Navigation Links
Muscle Fatigue Drug May Fight Heart Failure

It seems to plug calcium leaks that cause tiring in muscles, study says

TUESDAY, Feb. 12 (HealthDay News) -- An experimental drug may help fatigued athletes and patients weakened by heart failure regain their energy, say physiologists at Columbia University Medical Center.

Tests on mice and humans found that, after extreme exercise regimens, tiny leaks of calcium continuously enter the muscle cells, according to the study published online in the Feb. 11 issue of the Proceedings of the National Academy of Sciences. The leak weakens the force produced by the muscle and also turns on a protein-digesting enzyme that damages the muscle fibers, leading to the overall feeling of exhaustion for days or weeks afterward.

This same leak was previously discovered by Columbia researchers in the muscles of animals with heart failure.

The researchers then developed an experimental drug to plug these leaks, and tested it on mice subjected to daily three-hour swims over three weeks. Without the drugs, mice were exhausted. With the drug, the mice were still energetic, had lost less exercise capacity after three weeks, and their muscles showed fewer signs of calcium leakage, atrophy and less muscle damage.

While extreme athletes, such as marathoners, often regain their strength and vigor after several days, the findings suggest the drug may provide relief from the severe exhaustion that prevents patients with chronic heart failure from performing simple tasks.

"People with chronic heart failure are subject to this same kind of muscle leak and damage constantly, even without doing any exercise," study senior author Dr. Andrew Marks, chairman of Columbia's department of physiology and cellular biophysics, said in a prepared statement. "One of these patients' most debilitating symptoms is muscle weakness and fatigue, which can be so bad they can't get out of bed, brush their teeth or feed themselves."

Plans are under way to test the drug at other medical centers in patients with heart failure to see if it relieves fatigue and improves heart function. Even if successful, it will take several years before the drug will be commercially available.

Fatigue experienced by heart failure patients does not stem from reduced blood and oxygen being supplied to the muscles by the heart, as one might expect. Instead, Marks' previous research in muscles of mice with heart failure suggested the cause is calcium leak in muscle cells, which reduce the ability of a single muscle to contract repeatedly before losing force.

"We then had a hunch that the process that produces fatigue in heart failure patients also may be responsible for the fatigue felt by athletes after a marathon or extreme training," study first author Andrew Bellinger said in a prepared statement. "Our new paper shows that fatigue in both patients and athletes probably stems from the same leak."

More information

The U.S. Centers for Disease Control and Prevention has more facts about heart failure.

-- Kevin McKeever

SOURCE: Columbia University Medical Center, news release, Feb. 11, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. New treatment boosts muscle function in myasthenia gravis
3. New Drug Aids Muscle Function in Myasthenia Gravis
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Muscle patterns in women may be linked to at risk positioning for ACL tears
6. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
7. Study reveals how stem cells decide to become either skeletal or smooth muscle
8. Pre-Workout Stretching Wont Prevent Sore Muscles
9. Steroids Are Abused for Skin, Not Just Muscles
10. AUA releases new guidelines on non-muscle invasive bladder cancer
11. Scientists identify gene responsible for statin-induced muscle pain
Post Your Comments:
Related Image:
Muscle Fatigue Drug May Fight Heart Failure
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
(Date:6/24/2016)... ... 24, 2016 , ... National recruitment firm Slone Partners is pleased ... and genomics experience, as Vice President of North American Capital Sales at HTG ... leading the sales team in the commercialization of the HTG EdgeSeq system and associated ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: