Navigation Links
Multiple sclerosis progression can be predicted with MRI
Date:11/5/2008

Boston, Mass. November 05, 2008 A new study published in Journal of Neuroimaging shows that MRI scans used on multiple sclerosis (MS) patients to determine if the disease has affected gray matter in the brain can identify those at-risk for progression of disability.

MS affects approximately 400,000 people in the United States and as many as 2.5 million worldwide. It is the most common cause of progressive disability in young adults. While the cause of the disease remains unknown, it is characterized by damage to the covering over the nerve fibers in the brain and spinal cord, or to the nerve fiber itself.

In an attempt to understand the causes of disease progression, researchers at the Partners MS Center, led by Dr. Rohit Bakshi and his team, have developed new ways to detect gray matter damage.

Dr. Bakshi, Director of the Laboratory for Neuroimaging Research and an Associate Professor of Neurology and Radiology at the Brigham and Women's Hospital and Harvard Medical School, led a four year follow-up study, which found that patients with unnatural darkness of gray matter structures as seen on MRI pictures carried a higher risk for progression of physical disability. This abnormal darkness is referred to as T2 hypointensity, and is suggestive of excessive iron deposits. In addition, the researchers found that the new marker of gray matter damage showed closer correlations with patients' clinical status than other established MRI markers of disease severity, including lesions, also known as "plaques," and shrinkage of the brain, also know as "atrophy."

"MRI scans obtained from patients with MS are being used to develop measures and techniques that can accurately measure the visible and hidden damage to the brain, especially in gray matter areas and can more accurately predict the course of the disease," says Bakshi.

As a result of the findings, MRI-based measurement of gray matter damage may be used as a surrogate marker of disease progression. Physicians may therefore be able to more accurately identify patients at risk for developing this progressive disease.

MS has been traditionally viewed as a disease affecting the white matter of the brain, where messages are transferred between the brains gray matter sections, which control the processing of information. While prior research has shown that the brain's gray matter is also affected, studies detailing its effects have been limited. In addition, current therapies for MS are incomplete, raising the need to better understand disease mechanisms and the biomarkers of disease progression. If excessive iron in gray matter contributes to damage, this would open a new avenue for developing better therapies.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Multiple Sclerosis Association of Americas Resource Detectives(SM) Program Marks One Year Anniversary
2. Venables Election Watch Group Assesses Presidential Elections Impact on Multiple Industries
3. New Analyses Confirm Nexavars Efficacy and Safety in Multiple Patient Subsets With Liver Cancer
4. Results From IMPROVE Study Show Therapeutic Effect of New Formulation of Rebif(R) at 16 Weeks in Patients With Multiple Sclerosis
5. Nanomedical approach targets multiple cancer genes, shrinks tumors more effectively
6. UTMB researchers test new vaccine to fight multiple influenza strains
7. New method to overcome multiple drug resistant diseases developed by Stanford researchers
8. Treatment with anti-anemia drugs may not be safe for multiple myeloma patients
9. Air Ambulance Company AirMed International Wins Multiple "Best in Business" Awards from Birmingham Business Journal
10. How molecules out of balance lead to human multiple myeloma and other cancers
11. Caffeine Could Stave Off Multiple Sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... ... America for the scientific development, healthcare training and clinical application of medical infrared ... becoming certified to perform medical thermal imaging services. , The first new educational ...
(Date:5/22/2017)... Minn. (PRWEB) , ... May 22, 2017 , ... “Homeostasis: ... man’s experience learning to live with Bipolar 1. Donald Rodriguez takes readers on a ... in Alaska in the dead of winter and to a dark place where Donald ...
(Date:5/21/2017)... York, NY (PRWEB) , ... May 19, 2017 , ... Chris Cornell, 52, was found ... or imagine why one of the most respected lead singers in the rock industry would ... a history of mental illness. FindaTopDoc investigates how mental illness played a role in the ...
(Date:5/21/2017)... , ... May 21, 2017 , ... ... has brought together a cross-disciplinary group of scholars, policymakers, and activists wanting to ... Justice, and Equity is the third book from a recent series of ...
(Date:5/19/2017)... ... ... In a continuous effort to raise awareness of autism and common toxins ... in natural and organic latex mattresses, has announced that they will donate $1 to ... their recent viral Facebook video receives, up to $10,000.00. , The luxury ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... BOTHELL, Wash. , May 4, 2017   ... a leading developer, manufacturer and marketer of proprietary clinical ... media ("BioLife" or the "Company"), today announced that ... released after market close on Thursday, May 11, 2017, ... and live webcast at 1:30 p.m. PT that afternoon. ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
(Date:5/3/2017)... May 3, 2017  West Pharmaceutical Services, Inc. ... for injectable drug administration, announced today that ... Technical Services, and Diane Paskiet , Director, ... presentations focused on West,s expertise in the areas ... well as providing commentary on updated industry guidance. ...
Breaking Medicine Technology: