Navigation Links
Multiple corticosteroid injections in pregnant women may increase cerebral palsy
Date:9/21/2007

CHAPEL HILL -- When pregnant women are at high risk for preterm birth, giving them a single injection of corticosteroids has been shown to reduce the babys chances of having serious lung problems after birth.

But some women receive multiple injections of corticosteroids, and a new study shows that repeat courses of corticosteroids are linked to an increased rate of cerebral palsy among children of these mothers.

Our study shows that you get almost all of the benefit from a single round of therapy and that multiple rounds raise the risk of cerebral palsy, which is a severely disabling condition, said John M. Thorp, M.D., a study co-author and McAllister distinguished professor of obstetrics and gynecology at the University of North Carolina at Chapel Hill School of Medicine.

Thats why we concluded that exposure to repeat courses should be limited, Thorp said.

The study results are published in the Sept. 20, 2007, issue of the New England Journal of Medicine. The lead author is Ronald J. Wapner, M.D., of Drexel University in Philadelphia. The study was conducted for the Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development, which provided grant funding. Research took place at 14 sites across the United States, including UNC-Chapel Hill.

The researchers followed women between 23 weeks and 32 weeks pregnant who remained pregnant after an initial dose of corticosteroids. They were randomly assigned to receive weekly courses of the corticosteriod betamethasone or placebo injections.

Children born to women enrolled in the study were given physical and neurological examinations at ages 2 to 3 years old. A total of 556 children were examined. Of these, 486 (87.4 percent) had physical exams and 465 (83.6 percent) were evaluated for brain function using a measurement tool called the Bayley Scales of Infant Development.

The researchers found that there were no meaningful differences in weight, head circumference or Bayley scores between children whose mothers received a single dose of corticosteroids. However, six children in the group whose mothers received multiple injections had cerebral palsy, compared to only one child in the placebo group.

Although not statistically significant, the rate of cerebral palsy in infants exposed to multiple courses is of concern and suggests that exposure to repeat courses of antenatal corticosteroids should be limited, the researchers concluded.

The Sept. 20 issue also includes a separate study that examined the same question and an editorial that discusses both studies. The editorial was written by Alan D. Stiles, M.D., Brewer distinguished professor and chairman of pediatrics in the UNC School of Medicine.

The other study reached similar results, with one key difference: the researchers found smaller head sizes among the infants exposed to repeat courses of corticosteroids. But the study authors reached a different conclusion from Thorp and his co-authors, in favor of using repeat courses.

In the editorial, Stiles noted that both studies found that repeat courses produced better results than single courses in terms of reducing lung problems in the infants. However, both studies also found lower birth weights in the infants exposed to repeat courses.

More information is needed before it is clear which strategy is optimal, Stiles wrote. Further study is warranted of school-age neurodevelopmental performance, including the possible increased risk of cerebral palsy among these children, as well as among offspring of women in other trials of weekly corticosteroid therapy, with attention to the doses used.


'/>"/>

Contact: Stephanie Crayton
scrayton@unch.unc.edu
919-966-2860
University of North Carolina at Chapel Hill
Source:Eurekalert

Related medicine news :

1. Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
2. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
3. Plasma Exchange Of No Use In Multiple Myeloma
4. Multiple Sclerosis Can Be Treated By Blocking Fat Hormone
5. Multiple organ disease cured by genes
6. Associated therapy for multiple myeloma
7. Latest drug shows promise in multiple myeloma
8. Adult stem cells in treatment for Multiple sclerosis (MS)
9. Life Quality For Patients With Multiple Sclerosis
10. Effective Pain Relief For Patients Suffering From Multiple Sclerosis
11. The Link Between Hepatitis B Vaccine And Multiple Sclerosis Questioned
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... ... staff members in 2017 who are passionate about making a difference in the ... and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more than ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Sam & Associates ... to commercial and residential clients in the California Bay Area, is launching a charity ... in the region. , Heart disease is the primary killer of adult men and ...
(Date:1/19/2017)... ... January 19, 2017 , ... Tribble Insurance Agency, a ... eastern Virginia region, is inaugurating a charity event to honor Chad Phillip Dermyer, a ... duty last year, Chad Phillip Dermyer and his fellow officers were conducting routine stops ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... St. Catherine’s ... Center. , Siena Center is a skilled nursing facility on the grounds of the ... semiprivate rooms. It recently was voted the best nursing home in Mississippi for the ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... 2017 Spring Create Real Impact contest from Impact Teen Drivers and California Casualty. ... http://www.createrealimpact.com . , Educational grants totaling $15,000 will be awarded for the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017  Abaxis, Inc. (NasdaqGS: ABAX ), ... and consumables for the medical and veterinary markets worldwide, ... results for the third quarter fiscal year 2017, ended ... p.m. ET on Thursday, January 26, 2017.  The Company ... year 2017 after the market closes on Thursday, January ...
(Date:1/19/2017)... -- Shire plc (LSE: SHP, NASDAQ: ... Drug Administration (FDA) has acknowledged receipt of the Class ... SHP465, a long-acting, triple-bead, mixed amphetamine salts formulation. SHP465 ... Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is expected to provide ... designated Prescription Drug User Fee Act (PDUFA) action date. ...
(Date:1/19/2017)... January 19, 2017 While ... serious about reducing the FDA,s regulatory strictness as ... the medical drug industry, many of the leading ... clinical trials and development of advanced drug treatments ... with recent developments include:  Moleculin Biotech, Inc., (NASDAQ: ...
Breaking Medicine Technology: