Navigation Links
Mushroom compound appears to improve effectiveness of cancer drugs
Date:10/11/2011

AUGUSTA, Ga. A compound isolated from a wild, poisonous mushroom growing in a Southwest China forest appears to help a cancer killing drug fulfill its promise, researchers report.

The compound, verticillin A, sensitizes cancer cells to TRAIL, a drug which induces cancer cells to self destruct, said Dr. Kebin Liu, cancer immunologist at the Georgia Health Sciences University Cancer Center and corresponding author of the study in the journal Cancer Research.

The compound appears to keep cancer cells from developing resistance to TRAIL, short for tumor necrosis factor-related apoptosis inducing ligand. Drug resistance, intrinsic or acquired, is a major problem for cancer patients, accounting for greater than 90 percent of treatment failures in patients with metastatic disease.

"If we can make drugs work again, more people will survive," Liu said.

Patient experience has shown cancer's skill at desensitizing itself to the TRAIL. "It looks as though most cancer cells have found a way to become resistant and evade its action," said Dr. Wendy Bollag, cell physiologist at GHSU and a study co-author. Tenacious cancer cells also are naturally resistant to cell suicide, which is how TRAIL works.

In mice, they found verticillin A alone was adequate to kill cancer cells, but the required dose made the mice sick, a common problem with many cancer therapies. However, when a lower dose was paired with TRAIL, it became a powerful, more tolerable recipe that killed previously resistant cells.

They also found that the compound improved the efficacy of commonly used cancer drugs etoposide and cisplatin, which also work by promoting cancer cell death but are less targeted than TRAIL. "We believe this could be a good companion drug for a lot of cancer therapies," Liu said.

One way verticillin A appears to work is by upregulating BN1P3, a gene that promotes cell death, the researchers said. Cancer cells work to silence BN1P3 through a process called DNA methylation; verticillin A appears to modify the same process to turn the gene on.

All cells use DNA methylation but cancer cells use it differently, said Dr. Keith Robertson, cancer epigeneticist and Georgia Cancer Coalition Scholar. "Verticillin A may be working by altering methylation in a way that makes the cancer cells sensitive to TRAIL," Robertson said.

Their studies were of metastatic human colon cancer cells, which are highly resistant to treatment, including TRAIL, both in culture as well as transplanted into mice. They did similar studies on sarcoma, lung adenocarcinoma and breast cancer.

Additional toxicity studies are needed before moving forward with clinical trials, Bollag said. The researchers also want to pursue the compound's potential in melanoma and pancreatic cancer.

Verticillin A was isolated from mushrooms in Dr. Ping Wu's laboratory at the Research Centre of Siyuan Natural Pharmacy and Biotoxicology at China's Zhejiang University and brought to GHSU by former postdoctoral fellow, Dr. Feiyan Liu, the study's first author, who studied with Kebin Liu in Augusta for two years. The Chinese university is involved in extensive studies to isolate active compounds from plants to explore their therapeutic potential and both Dr. Lius liked verticillin A's aggressive response against cancer.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Magic Mushroom Compound Triggered Positive Personality Change in Study
2. Magic Mushroom Hallucinogen Might Help Cancer Patients
3. Researchers study benefits of white button mushrooms
4. NYU researchers develop compound to block signaling of cancer-causing protein
5. Researchers evaluate red wine compound for treating concussions in pro boxers
6. Mechanism behind compounds effects on skin inflammation and cancer progression
7. Curcumin compound improves effectiveness of head and neck cancer treatment, U-M study finds
8. Tobacco-derived compound prevents memory loss in Alzheimers disease mice
9. UGA compound offers new hope for treatment of painful adult shingles
10. Scientists develop compound that effectively halts progression of multiple sclerosis
11. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mushroom compound appears to improve effectiveness of cancer drugs
(Date:7/26/2017)... ... ... Six greater Bay Area roller derby leagues are partnering with Brown Paper Tickets and the ... of blood drives in California, beginning July 29. Make ‘Em Bleed roller derby blood drives ... to have helped to save up to 2700 lives. , “The Make ‘Em Bleed blood ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... (ISPE) will host its 2017 Process Validation and Process Validation Statistics ... comprehensive solutions to process validation lifecycle challenges faced by process validation professionals ...
(Date:7/26/2017)... ... July 26, 2017 , ... A global ... in Jupiter. The state of the art center will provide advanced surgical ... a goal of providing heart patients longer lives. , North American Veterinary Heart ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... innovative specialty pharmacies, has released an updated version of the HCV Treatment Path ... for treating chronic hepatitis C virus (HCV) infection. All of the latest HCV ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... to announce the launch of their partnership to provide the Pharmacist eCare ... first pharmacy-focused platform in the country with the ability to develop the Pharmacist ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017 ... the University of Alberta in Edmonton, ... Nature,s partner journal, Schizophrenia 1 , demonstrating that ... of schizophrenia with 74% accuracy. This retrospective analysis ... specific symptoms in schizophrenia patients with significant correlation, ...
(Date:7/20/2017)... PAUL, Minn. , July 20, 2017  Prime Therapeutics ... Jonathan Gavras , M.D., following today,s Institute for Clinical ... report on the effectiveness and value of abuse-deterrent ... manager on the policy roundtable at the meeting. ... is not a material cost benefit to the use of ...
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
Breaking Medicine Technology: