Navigation Links
Muscle Mass May Not Explain High Creatinine in Black Kidney Patients
Date:4/18/2008

Findings challenge belief that racial disparities were result of age, body composition

FRIDAY, April 18 (HealthDay News) -- Differences in muscle mass related to younger age or body composition may not explain why black patients with advanced kidney disease have higher levels of creatinine than white patients, says a U.S. study that challenges a widely held belief.

Creatinine is a standard indicator of kidney function. A higher level of creatinine is generally a sign of lower kidney function.

In this study, researchers at the University of California, San Francisco School of Medicine examined serum creatinine concentrations and body composition in more than 3,000 kidney dialysis patients. As expected, blacks had higher creatinine levels than non-black patients.

"A widely assumed explanation for this racial difference is that black patients tend to develop end-stage kidney disease earlier than whites. So blacks on dialysis tend to be younger than whites and persons of other races and ethnicities and so may have more muscle mass, and creatinine is a natural breakdown product of muscle," study leader Dr. Joy Hsu said in a prepared statement.

To test this theory, Hsu and colleagues used something called bioelectrical impedance analysis to estimate the patient's muscle mass.

"We hypothesized that adjusting for muscle mass and related factors would eliminate or reduce the racial differences in serum creatinine levels," Hsu said.

However, even after making that adjustment, black patients had significantly higher creatinine levels.

"The higher creatinine levels in black patients compared to non-black patients could not be entirely explained by differences in age, sex, body size, or muscle mass," Hsu said.

The study was published online in the Clinical Journal of the American Society of Nephrology and is expected to be published in the July print edition of the journal.

More research is needed to uncover why black patients with kidney disease have higher creatinine levels than other patients. The "answer or answers to this question may help explain why blacks are affected by progressive chronic kidney disease more so than whites," Hsu said.

More information

The U.S. National Kidney Disease Education Program has more about kidney disease.



-- Robert Preidt



SOURCE: American Society of Nephrology, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. New treatment boosts muscle function in myasthenia gravis
3. New Drug Aids Muscle Function in Myasthenia Gravis
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Muscle patterns in women may be linked to at risk positioning for ACL tears
6. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
7. Study reveals how stem cells decide to become either skeletal or smooth muscle
8. Pre-Workout Stretching Wont Prevent Sore Muscles
9. Steroids Are Abused for Skin, Not Just Muscles
10. AUA releases new guidelines on non-muscle invasive bladder cancer
11. Scientists identify gene responsible for statin-induced muscle pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
Breaking Medicine Technology: