fourth quarter of 2017 and continuing ... its second quarter 2017 results, the Company intends to ...
(Date:8/4/2017)... 3, 2017  Agragen, LLC, a ... the biopharmaceutical, nutraceutical, and aquacultural feed sectors, announces ... lead drug candidates, AGR131.  This drug is designed ... the blood of patients suffering from inflammatory conditions ... disease. Biological ...
Breaking Medicine Technology: