Navigation Links
Mushrooms may aid rapid vaccine response
Date:11/19/2007

A rapid production of therapeutic human drugs using modified mushrooms may help mount a quicker response to various public health problems, according to plant pathologists who have received a federal grant to perfect their technique.

C. Peter Romaine, professor of plant pathology at Penn State and holder of the John B. Swayne Chair in Spawn Science, said, "We are looking to address several public health issues through our research."

Romaine and his colleague, Xi Chen, previously a post-doctoral scholar at Penn State, hold the patent to genetically modify Agaricus bisporus the button variety of mushroom, which is the predominant edible species worldwide.

The Defense Advanced Research Projects Agency (DARPA) recently awarded Penn State and Agarigen Inc., Romaine's spin-off company based in Research Triangle Park in Raleigh, N.C., $2.2 million in initial funding under the Accelerated Manufacture of Pharmaceuticals (AMP) program for the rapid production of vaccines and other therapeutic proteins in altered mushrooms. The total value of the effort, if both phases of the development program are completed, could be up to $5.9 million.

"Our immediate research goals are to maximize the level of expression of various biopharmaceuticals and to devise efficient and economical methods for their extraction and purification from mushroom tissue," Romaine said.

At the end of the second year of the contract, Romaine and his colleagues, who include Agarigen cofounder and former Penn State graduate Dr. Donald S. Walters, Penn State post doctoral associate Dr. Carl Schlagnhaufer and a team of nine Agarigen scientists, are expected to demonstrate an ability to produce vaccines or other biological drugs within 12 weeks.

"It will be a blind test," said Romaine. "We will be handed genes for vaccines, monoclonal antibodies or other therapeutic proteins, and asked to produce them in the mushroom."

The drugs will then be extracted from the mushroom into forms that could be administered to people. In a pending third year of the project, the researchers are expected to show they can execute a full-scale manufacturing effort and produce three million doses of a drug in 12 weeks.

Researchers at Penn State and Agarigen are currently focusing on assembling gene components for expression in the mushroom, and fine-tuning their techniques to ensure a consistently high level and quality of the drug.

"We are evaluating different gene sequences from a broad array of organisms to determine which provide us the highest level of drug expression in the mushroom," explained Romaine. "It is an empirical process, but we are leaving no stone unturned to achieve our end goal."


'/>"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. Study documents rapid increase in youth bipolar disorder diagnoses
2. Rates of bipolar diagnosis in youth rapidly climbing, treatment patterns similar to adults
3. Health Insurance Premiums Rise 6.1 Percent in 2007, Less Rapidly Than in Recent Years But Still Faster Than Wages and Inflation
4. RESolutions Rapid Enrollment Solutions, LLC Mobilizes Team of Regional Recruitment Specialists(TM)
5. Siemens Medical Solutions Diagnostics Announces the Release of the Rapidlab 1200 Series Version 2.0 Software
6. AWT, Inc. Continues Rapid Expansion in Middle East
7. GenPrime Initiates External Clinical Trials of its Bacterial Contamination Test for Rapid Detection of Bacteria in Platelets
8. Rapid Pathogen Screening Announces New Vice President of Corporate Relations
9. Varian Medical Systems to Introduce RapidArc(TM) Radiotherapy Technology for Volumetric Arc Therapy at ASTRO 2007
10. Varian Medical Systems to Unveil RapidArc(TM) Volumetric Arc Therapy and Other Products Designed to Speed Delivery of Precision Radiotherapy and Brachytherapy
11. HearAtLast Continues Rapid Expansion, Opening Two New Retail Locations in Richmond Hill and Markham Wal-Mart Stores Number 3195 and 3053
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Brooklyn, NY (PRWEB) , ... June 27, 2016 ... ... is using cutting edge technology to revolutionize the emergency ambulance transport experience for ... Many are aware of how Uber has disrupted the taxi industry through the ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at www.diabetesscholars.org by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
Breaking Medicine Technology: