Navigation Links
Multiple Doses of Steroids Don't Help Preemies
Date:12/18/2008

More than one course can lead to smaller babies, study says

THURSDAY, Dec. 18 (HealthDay News) -- Pregnant women at risk of preterm delivery who are given multiple doses of steroids to help their fetus tend to give birth to low birth-weight babies with smaller head circumference, a new study found.

A single dose of corticosteroids had been the standard of care for many years to reduce the chances of infant mortality, respiratory distress syndrome, and bleeding in the brain. And, it was thought that women who remained at risk of preterm birth after an initial dose would benefit from repeated doses.

"A single course of steroids is given to all women at risk of preterm birth, and that still holds," said study lead author Dr. Kellie E. Murphy, who's with Mount Sinai Hospital's Department of Obstetrics and Gynaecology, in Toronto, Canada.

"The results of this trial will change clinical practice worldwide," she said. "It will conclusively stop practitioners from giving multiple courses of antenatal corticosteroids."

The report was published in the Dec. 20/27 issue of The Lancet.

Dr. William F. Walsh, chief of nurseries and a specialist in the care of high-risk newborn babies at Vanderbilt University Medical Center in Nashville, said clinical practice has already changed, and most doctors only give a single dose of steroids.

"Every research has shown an overwhelming benefit from one course of steroids for premature babies," he said, adding that multiple doses are no better than one.

"It's an important question to answer, but I thought it had already been answered," Walsh said.

For the new research, Murphy and her colleagues studied 1,858 women at 25 to 32 weeks of gestation who had not delivered their babies within 14 to 21 days after receiving one dose of corticosteroids.

The women were randomly assigned to corticosteroids every 14 days until 33 weeks of gestation or until they delivered, or a placebo. The researchers looked for cases of death before or after delivery and other conditions, such as severe respiratory distress syndrome and bleeding in the brain.

Murphy's team found that women given multiple doses of corticosteroids had babies that weighed less, were shorter and had smaller head circumference than babies of mothers given a placebo.

Also, there was no difference in other results, such as death, respiratory problems and bleeding in the brain between the babies of women given more than one dose of steroids and women given a placebo, the researchers reported.

More information

For more on premature infants, visit the U.S. National Library of Medicine.



SOURCES: Kellie E. Murphy, M.D., Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada; William F. Walsh, M.D., chief, nurseries, pediatrics, neonatology, Vanderbilt University Medical Center, Nashville, Tenn.; Dec. 20/27, 2008, The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. New MRI finding sheds light on multiple sclerosis disease progressio
3. Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium
4. Emory researchers identify signaling protein for multiple myeloma
5. Study suggests brain tumors need treatment with multiple targeted drugs
6. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
7. Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
8. Multiple corticosteroid injections in pregnant women may increase cerebral palsy
9. Multiple Sclerosis Patients Find Dietary Treatment More Effective Than Pharmaceutical Regimens
10. IVF technique enables pregnancy without multiple births, Stanford researchers find
11. Ingenious Med Forms Multiple Billing Company Partnerships to Market Inpatient Practice Management Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Michael Vick ... and transforming the quarterback position. The former overall number one pick in the 2001 ... football career. He holds the record for the most career rushing yards by a ...
(Date:4/24/2017)... ... April 24, 2017 , ... The bar for just about everything—apparel, eyewear, cars ... rarified air of pop and film stardom.(1) Not to be left out is that ... Grins now run the gamut from being encrusted with jewels and precious metals to, ...
(Date:4/24/2017)... ... ... The John P. McGovern Museum of Health and Medical Science is now ... health, and share results with their physicians. Members and guests can sign up for ... BrainCheck founder, Dr. David Eagleman, formerly at Baylor College of Medicine and now at ...
(Date:4/24/2017)... TEXAS (PRWEB) , ... April 24, 2017 , ... ... (SaaS) based healthcare compliance and credentialing solutions, today announced that Kyle Allain has ... leads symplr’s Cactus Provider Management sales and operations, including provider, payor and managed ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... health of individuals with HIV because it is not known to have significant ... have favorable effects to both lower cholesterol levels and dampen inflammation in the ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 Companion animal ... in pets such as canine, avian and feline. ... types such as Attenuated Live Vaccines, Conjugate Vaccines, ... and Recombinant Vaccines. Attenuated live vaccines are derived ... which have been weakend under laboratory conditions. Conjugate ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, ... on providing the Urology, Uro/Gyn and Gynecology markets with ... the first quarter ended March 31, 2017 after the ... The Company will host a conference call and ... on Tuesday, May 2, 2017 at 4:30 p.m. Eastern ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc. ... collaboration started in 2016, in which Socionext extracts ... SOINN". The companies achieved initial results in reading ... by Artificial Brain SOINN. The results will be ... Sight, April 19-21, at booths 4505 & 4507. ...
Breaking Medicine Technology: