Navigation Links
Muscle deterioration in patients with lung disease seen connected to CO2

Jerusalem, April 22, 2009 -- Muscle deterioration in patients with lung diseases might be a direct consequence of high carbon dioxide levels in their blood, an international team of researchers headed by Prof. Yosef Gruenbaum of the Hebrew University of Jerusalem has found.

The incidence of lung diseases continues to increase in the world's populations. For example, one in seven persons in the UK is affected by some form of chronic lung disease, most commonly chronic obstructive pulmonary disease (COPD) and asthma.

Many of these diseases also cause, in the worst cases, muscle deterioration as well as elevated levels of carbon dioxide (hypercapnia) in the bloodstream. In a normal situation, the lungs allow for a proper balance of oxygen from the atmosphere reaching the bloodstream and carbon dioxide from the bloodstream being transferred to the atmosphere.

It is still a matter of some controversy whether the high carbon dioxide levels in patients with chronic lung disease actually cause damage to those patients and specifically whether the loss of muscle is a consequence of those heightened levels.

Prof. Gruenbaum and his Ph.D. student Kfir Sharabi from the Department of Genetics at The Hebrew University, in collaboration with the groups of Dr. Amos J. Simon and Dr. Gideon Rechavi from the Sheba Medical Center and Tel Aviv University, and Dr. Jacob I. Sznajder, Dr. Richard I. Morimoto and Dr. Greg J. Beitel from Northwestern University in the U.S., teamed together to answer these questions. The results of their research appeared in a recent study published in the Proceedings of the National Academy of Sciences (PNAS) in the US.

They used the worm C. elegans, in which many basic processes are discovered, to study its response to induced elevated carbon dioxide levels. They found that levels exceeding 9% (normal level in living beings is around 5%) reduced the worm's spontaneous movement capability, which was accompanied by deterioration of body muscle.

(These results suggest re-evaluating the consequences of the procedure of permissive hypercapnia, also known as therapeutic hypercapnia, in which patients with acute lung injury are treated with increased levels of carbon dioxide.)

In addition, there were signs that the experimental animals showed slower development, were less fertile, but, surprisingly, had an increased lifespan. Another unexpected result was the large number of genes that showed specific and dynamic changes after only one hour of exposure to the heightened carbon dioxide levels.

The researchers noted also that physiological and molecular response to hypercapnia appeared to be different from responses to heat shock or to low oxygen levels.


Contact: Jerry Barach
The Hebrew University of Jerusalem

Related medicine news :

1. The Pill May Limit Muscle Gains in Women
2. Three Medical Centers Awarded Funds to Study Generation of Cardiac Muscle Cells
3. Muscle Mass Wont Grow in Women Over 80
4. Max Muscle Sports Nutrition Franchising Draws Record Interest
5. Innovative Sports Supplement Firm Muscles Up to General Nutrition Centers in a New National Partnership
6. Muscle Pharm Signs UFC Athlete Shane Carwin
7. Skin Cells Turned Into Working Heart Muscle
8. Growth hormone treatment after weight loss surgery prevents loss of muscle mass
9. Vitamin D tied to muscle power in adolescent girls
10. Quadra Cuts the Official Weight Loss Product of Max Muscle Sports Nutrition $25,000 MaxFormation Life Challenge
11. Unique skeletal muscle design contributes to spine stability
Post Your Comments:
Related Image:
Muscle deterioration in patients with lung disease seen connected to CO2
(Date:11/24/2015)... ... ... Charitable giving is at its peak during the holidays. In fact, ... the year totalling over $358 billion in 2014. With more than 1.5 million ... individuals who want to “give back” during the holidays. , “With so many charities ...
(Date:11/24/2015)... ... November 24, 2015 , ... The hospitals ... to several aspects of orthopedic care. They have received recognition for excellence from ... orthopedic care. , Becker's Hospital Review selected hospitals for inclusion based on ...
(Date:11/24/2015)... Port Richey, FL (PRWEB) , ... November 24, 2015 , ... ... it deems a growing epidemic as deaths from prescription opioids in the United States ... heroin and cocaine. In 2013 alone, opioids were involved in 37 percent of all ...
(Date:11/24/2015)... ... November 24, 2015 , ... Serenity Point Rehabilitation, a holistic treatment center for ... with some of the staff members at their recovery center. The videos highlight some ... as some of the things that make their recovery program so unique. , “Making ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... award at Cleveland University-Kansas City (CU-KC), in Overland Park, Kansas. Benson, ... Chiropractor and University President Carl S. Cleveland III on October 16. , “Katie ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... BOULDER, Colo. , Nov. 24, 2015 /PRNewswire/ ... announced that its Chief Executive Officer, Ron ... Annual Healthcare Conference in New York.  The public ... a webcast on the Array BioPharma website.Event:Piper Jaffray ... OfficerDate:  , Wednesday, December 2, 2015Time:1:30 p.m. Eastern ...
(Date:11/24/2015)... Nueva York , 24 de noviembre de ... del Avery Breathing Pacemaker System, se complace anunciar ... Ph.D. como consultor clínico. ... Foto -   ... Jonzon es un fisiólogo y consultor en neonatología ...
(Date:11/24/2015)... --> --> ... by Product Type (Bone Graft, Bine Graft Substitute, Platelet Rich ... Lumbar Interbody Fusion), End User, and Geography - Global Forecast ... at $1.90 Billion in 2014 and is expected to reach ... the forecast period of 2015 to 2020. Browse ...
Breaking Medicine Technology: