Navigation Links
Muscle Mass May Not Explain High Creatinine in Black Kidney Patients
Date:4/18/2008

Findings challenge belief that racial disparities were result of age, body composition

FRIDAY, April 18 (HealthDay News) -- Differences in muscle mass related to younger age or body composition may not explain why black patients with advanced kidney disease have higher levels of creatinine than white patients, says a U.S. study that challenges a widely held belief.

Creatinine is a standard indicator of kidney function. A higher level of creatinine is generally a sign of lower kidney function.

In this study, researchers at the University of California, San Francisco School of Medicine examined serum creatinine concentrations and body composition in more than 3,000 kidney dialysis patients. As expected, blacks had higher creatinine levels than non-black patients.

"A widely assumed explanation for this racial difference is that black patients tend to develop end-stage kidney disease earlier than whites. So blacks on dialysis tend to be younger than whites and persons of other races and ethnicities and so may have more muscle mass, and creatinine is a natural breakdown product of muscle," study leader Dr. Joy Hsu said in a prepared statement.

To test this theory, Hsu and colleagues used something called bioelectrical impedance analysis to estimate the patient's muscle mass.

"We hypothesized that adjusting for muscle mass and related factors would eliminate or reduce the racial differences in serum creatinine levels," Hsu said.

However, even after making that adjustment, black patients had significantly higher creatinine levels.

"The higher creatinine levels in black patients compared to non-black patients could not be entirely explained by differences in age, sex, body size, or muscle mass," Hsu said.

The study was published online in the Clinical Journal of the American Society of Nephrology and is expected to be published in the July print edition of the journal.

More research is needed to uncover why black patients with kidney disease have higher creatinine levels than other patients. The "answer or answers to this question may help explain why blacks are affected by progressive chronic kidney disease more so than whites," Hsu said.

More information

The U.S. National Kidney Disease Education Program has more about kidney disease.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. New treatment boosts muscle function in myasthenia gravis
3. New Drug Aids Muscle Function in Myasthenia Gravis
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Muscle patterns in women may be linked to at risk positioning for ACL tears
6. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
7. Study reveals how stem cells decide to become either skeletal or smooth muscle
8. Pre-Workout Stretching Wont Prevent Sore Muscles
9. Steroids Are Abused for Skin, Not Just Muscles
10. AUA releases new guidelines on non-muscle invasive bladder cancer
11. Scientists identify gene responsible for statin-induced muscle pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: