Navigation Links
Multivitamin use may offer no benefit in postmenopausal women
Date:2/9/2009

February 9, 2009 (BRONX, NY) The largest study ever conducted on postmenopausal women shows that multivitamins may offer no benefit in reducing the risk of common cancers, cardiovascular disease or overall mortality. The study, published today in Archives of Internal Medicine, also shows that multivitamins do not increase the risk for these conditions.

The research was conducted as part of the Women's Health Initiative Clinical Trials and the Women's Health Initiative (WHI) Observational Study. Combined, the two studies include data from 161,808 postmenopausal women ages 50 to 79. Of that group, 41.5 percent used multivitamins over 15 study years. This latest study found no overall associations between multivitamin use and breast, colorectal, endometrial, kidney, bladder, stomach, ovary, or lung cancer. Researchers also found no association between multivitamin use and cardiovascular disease and death.

The study was led by Marian L. Neuhouser, Ph.D., R.D., of the Fred Hutchinson Cancer Research Center in Seattle, Washington, in conjunction with others from national WHI clinical centers, including Sylvia Wassertheil-Smoller, Ph.D., professor of epidemiology and population health at Albert Einstein College of Medicine of Yeshiva University. Dr. Wassertheil-Smoller is the principal investigator of the WHI study at Einstein.

Researchers collected data for the multivitamin study during participants' clinic visits. Clinic staff transcribed the ingredients for each supplement, and then grouped them according to three classifications. The most common category (35 percent) was multivitamins with minerals, followed by multivitamins alone (3.5 percent) and stress multivitamins (2.3 percent).

"Based on our results, if you fall into the category of the women described here, and you do in fact have an adequate diet, there really is no reason to take a multivitamin," explained Dr. Wassertheil-Smoller.

According to the most recent information from the National Institutes of Health published in Archives of Internal Medicine, more than half of Americans use supplements; over $20 billion is spent annually on dietary supplements, with more than one-third of this amount spent on multivitamins. The National Health and Nutrition Examination Surveys show that women are more likely than men to take supplements, and the number of women taking supplements increases steadily among women 30 years of age and up.

Information on whether multivitamins promote health benefits or risks can be confusing to consumers. Clinical studies show folic acid can offer protection from birth defects for women of childbearing age, while other studies suggest antioxidants, especially beta-carotene among smokers, could increase cancer risk.

The WHI study authors acknowledge the potential limitations of their study, and caution against extrapolating their results to the general public. For example, the cohort of women participating in the study was relatively well-educated and had better health habits. Approximately 40 percent had a college degree or higher, and at least 80 percent finished high school.

"What this paper shows is that multivitamin use just doesn't seem to make that much of a difference in this population," says Dr. Wassertheil-Smoller. "It confers no additional benefit but it also does no harm."

Despite the large number of study participants, the researchers emphasize the need for more definitive randomized control trials on multivitamin use. Randomized control studies (RCS) compare treatment groups with placebo groups and are considered the gold standard in clinical research. The first ongoing RCS on multivitamin use in men will be completed in 2012. That study, the Physician's Health Study, looks at thousands of male physicians and compares a commonly used multivitamin, Centrum Silver, to placebo.

"What is encouraging now is that there is a scientific focus on the biological and physiological mechanisms through which these vitamins and minerals work. I am really curious to see their results," Dr. Wassertheil-Smoller said.

Dr. Wassertheil-Smoller does not think another randomized control study, on women for example, will be done until after results from the men's study are completed and the findings are published.

The paper, "Multivitamin Use and Risk of Cancer and Cardiovascular Disease in the Women's Health Initiative Cohorts" appears in the February 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.


'/>"/>

Contact: Michael Heller
sciencenews@aecom.yu.edu
718-430-4186
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Excessive Multivitamin Use May Raise Risk for Prostate Cancer, from Harvard Mens Health Watch
2. Its Time to Reassess the Value, Safety of Multivitamin Use, Says Harvard Mens Health Watch
3. Leiner Health Products Issues Allergy Alert on Undeclared Allergens in Liquimax(R) Multivitamin
4. Vitalize(TM) Receives Top Multivitamin Rating
5. Brides-To-Be Should Say I Do to a Daily Multivitamin With Folic Acid
6. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
7. Health care incentive model offers collaborative approach
8. Eye-staining technique offers early detection for dry eye syndrome
9. Governor Rendell Offers adultBasic Coverage to 35,000 Uninsured Pennsylvanians
10. Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Mercks Generic Pharmaceutical Business
11. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
Breaking Medicine Technology: