Navigation Links
Muscle deterioration in patients with lung disease seen connected to CO2

Jerusalem, April 22, 2009 -- Muscle deterioration in patients with lung diseases might be a direct consequence of high carbon dioxide levels in their blood, an international team of researchers headed by Prof. Yosef Gruenbaum of the Hebrew University of Jerusalem has found.

The incidence of lung diseases continues to increase in the world's populations. For example, one in seven persons in the UK is affected by some form of chronic lung disease, most commonly chronic obstructive pulmonary disease (COPD) and asthma.

Many of these diseases also cause, in the worst cases, muscle deterioration as well as elevated levels of carbon dioxide (hypercapnia) in the bloodstream. In a normal situation, the lungs allow for a proper balance of oxygen from the atmosphere reaching the bloodstream and carbon dioxide from the bloodstream being transferred to the atmosphere.

It is still a matter of some controversy whether the high carbon dioxide levels in patients with chronic lung disease actually cause damage to those patients and specifically whether the loss of muscle is a consequence of those heightened levels.

Prof. Gruenbaum and his Ph.D. student Kfir Sharabi from the Department of Genetics at The Hebrew University, in collaboration with the groups of Dr. Amos J. Simon and Dr. Gideon Rechavi from the Sheba Medical Center and Tel Aviv University, and Dr. Jacob I. Sznajder, Dr. Richard I. Morimoto and Dr. Greg J. Beitel from Northwestern University in the U.S., teamed together to answer these questions. The results of their research appeared in a recent study published in the Proceedings of the National Academy of Sciences (PNAS) in the US.

They used the worm C. elegans, in which many basic processes are discovered, to study its response to induced elevated carbon dioxide levels. They found that levels exceeding 9% (normal level in living beings is around 5%) reduced the worm's spontaneous movement capability, which was accompanied by deterioration of body muscle.

(These results suggest re-evaluating the consequences of the procedure of permissive hypercapnia, also known as therapeutic hypercapnia, in which patients with acute lung injury are treated with increased levels of carbon dioxide.)

In addition, there were signs that the experimental animals showed slower development, were less fertile, but, surprisingly, had an increased lifespan. Another unexpected result was the large number of genes that showed specific and dynamic changes after only one hour of exposure to the heightened carbon dioxide levels.

The researchers noted also that physiological and molecular response to hypercapnia appeared to be different from responses to heat shock or to low oxygen levels.


Contact: Jerry Barach
The Hebrew University of Jerusalem

Related medicine news :

1. The Pill May Limit Muscle Gains in Women
2. Three Medical Centers Awarded Funds to Study Generation of Cardiac Muscle Cells
3. Muscle Mass Wont Grow in Women Over 80
4. Max Muscle Sports Nutrition Franchising Draws Record Interest
5. Innovative Sports Supplement Firm Muscles Up to General Nutrition Centers in a New National Partnership
6. Muscle Pharm Signs UFC Athlete Shane Carwin
7. Skin Cells Turned Into Working Heart Muscle
8. Growth hormone treatment after weight loss surgery prevents loss of muscle mass
9. Vitamin D tied to muscle power in adolescent girls
10. Quadra Cuts the Official Weight Loss Product of Max Muscle Sports Nutrition $25,000 MaxFormation Life Challenge
11. Unique skeletal muscle design contributes to spine stability
Post Your Comments:
Related Image:
Muscle deterioration in patients with lung disease seen connected to CO2
(Date:10/13/2015)... ... October 13, 2015 , ... Altec Products, ... sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits to take place ... NAVUG Summit are independent user conferences designed and led by users to provide ...
(Date:10/13/2015)... ... October 13, 2015 , ... Element Blue ™, a ... new company, RightSensor™ LLC, an Internet of Things (IoT) hardware supplier that delivers ... fully-managed approach for customers requiring sensor hardware for critical data environments. , RightSensor™, ...
(Date:10/13/2015)... ... 13, 2015 , ... Relay (, a technology company that ... significant contract that will provide its award-winning private messaging solution to Independence Blue ... success of its Relay program, IBX Wire™, which now has over 550,000 members ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading embedded ... See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a USB 3.0 interface ... e-con’s See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch OV4682 ...
(Date:10/13/2015)... Tenn. (PRWEB) , ... October 13, 2015 , ... A ... and that’s why SmileCareClub , the leading remote invisible aligner system, has joined ... who would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  EndoChoice Holdings, Inc. (NYSE:  GI) announced today that ... on Thursday, November 5, 2015 before the market open. ... . --> EndoChoice will hold ... 9:00 a.m. ET to discuss the results. The dial-in ... 317-5469 for international callers. A live webcast of the ...
(Date:10/13/2015)... Regen BioPharma, Inc. , ... Harry Lander , PhD as its new president.  Dr. Lander ... David Koos as Regen BioPharma prepares to take the ... --> Regen BioPharma, Inc. , (OTCBB: RGBP, ... , PhD as its new president.  Dr. Lander will work ...
(Date:10/13/2015)... 13, 2015 China Jo-Jo Drugstores, ... Jo-Jo "), a leading China-based retail, wholesale and online ... own online and retail pharmacies, announced preliminary half year ... online pharmacy through , growing 438% year ... 25%. China Jo-Jo,s online sales ...
Breaking Medicine Technology: