Navigation Links
Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90
Date:8/23/2010

The protein Hsp90 plays a significant role in the survival of cells that are exposed to stress. Researchers at the Technische Universitaet Muenchen (TUM) uncovered this protein's mode of operation some time ago but now Hsp90 has surprised even the experts with an unexpected pattern of motion. The results are published in the current online issue of the renowned science journal PNAS and may help researchers discover specific cancer medication.

Proteins are the motors of the cell: They transport, among other things, nutrients, move our muscles, convert substances chemically or fold other proteins. The so-called heat shock protein Hsp90 is eminently important for our cells since it plays a decisive role in many basic processes in humans as well as in bacteria or yeasts. For example, it is decisive in folding polypeptide chains into functioning proteins with very precisely defined spatial structures. Especially when cells are exposed to stress through heat or poisonous substances, Hsp90 production increases to keep the damage in check.

The anti-stress protein is a dimer (which consists of two identical proteins) and can be roughly divided into three segments: the N terminal domain at the top, the middle domain and the C terminal at the bottom. Hsp90 taps the energy it requires for its work from the slow splitting of ATP, the fuel of every cell. In this process, the two strands move in opposing directions, albeit only a few nanometers. The TUM groups of Prof. Thorsten Hugel from the Department of Physics and Prof. Johannes Buchner from the Department of Chemistry are quite familiar with the movement of Hsp90: They were the first to observe the scissor-like movement in real-time. Yet even they were caught off guard: Instead of the familiar one-ended scissor movement at the N terminal domains they were now observing the rocking movement at both ends of the protein.

Hsp90 opens and closes in a scissors-like manner at the C terminal as well
'/>"/>

Contact: Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... MALVERN, PA (PRWEB) March 26, 2015 ... leading providers of continuing medical education, the ... for Culinary Medicine at Tulane University are ... in Culinary Medicine. The interdisciplinary program ... Specialist (CCMS) credential, is designed for physicians, nurse ...
(Date:3/26/2015)... “The SWEET Act is an important step to ... and help parents who are working to reduce sugar in ... to support public health, and we will continue to stand ... of all families,” said Dr. Jane Delgado President and CEO ... of the Sugar-Sweetened Beverage Tax (SWEET) Act by Congresswoman Rosa ...
(Date:3/26/2015)... Saving Moses is a global humanitarian ... needed but least available. As one of their staple ... in the Benguela province of Angola to treat babies ... visit to their clinics, staff employed the art of ... babies in a nation the The New York Times ...
(Date:3/26/2015)... Frencisco, CA (PRWEB) March 26, 2015 ... Center are proud to announce expanded offerings for Bay ... San Francisco Dental Implant Center has long been a ... have expanded its offerings to meet the strong demand ... in our reputation as a top-rated dental implant facility ...
(Date:3/26/2015)... San Juan Capistrano, Calif. (PRWEB) March 26, 2015 ... monitoring equipment and repairs, is pleased to be featured ... the Discovery Channel on March 18, 2015. The ... status, and it is live on the Pacific Medical ... families that face life threatening emergencies, it is reassuring ...
Breaking Medicine News(10 mins):Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 2Health News:Certified Culinary Medicine Specialist Program Jointly Launched by Goldring Center for Culinary Medicine at Tulane University and Cardiometabolic Risk Summit 3Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act in 114th Congress 2Health News:Saving Moses Utilized Photography in an Effort to Engage Mothers and Their Babies on a Recent Visit to Angola 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 2Health News:Bay Area Dental Implant Specialist, Dr. Alex Rabinovich Announces Regional Educational Strategy 3Health News:Pacific Medical Featured on the Discovery Channel 2Health News:Pacific Medical Featured on the Discovery Channel 3
... But Canadian study finds increase in non-serious side effects ... contain compounds called cannabinoids from the marijuana plant don,t ... associated with an increase in some non-serious side effects, ... in Montreal and the University of British Columbia (UBC) ...
... its wholly-owned subsidiary Embryome Sciences, Inc. announced ... International Embryome Initiative, an international collaboration with ... first systematic map of all the cell ... In a paper published today titled “The ...
... cellular ... analysis capabilities, ... a leader in innovative solutions for drug discovery and ... (Sunnyvale, CA) for $13 million. The acquisition,of Blueshift Biotechnologies, ...
... latest,report by the American Lung Association, Lung Disease Data, ... death rates due to other,leading causes of death such ... pulmonary disease (COPD) is expected to,become the third leading ... Association publishes Lung Disease Data to serve as a,resource ...
... Accelera Recognised as Key Partner in the Development of ... treatment of African,trypanosomiasis, commonly known as "sleeping sickness", by ... business unit of,Nerviano Medical Sciences (NMS), is to be ... The award will be conferred today in New York, ...
... Community in Hydration and Sanitation, Sand Bag , ... ... students assisted Missouri community residents who were impacted by raging ... students ensured that Clarksville families were educated on proper sanitation, the ...
Cached Medicine News:Health News:Drugs With Marijuana Compounds Don't Boost Adverse Events 2Health News: BioTime, Inc. and Embryome Sciences, Inc. Launch Embryome.com and the International Embryome Initiative 2Health News: BioTime, Inc. and Embryome Sciences, Inc. Launch Embryome.com and the International Embryome Initiative 3Health News: BioTime, Inc. and Embryome Sciences, Inc. Launch Embryome.com and the International Embryome Initiative 4Health News:MDS Analytical Technologies Acquires Blueshift Biotechnologies 2Health News:American Lung Association Report Finds Lung Disease Death Rates Increasing While Cancer, Heart Disease and Stroke Death Rates Are Decreasing 2Health News:American Lung Association Report Finds Lung Disease Death Rates Increasing While Cancer, Heart Disease and Stroke Death Rates Are Decreasing 3Health News:The "DNDi Project of the Year": The Development of Fexinidazole to Treat "Sleeping Sickness" 2Health News:Sanford-Brown College Students Help in Missouri Flood Relief 2
(Date:3/26/2015)... , March 26, 2015 ... announced the addition of the "Global Smart ... report to their offering.      (Logo: ... Wearable Healthcare Devices and Services market to grow ... 2015-2019 The report covers the present ...
(Date:3/26/2015)... 26, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX)("the Company" ... patent acceptance notice from the Israeli patent office with ... or reduce tissue damage caused by an increase in ... vessels are opened after a blockage causing a heart ... Damage can be caused to the heart ...
(Date:3/26/2015)... N.J. , March 26, 2015  Becton, Dickinson ... that it will commence offers to exchange all validly ... by CareFusion Corporation, a wholly owned subsidiary of BD, ... in the table below. A Registration Statement on Form ... the New Notes was filed with the Securities and ...
Breaking Medicine Technology:Global Smart Wearable Healthcare Devices and Services Market 2015-2019 WITH Apple, At&T, Ee, Google, Samsung, Sprint, Telefonica & T-Mobile Dominating 2RegeneRx Receives Israeli Patent Acceptance Notice for the Use of TB4 To Prevent Tissue Damage Associated with Heart Attack and Stroke Treatments 2RegeneRx Receives Israeli Patent Acceptance Notice for the Use of TB4 To Prevent Tissue Damage Associated with Heart Attack and Stroke Treatments 3Becton, Dickinson and Company to Commence Exchange Offers 2Becton, Dickinson and Company to Commence Exchange Offers 3Becton, Dickinson and Company to Commence Exchange Offers 4Becton, Dickinson and Company to Commence Exchange Offers 5
... samples to be used to identify molecular,signature of ... ALS Therapy,Development Institute (ALS TDI) announced today ... samples collected through an expanded network,of clinical partnerships. ... effort to indentify the altered expression of genes,and ...
... Vical Incorporated,(Nasdaq: VICL ) today ... a leading European medical university, and the ... governmental expert agency, to,evaluate Vical,s Vaxfectin(R) adjuvant ... Medical Technologies Inc.,OTCBB:BJCT) for a multivalent preventive ...
Cached Medicine Technology:ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease 2ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease 3Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control 2Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control 3Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control 4Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control 5
Gerl tying forceps, titanium, with 0.12 mm teeth....
Castroviejo tying forceps, tying platforms, straight, 0.3 mm teeth....
Shepard tying forceps, round curved platform 8 mm, 8.5 cm....
Girard angled tying forceps made of titanium has angled 45 shafts with 4 mm tying platforms, width of shafts 0,25 mm, TCI platforms, round handle, diam. 6 mm, overall length 102 mm....
Medicine Products: