Navigation Links
Muscle Mass May Not Explain High Creatinine in Black Kidney Patients

Findings challenge belief that racial disparities were result of age, body composition

FRIDAY, April 18 (HealthDay News) -- Differences in muscle mass related to younger age or body composition may not explain why black patients with advanced kidney disease have higher levels of creatinine than white patients, says a U.S. study that challenges a widely held belief.

Creatinine is a standard indicator of kidney function. A higher level of creatinine is generally a sign of lower kidney function.

In this study, researchers at the University of California, San Francisco School of Medicine examined serum creatinine concentrations and body composition in more than 3,000 kidney dialysis patients. As expected, blacks had higher creatinine levels than non-black patients.

"A widely assumed explanation for this racial difference is that black patients tend to develop end-stage kidney disease earlier than whites. So blacks on dialysis tend to be younger than whites and persons of other races and ethnicities and so may have more muscle mass, and creatinine is a natural breakdown product of muscle," study leader Dr. Joy Hsu said in a prepared statement.

To test this theory, Hsu and colleagues used something called bioelectrical impedance analysis to estimate the patient's muscle mass.

"We hypothesized that adjusting for muscle mass and related factors would eliminate or reduce the racial differences in serum creatinine levels," Hsu said.

However, even after making that adjustment, black patients had significantly higher creatinine levels.

"The higher creatinine levels in black patients compared to non-black patients could not be entirely explained by differences in age, sex, body size, or muscle mass," Hsu said.

The study was published online in the Clinical Journal of the American Society of Nephrology and is expected to be published in the July print edition of the journal.

More research is needed to uncover why black patients with kidney disease have higher creatinine levels than other patients. The "answer or answers to this question may help explain why blacks are affected by progressive chronic kidney disease more so than whites," Hsu said.

More information

The U.S. National Kidney Disease Education Program has more about kidney disease.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, April 16, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. New treatment boosts muscle function in myasthenia gravis
3. New Drug Aids Muscle Function in Myasthenia Gravis
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Muscle patterns in women may be linked to at risk positioning for ACL tears
6. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
7. Study reveals how stem cells decide to become either skeletal or smooth muscle
8. Pre-Workout Stretching Wont Prevent Sore Muscles
9. Steroids Are Abused for Skin, Not Just Muscles
10. AUA releases new guidelines on non-muscle invasive bladder cancer
11. Scientists identify gene responsible for statin-induced muscle pain
Post Your Comments:
(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... AMSTERDAM , Sept. 25, 2017   ... Trial Master File solutions, today—from the IQPC Trial ... Amsterdam , NL)—announced that EastHORN Clinical Services ... its clinical programs and TMF management. EastHORN, a ... Montrium,s eTMF platform to increase transparency to enable ...
(Date:9/19/2017)... Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses ... today:   ... Jim ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and business ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: