Navigation Links
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study
Date:8/8/2014

FRIDAY, Aug. 8, 2014 (HealthDay News) -- Researchers have pinpointed a gene mutation that causes a potentially deadly heart condition in Newfoundland dogs.

The inherited condition -- called subvalvular aortic stenosis (SAS) -- also affects children and other dog breeds. Surgery can correct the problem in children, but not in dogs, the researchers noted.

In dogs, SAS shows up in the heart as a ridge or ring of abnormal tissue growth below the aortic valve that restricts blood flow from the heart into the aorta. The condition can cause fainting, sudden collapse, irregular heart rate or sudden death.

Dogs with mild SAS can have a normal lifespan, but those with the severe form are likely to die before they are 4.5 years old, even if they receive medications.

The researchers identified the gene mutation associated with canine SAS after analyzing thousands of genes in Newfoundland dogs. The mutation occurs in a gene called PICALM, according to the study published recently in the journal Human Genetics.

The same gene mutation has been linked to the formation of plaque-like lesions in the brains of people with Alzheimer's disease, according to study leader Dr. Joshua Stern, a veterinary cardiologist at the University of California, Davis.

"Our hope now is that breeders will be able to make informed breeding decisions and avoid breeding dogs that harbor this mutation, thus gradually eliminating the disease from the Newfoundland breed," Stern said in a university news release.

"In addition, now that we know one gene is responsible for SAS and more about which proteins are involved, we can move forward to consider novel therapies that may help treat this devastating condition," he added.

More information

The U.S. National Library of Medicine has more about congenital heart defects in people.

'/>"/>

Copyright©2014 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
2. Drug combination against NRAS-mutant melanoma discovered
3. Genomic sequencing identifies mutant drivers of common brain tumor
4. Agios research demonstrates the effects of mutant IDH1 and IDH2 inhibitors in primary tumor models
5. PD-like sleep and motor problems observed in α-synuclein mutant mice
6. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
7. Standard radiation therapy dose provides pain relief for painful heel spurs
8. Fatal bridge collapse spurs new, affordable, instant warnings
9. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
10. Oxygen Therapy Spurs Recovery in Some Stroke Patients
11. Public Funding Spurs Couples to Seek Fertility Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutant Gene Spurs Dangerous Heart Condition in Newfoundland Dogs: Study 
(Date:7/3/2015)... ... July 03, 2015 , ... ... registration for a new SEO training system called "Page One Engine" . ... traffic generation has received glowing reviews from several well-known marketers. HonestyFirstReviews.com's Tiffany Hendricks ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... its 2015 Annual Conference , the premiere continuing education and networking ... Orlando at SeaWorld in Orlando, Florida. Speakers include the leading rheumatology experts ...
(Date:7/3/2015)... ... ... Scientists at several top US cancer centers believe they now know why ... here to read the complete story , just posted on the Surviving Mesothelioma website. ... and New York University exposed mice with a mutation on the tumor suppressor gene ...
(Date:7/3/2015)... ... ... Renowned rhinoplasty surgeon and Symposium Chairman, Dr. Rod J. Rohrich ... be held from March 4th - 6th, the 2016 (a previous announcement had stated ... Designed to take participants from the basic training and fundamentals of nasal surgery through ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. ... has been retained to lead a national president recruitment for Regional ... the healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare ...
Breaking Medicine News(10 mins):Health News:Page One Engine - Review Of Dori Friend's SEO Training Course Released 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Study Finds Small Amounts of Asbestos May Trigger Mesothelioma in People with Genetic Mutation, According to Surviving Mesothelioma 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces the Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3
... Senate to Quickly Pass this Important Lifesaving LegislationWASHINGTON, ... American Lung Association President and CEO:Today in Washington, ... favor with a strong bipartisan majority for the ... Family Smoking Prevention and Tobacco Control Act (HR ...
... The California Association of Health Plans (CAHP) is ... Awareness Day by increasing awareness about the wide ... for autism."California health plans understand the inherent challenges ... mental health conditions," said CAHP Interim President Charles ...
... (omega-3s), namely EPA and DHA found in seafood and ... benefits, but evidence of other benefits continues to stack ... menopausal women and healthier weight loss in obese dieters ... these topics are summarized in the March 2009 ...
... Excess amounts of a naturally fluorescent molecule found in ... for cancer, according to bioengineers. , NADH, or nicotinamide ... molecule necessary for the functioning of an enzyme -- ... power plant, or mitochondria. It fuels a series of ...
... Varian Medical Systems (NYSE: VAR ) today ... growth and innovation in life-saving technology utilizing X-ray energy ... , Varian Medical Systems emerged as a ... of Varian Associates, a 51-year-old Silicon Valley pioneer, into ...
... Take Place on May 2; ... Follow on May 9 LOS ANGELES, April 2 Revlon (NYSE: ... spokeswomen Jennifer Connelly and Jessica Alba along with NBC late night ... in New York taking place on Saturday, May 2, 2009 , ...
Cached Medicine News:Health News:U.S. House of Representatives Again Votes with a Strong Bipartisan Majority in Favor of Granting the U.S. FDA Regulatory Control Over Tobacco Products 2Health News:California Association of Health Plans Recognizes World Autism Awareness Day by Highlighting Medical Services Plans Provide 2Health News:Omega-3s May Benefit Newborns, Menopausal Women and Obese Individuals 2Health News:Naturally fluorescent molecules may serve as cancer biomarker 2Health News:Naturally fluorescent molecules may serve as cancer biomarker 3Health News:Varian Medical Systems to Celebrate Tenth Anniversary and Decade of Growth 2Health News:Varian Medical Systems to Celebrate Tenth Anniversary and Decade of Growth 3Health News:Jessica Alba, Christina Applegate, Jennifer Connelly, Miley Cyrus & Jimmy Fallon on Board to Host Entertainment Industry Foundation's 2009 Revlon Run/Walk 2Health News:Jessica Alba, Christina Applegate, Jennifer Connelly, Miley Cyrus & Jimmy Fallon on Board to Host Entertainment Industry Foundation's 2009 Revlon Run/Walk 3Health News:Jessica Alba, Christina Applegate, Jennifer Connelly, Miley Cyrus & Jimmy Fallon on Board to Host Entertainment Industry Foundation's 2009 Revlon Run/Walk 4
(Date:7/2/2015)... and VANCOUVER , July 2, ... (TSX-V: EPI) announced today that its common shares have been ... ("NASDAQ") under the symbol "EPIX". ESSA will begin ... retain its listing on the TSX Venture Exchange under the ... of the common shares on the NASDAQ, each of the ...
(Date:7/2/2015)...  New product launches are critical events for the ... thought leaders about new products, Medical Affairs is one ... a new therapy performs at launch. ... leader Best Practices, LLC, critical aspects of launch support ... early stage thought leader (TL) interaction, successful TL targeting, ...
(Date:7/2/2015)... July 2, 2015  Before you head outdoors with your ... can stay safe and healthy. Take steps to protect yourself ... http://nyackhospital.org/summersafety Protect Your Skin From the Sun ... can increase your risk of skin cancer. To protect your ... as possible, especially during midday hours. Wear a hat with ...
Breaking Medicine Technology:ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4Medical Affairs Role in Thought Leader Education is Key Success Factor for New Product Launches in the Pharmaceutical Industry 2First Aid Summer Survival Tips from Nyack Hospital 2First Aid Summer Survival Tips from Nyack Hospital 3
... ORLEANS, Oct. 19 NCPA 111th Annual Convention -- ... targeted pharmacy-based patient care services, has announced the launch ... Community Pharmacists Association,s annual convention, MirixaEdge enables pharmacists to ... their patients regardless of health plan, employer, or age. ...
... PARK, N.J., Oct. 19 As previously announced, WebMD Health Corp. ... will be holding their Annual Meetings of Stockholders beginning at 9:30 ... A live audio webcast of the meetings will be available over ... investors can go to www.wbmd.com (in the Investor Relations ...
Cached Medicine Technology:Mirixa Corporation Announces MirixaEdge(SM) 2WebMD and HLTH Corporation to Webcast Annual Meetings of Stockholders 2
... PRECISION represents a major advance ... be,tightly focused to cover pain. This ... where you need it, anywhere along ... of independent current sources for each ...
Used for traversing and exploring urethral strictures. The malleable tip can be shaped to desired configuration. The proximal end is threaded to attach to standard followers. Supplied sterile in peel...
Used to dilate the male or female urethra to treat stricture disease. Supplied sterile in peel-open packages. Intended for one-time use....
The balloon catheter is designed to pass over a previously placed .015 inch diameter wire guide included. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: