Navigation Links
Muscling in on type 2 diabetes
Date:2/26/2009

Research by kinesiology investigator Dustin Hittel, PhD, has proven that muscle in extremely obese individuals produces large amounts of a protein called myostatin, which normally inhibits muscle growthsuggesting that for Type 2 diabetics, and the very obese, the task of getting healthy may be more difficult than initially thought.

It has been known for some years that naturally occurring mutations in the gene which controls myostatin results in doublemuscling in cattle, dogs and even humans. Many in the body building community believe that blocking myostatin is a shortcut to the Arnold Schwarzenegger body.

The flipside is that producing too much myostatin has been linked with muscle wasting conditions such as HIV-AIDS, starvation and now, Type 2 diabetes.

Hittel believes this may be due to a pre-diabetic condition known as insulin resistance that "tricks" the muscles into thinking the body is starving despite the fact that blood sugar levels are skyrocketing.

"When that happens, the body reverses muscle production using myostatin," says Hittel. "This is particularly worrisome because losing muscle mass further erodes your ability to control your blood sugar with exercise."

One of the tell-tale signs of the transition between insulin resistance and full-blown Type 2 diabetes is a loss of muscle mass.

"Losing muscle mass makes sense from an evolutionary perspective since having large muscles during famine puts you at a serious risk for starvation," explains Hittel. "Unfortunately, this survival mechanism has left us ill-equipped to deal with a Western lifestylelots of calories, little exerciseand it has laid the groundwork for the current epidemic of Type 2 diabetes."

"The goal of my research is to understand how obesity, diet and exercise influence our metabolism and interact with our genome. This research sheds some light on an important part of the puzzle."


'/>"/>

Contact: Don McSwiney
don.mcswiney@ucalgary.ca
403-220-7652
University of Calgary
Source:Eurekalert

Page: 1

Related medicine news :

1. Jonas Brothers Change for the Children Foundation to Provide Diabetes Camp Scholarships
2. Diabetes a risk factor for postpartum depression
3. Diabetes Linked to Depression During and After Pregnancy
4. Pennsylvanians May Donate Part of Tax Refund to Support Juvenile Diabetes Research
5. Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes
6. One in Five Augustans With Type 2 Diabetes Mistakenly Believe That Being Obese or Overweight Can Positively Impact Their Disease
7. LSUHSC research may benefit diabetes by increasing understanding of how to control islet cell growth
8. Novo Nordisk Appoints Andy Ajello as Vice President for National Diabetes Sales, Managed Care and Government Accounts
9. GSK Initiates Phase III Programme for Novel Type 2 Diabetes Medication, Syncria(R) (albiglutide)
10. Cardiovascular Disease and Diabetes: New Blog and Slide Presentation on the Diabetes Best Practices Website Discuss the Most Recent Studies in this Field
11. PDHI Adds Diabetes and Heart Disease Prevention to ConXus Steps Library of Action Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... ... Carnival Vista – the line’s largest cruise ship ever. To help guests ... an infographic spotlighting the Carnival Vista ’s most exciting features and ...
(Date:5/2/2016)... ... ... It has just been announced Jack Uldrich, renowned futurist and ... of May. , Uldrich is the author of 11 books and a regular guest ... the Science Channel’s FutureScape and Discovery Channel’s Inside Out. , Known the world over ...
(Date:5/2/2016)... Dallas, Texas (PRWEB) , ... May 02, 2016 ... ... Volume 3, Issue 1 of Patient Experience Journal (PXJ), an international, open ... patient experience. With almost half the issue representing international (non-US) based authors, the ...
(Date:5/2/2016)... ... 02, 2016 , ... Beanfields, PBC, makers of Beanfields Bean ... students at University of Colorado in Boulder to create new advertising campaigns. , ... the School of Journalism, who selected Beanfields as the brand on which to ...
(Date:5/2/2016)... ... May 02, 2016 , ... Amica Life Insurance ... understand life insurance throughout various life stages. , The site launched on April ... calculator and content specific to the times when life insurance matters most. , ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... Jersey , April 29, 2016 ... Suite for Life Sciences, Product Development Capabilities in ... Life Science Customer Base . ... provider, today announced the acquisition of Skura Corporation,s ... global leader in adaptive sales enablement technology for ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... April 28, 2016 Treato ... on healthcare, announced today that it has been named ... Cool Vendor in Life Sciences, 2016, Stephen ...  The report focuses on life-science- oriented analytics, algorithms and ... patients and doctors, confirm medication ingestion, and analyze unstructured ...
Breaking Medicine Technology: