Navigation Links
Multiple sclerosis will become a controlled disease like AIDS
Date:10/28/2010

The complexity of the immune system and nervous system turn Neuroimmunology into one of the most exciting fields of modern biomedicine. Between October 26th and 30th takes place in Sitges (Barcelona, Spain) the X International Congress of Neuroimmunology of the International Society of Neuroimmunology. This event highlights the advances that have been made in recent years thanks to new technologies, but also highlights the long road ahead. New biomarkers, potential immunotherapies, stem cell strategies and new discoveries about the natural history of neuroimmunological diseases are some of the issues that focus the attention of the 1,000 scientists attending the Congress.

Multiple Sclerosis is one of the most well known study area of Neuroimmunology. This autoimmune disease causes demyelination of neurons that leads to a neurodegenerative process. Recent studies of association with whole genome data have identified about 20 genes associated with susceptibility to develop the disease. Scientific community estimates that in the next 2 years there will be around 80 associated genes that will make a very accurate picture of the disease genetic basis. Systems biology, which uses computer models to analyze complex biological processes, complements these studies integrating genetic, molecular, physiological and clinical information.

The tools of high-throughput sequencing and genotyping, along with innovative brain imaging techniques that improve phenotypic characterization of the disease, combine to further define the set of involved genes. Neuroinflammation and the mediators that cause neuronal demyelination are two processes gaining interest in research. Already available drugs are being successful in the fight against neuroinflammation, and many scientists believe that when the disease is diagnosed at an early stage it will soon become a controlled disease, as has been achieved with AIDS.

Unfortunately, strategies to regenerate damaged tissue are missing. Cell therapies have been applied successfully in hemato-oncological diseases and experimental results have enabled the first clinical studies to apply treatments with different types of regenerative stem cells to Multiple Sclerosis. Pharmacogenomics is another way to improve treatments, trying to predict which patients will respond better to one treatment or another.

On the other hand, Congress is also providing data on the effects of infections and cancer in the nervous system. Some common cancers, including breast, ovarian or lung cancer, express proteins found only in the brain in normal conditions. The immune system combats tumor generating antibodies against these proteins, thus causing adverse effects in the brain when the antibodies cross the blood brain barrier. Those antibodies could cause an alteration of neuronal function leading to motor dysfunction, behavioral disorders or dementia. Identifying the cause of these neuronal dysfunctions has made possible the first treatment for a group of patients with a poor prognosis so far.

Experts will present their latest results and discuss the next steps during the Congress held in Sitges (Barcelona, Spain). It has brought together internationally renowned scientists, such as Dr. Stephen L. Hauser, from the University of California - San Francisco (UCSF) Multiple Sclerosis Center, and Dr. Josep Dalmau, from the University of Pennsylvania (Philadelphia, USA) and future IDIBAPS - Hospital Clnic of Barcelona researcher where he will join the Multiple Sclerosis Group Dr. Pablo Villoslada, coordinator of Congress, is already working. These and many other researchers will work in the next years to improve knowledge and efficiency in the fight against neuroimmunological diseases.


'/>"/>

Contact: lex Argem
aargemi@clinic.ub.es
34-932-275-700
IDIBAPS - Institut d'Investigacions Biomdiques August Pi i Sunyer
Source:Eurekalert

Related medicine news :

1. Radiation therapy improves painful condition associated with multiple sclerosis
2. TGen-Mayo Clinic study discovers role of DNA methylation in multiple myeloma blood cancer
3. Results of the placement of multiple endoscopic stents for postoperative biliary strictures remains excellent after long-term follow-up
4. Clinic puts patients at heart of multiple sclerosis research
5. Multiple Sclerosis Changes With the Seasons
6. New studies question vascular multiple sclerosis hypothesis and treatment
7. Multiple sclerosis -- antihypertensive drug ameliorate inflammation in the brain
8. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
9. University at Buffalo launches clinical trial of new multiple sclerosis treatment
10. Clinical Trial Testing New Multiple Sclerosis Treatment to Launch in Buffalo
11. Cancer and Multiple Sclerosis Survivor Martin Smith's 3,000-mile Bicycle Ride Benefits Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... MEDI+SIGN®, a provider ... that a new solution for Emergency Departments (ED) has been added to their ... Emergency Department examination rooms, and with a simplified pallet of information available to ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... with distinction by the Undersea and Hyperbaric Medical Society (UHMS), the leading authority ... care and patient safety. Only a few hospitals and facilities have earned this ...
(Date:12/8/2016)... ... December 08, 2016 , ... Seavest ... Property owned by an affiliate of Seavest, has won a prestigious national healthcare ... Chester County ambulatory care center (ACC) was named “Best New Development, MOBs and ...
(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman , ... Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont ... and attorneys from the firm’s global Life Sciences & Medical Technology Group have been ...
(Date:12/8/2016)... ... 2016 , ... Catalent Pharma Solutions, the leading global provider ... products, today announced that it had joined the Pharmaceutical Supply Chain Initiative (PSCI). ... unite pharmaceutical and healthcare companies that share a vision of better, social, environmental ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 KEY FINDINGS ... the largest share of the market in 2016 and ... dominance can be attributed to a large number of ... (US hold the largest share in the patient temperature ... benefits such as reducing loss of blood during surgeries, ...
(Date:12/8/2016)... 8, 2016 Research and Markets has announced ... Trends - Adhesion Type, Application, Usability - Forecast to 2025" ... , ... Market is poised to grow at a CAGR of around 3.2% ... market is witnessing include advancements in extracellular microelectrode arrays and intracellular ...
(Date:12/8/2016)... Quebec , Dec. 8, 2016  Valeant ... and TSX: VRX) ("Valeant") today announced positive results ... clinical study to assess the safety and efficacy ... the treatment of plaque psoriasis. ... subjects with moderate to severe psoriasis, IDP-118 showed ...
Breaking Medicine Technology: