Navigation Links
Muscle Fatigue Drug May Fight Heart Failure
Date:2/12/2008

It seems to plug calcium leaks that cause tiring in muscles, study says

TUESDAY, Feb. 12 (HealthDay News) -- An experimental drug may help fatigued athletes and patients weakened by heart failure regain their energy, say physiologists at Columbia University Medical Center.

Tests on mice and humans found that, after extreme exercise regimens, tiny leaks of calcium continuously enter the muscle cells, according to the study published online in the Feb. 11 issue of the Proceedings of the National Academy of Sciences. The leak weakens the force produced by the muscle and also turns on a protein-digesting enzyme that damages the muscle fibers, leading to the overall feeling of exhaustion for days or weeks afterward.

This same leak was previously discovered by Columbia researchers in the muscles of animals with heart failure.

The researchers then developed an experimental drug to plug these leaks, and tested it on mice subjected to daily three-hour swims over three weeks. Without the drugs, mice were exhausted. With the drug, the mice were still energetic, had lost less exercise capacity after three weeks, and their muscles showed fewer signs of calcium leakage, atrophy and less muscle damage.

While extreme athletes, such as marathoners, often regain their strength and vigor after several days, the findings suggest the drug may provide relief from the severe exhaustion that prevents patients with chronic heart failure from performing simple tasks.

"People with chronic heart failure are subject to this same kind of muscle leak and damage constantly, even without doing any exercise," study senior author Dr. Andrew Marks, chairman of Columbia's department of physiology and cellular biophysics, said in a prepared statement. "One of these patients' most debilitating symptoms is muscle weakness and fatigue, which can be so bad they can't get out of bed, brush their teeth or feed themselves."


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. New treatment boosts muscle function in myasthenia gravis
3. New Drug Aids Muscle Function in Myasthenia Gravis
4. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
5. Muscle patterns in women may be linked to at risk positioning for ACL tears
6. Endoscopic resection is a safe and effective treatment for gastrointestinal smooth muscle tumors
7. Study reveals how stem cells decide to become either skeletal or smooth muscle
8. Pre-Workout Stretching Wont Prevent Sore Muscles
9. Steroids Are Abused for Skin, Not Just Muscles
10. AUA releases new guidelines on non-muscle invasive bladder cancer
11. Scientists identify gene responsible for statin-induced muscle pain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Muscle Fatigue Drug May Fight Heart Failure
(Date:8/23/2014)... Boston, MA (PRWEB) August 23, 2014 ... now have a study aid in preparing for Food ... safety practice test by Dynamic Path. , Dynamic ... study module, which includes more than 200 review questions ... study materials are designed to cover requirements of the ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/22/2014)... (PRWEB) August 23, 2014 Search ... on the first page of search engines and ... SEO Hosting has recently compared many Linux hosting ... and Bluehost are the most recommended Linux hosting ... Australia and Europe to buy high quality Linux ...
(Date:8/22/2014)... Skmen.com, an experienced supplier of fashionable clothes, has unveiled ... online store. Moreover, all these excellent items are available ... the international clients can obtain these cheap bohemian ... company’s professional online workers update its product line every ... latest information about its new arrivals and the current ...
(Date:8/22/2014)... August 22, 2014 MyWriters.com , ... written by marketing experts for marketers to help them ... caught the attention of Shane Michaels, prompting an investigative ... marketing in any way knows that content is king ... industry,” reports Michaels. “But even though content is extremely ...
Breaking Medicine News(10 mins):Health News:Food Handler Safety Certification Made Easy with Dynamic Path 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2
... 2 As health care organizations,continue to wrestle with ... finding inspiration from the skies - the aviation,industry., ... aviation,industry techniques in health care was the focus of ... by The Risk Management and,Patient Safety Institute (RM&PSI)., ...
... Clinic (ADC) - San,Diego announces Dr. Brett Wildermuth ... Veterinary Dermatology (ACVD)., Dr. Brett Wildermuth received ... of California, Davis in 2001. Upon graduation he,completed ... Hospital,and Referral Center in San Diego, working with ...
... NEW YORK, June 2, 2008 The problem of ... a container has challenged mathematicians for centuries. A ... York (CCNY) has come up with a solution that ... to shipping fruit. , Writing in the May 29 ...
... The Blue Cross and Blue Shield,Association (BCBSA) has ... Bariatric Care for 2008., According to the Agency ... bariatric surgeries increased 400 percent from 1998 to,2004. Obesity ... so bariatric surgery is being considered as a means ...
... The Walk on the Capitol,is proud to announce ... as special guest speaker for our National obesity awareness ... on the Capitol is a,history-making awareness event that will ... attention to the obesity epidemic and,the need for expanded ...
... and satellite ... symposium, ... DSCI), a provider of advanced wound care products,announced today that eleven ... & Burn Dressings with Active,Leptospermum Honey will be presented at the ...
Cached Medicine News:Health News:Health Care Leaders Gather to Gain New Safety, Risk Management Insights From Aviation Industry Experts 2Health News:Health Care Leaders Gather to Gain New Safety, Risk Management Insights From Aviation Industry Experts 3Health News:Animal Dermatology Clinic - San Diego Announces Dr. Brett Wildermuth, DVM, Achieves Diplomate Status With the American College of Veterinary Dermatology 2Health News:Highmark Blue Shield and the Blue Cross Blue Shield Association Name Area Hospitals as 2008 Blue Distinction Centers for Bariatric Care 2Health News:Television Star Caitlin Van Zandt Signs-on as Special Guest Speaker for National Obesity Awareness Event in Washington, DC, on June 17 2Health News:Derma Sciences Announces Numerous Clinical Presentations on MEDIHONEY(TM) Wound & Burn Dressings at Upcoming WUWHS Conference 2Health News:Derma Sciences Announces Numerous Clinical Presentations on MEDIHONEY(TM) Wound & Burn Dressings at Upcoming WUWHS Conference 3Health News:Derma Sciences Announces Numerous Clinical Presentations on MEDIHONEY(TM) Wound & Burn Dressings at Upcoming WUWHS Conference 4
(Date:8/22/2014)... Research and Markets has announced the addition ... Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... a focus on the Chinese situation. The report ... classifications, applications and industry chain structure. The particulate respirators ...
(Date:8/22/2014)... , August 22, 2014 ... TVs Today Lincor announced general availability of ... solution that delivers a range of education, entertainment and ...      (Logo: http://photos.prnewswire.com/prnh/20140822/702945) , " ... point of care patient engagement to bedside smart devices, ...
(Date:8/22/2014)... , Aug. 22, 2014 /PRNewswire/ - SQI ... that develops and commercializes proprietary technologies and products ... has entered into a Master Service Agreement to ... DNA-based pathogen detection assays. During the initial phase ... deliver an automated working prototype of one of ...
Breaking Medicine Technology:Global and Chinese Particulate Respirators Industry Report 2014 2Lincor Unveils Next Generation TV-based Patient Engagement Solution 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 2SQI Diagnostics Contracted to Automate Pathogen Detection Assays 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: