Navigation Links
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study
Date:8/8/2014

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Researchers have pinpointed a gene mutation that causes a potentially deadly heart condition in Newfoundland dogs.

The inherited condition -- called subvalvular aortic stenosis (SAS) -- also affects children and other dog breeds. Surgery can correct the problem in children, but not in dogs, the researchers noted.

In dogs, SAS shows up in the heart as a ridge or ring of abnormal tissue growth below the aortic valve that restricts blood flow from the heart into the aorta. The condition can cause fainting, sudden collapse, irregular heart rate or sudden death.

Dogs with mild SAS can have a normal lifespan, but those with the severe form are likely to die before they are 4.5 years old, even if they receive medications.

The researchers identified the gene mutation associated with canine SAS after analyzing thousands of genes in Newfoundland dogs. The mutation occurs in a gene called PICALM, according to the study published recently in the journal Human Genetics.

The same gene mutation has been linked to the formation of plaque-like lesions in the brains of people with Alzheimer's disease, according to study leader Dr. Joshua Stern, a veterinary cardiologist at the University of California, Davis.

"Our hope now is that breeders will be able to make informed breeding decisions and avoid breeding dogs that harbor this mutation, thus gradually eliminating the disease from the Newfoundland breed," Stern said in a university news release.

"In addition, now that we know one gene is responsible for SAS and more about which proteins are involved, we can move forward to consider novel therapies that may help treat this devastating condition," he added.

More information

The U.S. National Library of Medicine has more about congenital heart defects in people.

SOURCE: University of California, Davis, news release, Aug. 5, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
2. Drug combination against NRAS-mutant melanoma discovered
3. Genomic sequencing identifies mutant drivers of common brain tumor
4. Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor models
5. PD-like sleep and motor problems observed in α-synuclein mutant mice
6. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
7. Standard radiation therapy dose provides pain relief for painful heel spurs
8. Fatal bridge collapse spurs new, affordable, instant warnings
9. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
10. Oxygen Therapy Spurs Recovery in Some Stroke Patients
11. Public Funding Spurs Couples to Seek Fertility Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study 
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... PARIS and NEW YORK , Sept. 12, ... ethical performance ratings for global supply chains, has published the first annual ... the CSR performance of more than 20,400 companies evaluated by EcoVadis, based ... years 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: