Navigation Links
Mussel-inspired 'glue' for surgical repair and cancer drug delivery

When it comes to sticking power under wet conditions, marine mussels are hard to beat. They can adhere to virtually all inorganic and organic surfaces, sustaining their tenacious bonds in saltwater, including turbulent tidal environments.

Northwestern University's Phillip B. Messersmith will discuss his research in a talk titled "Mussel-Inspired Materials for Surgical Repair and Drug Delivery" at the American Association for the Advancement of Science (AAAS) annual meeting in Boston. His presentation is part of the symposium "Translation of Mussel Adhesion to Beneficial New Concepts and Materials" to be held from 8:30 to 11:30 a.m. Saturday, Feb. 16.

Messersmith also will participate in a news briefing, titled "Mussel-Bound Adhesion," to be held at noon the same day.

He has created new materials that mimic mussel adhesive proteins for three medical applications: sealants for fetal membrane repair, self-setting antibacterial hydrogels, and polymers for cancer drug delivery and thermal destruction of cancer cells.

"Mussel adhesion is a remarkable process involving secretion of liquid protein glue that hardens rapidly into a solid, water-resistant adhesive," Messersmith said. "Several aspects of this process inspire our development of synthetic materials for practical applications. An unusually compelling opportunity for translation of mussel-adhesion concepts is in the repair or reconstruction of tissues in the human body, where water is ubiquitous and its presence represents a challenge for achieving desired outcomes."

Messersmith is a professor of biomedical engineering at Northwestern's McCormick School of Engineering and Applied Science.

The foot of the common mussel (Mytilus edulis) produces a sticky glue for adhering to rocks and other objects. Key to its adhesiveness is a family of unique proteins called mussel adhesive proteins, which contain a high concentration of the catecholic amino acid DOPA (dihydroxyphenylalanine).

All of Messersmith's biomedical materials contain a synthetic form of DOPA. (He first developed a simple synthetic polymer containing DOPA in 2002.) In his AAAS talk, Messersmith will detail these three medical applications of his materials:

  • Fetal membrane repair. Premature rupture of fetal membranes can occur spontaneously or in association with a surgical procedure. The membranes have limited ability to heal from these ruptures, and the situation often leads to early labor, premature birth and other serious complications. Messersmith's synthetic polymer is formulated as a rapidly solidifying liquid glue that adheres to the wet tissue and seals fetal membrane defects. His group is collaborating with researchers in Europe to conduct in-vivo testing of their mussel-inspired medical sealants for fetal membrane repair.

  • Self-setting antibacterial hydrogels. Silver ions possess antibacterial activity at low concentrations, and this has led to interest in incorporating silver into medical devices. Messersmith employs silver both to induce hydrogel cross-linking via catechol oxidation and as a precursor for silver nanoparticle formation. The silver nanoparticles then become embedded within the hydrogel structure, releasing silver ions to produce an antibacterial effect.

  • Cancer drug delivery and destruction removal of cancer cells. One of Messersmith's polymer designs forms pH-sensitive drug delivery vehicles that are stable and inactive in the bloodstream but are activated in the acidic tumor environment, which liberates the drug. A second design involves modifying the surface of gold nanorods with a mussel-inspired polymer coating, which helps the nanorods target cancer cells. Once at the target, the nanorods are irradiated with near-infrared light to produce highly localized heating that thermally destroys cancer cells.


Contact: Megan Fellman
Northwestern University

Related medicine news :

1. In children born with severe heart defect, surgical management has little effect on neuro outcomes
2. Nonsurgical Method to Measure Brain Pressure Shows Promise
3. Study examines medicare use for Mohs micrographic surgery and surgical excision for skin cancer
4. New surgical technique for removing inoperable tumors of the abdomen
5. Surgical excision unnecessary in some patients with benign papillomas
6. Boston researcher, surgical oncologist receives national award
7. Surgical removal of abdominal fat reduces skin cancer in mice
8. Surgical Residents Often Fatigued, Study Confirms
9. Study finds Massachusetts health reform leads to increased inpatient surgical procedures
10. Surgical sling reduces risk of weakened bladder control after prolapse surgery, U-M study says
11. DRE Medical Equipment Unveils FX-300+ Surgical Headlight and Light Source
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: