Navigation Links
Multiple Doses of Steroids Don't Help Preemies
Date:12/18/2008

More than one course can lead to smaller babies, study says

THURSDAY, Dec. 18 (HealthDay News) -- Pregnant women at risk of preterm delivery who are given multiple doses of steroids to help their fetus tend to give birth to low birth-weight babies with smaller head circumference, a new study found.

A single dose of corticosteroids had been the standard of care for many years to reduce the chances of infant mortality, respiratory distress syndrome, and bleeding in the brain. And, it was thought that women who remained at risk of preterm birth after an initial dose would benefit from repeated doses.

"A single course of steroids is given to all women at risk of preterm birth, and that still holds," said study lead author Dr. Kellie E. Murphy, who's with Mount Sinai Hospital's Department of Obstetrics and Gynaecology, in Toronto, Canada.

"The results of this trial will change clinical practice worldwide," she said. "It will conclusively stop practitioners from giving multiple courses of antenatal corticosteroids."

The report was published in the Dec. 20/27 issue of The Lancet.

Dr. William F. Walsh, chief of nurseries and a specialist in the care of high-risk newborn babies at Vanderbilt University Medical Center in Nashville, said clinical practice has already changed, and most doctors only give a single dose of steroids.

"Every research has shown an overwhelming benefit from one course of steroids for premature babies," he said, adding that multiple doses are no better than one.

"It's an important question to answer, but I thought it had already been answered," Walsh said.

For the new research, Murphy and her colleagues studied 1,858 women at 25 to 32 weeks of gestation who had not delivered their babies within 14 to 21 days after receiving one dose of corticosteroids.

The women were randomly assigned to corticosteroids every 14 days until 33 weeks of gestation or until they delivered, or a placebo. The researchers looked for cases of death before or after delivery and other conditions, such as severe respiratory distress syndrome and bleeding in the brain.

Murphy's team found that women given multiple doses of corticosteroids had babies that weighed less, were shorter and had smaller head circumference than babies of mothers given a placebo.

Also, there was no difference in other results, such as death, respiratory problems and bleeding in the brain between the babies of women given more than one dose of steroids and women given a placebo, the researchers reported.

More information

For more on premature infants, visit the U.S. National Library of Medicine.



SOURCES: Kellie E. Murphy, M.D., Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada; William F. Walsh, M.D., chief, nurseries, pediatrics, neonatology, Vanderbilt University Medical Center, Nashville, Tenn.; Dec. 20/27, 2008, The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. New MRI finding sheds light on multiple sclerosis disease progressio
3. Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium
4. Emory researchers identify signaling protein for multiple myeloma
5. Study suggests brain tumors need treatment with multiple targeted drugs
6. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
7. Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
8. Multiple corticosteroid injections in pregnant women may increase cerebral palsy
9. Multiple Sclerosis Patients Find Dietary Treatment More Effective Than Pharmaceutical Regimens
10. IVF technique enables pregnancy without multiple births, Stanford researchers find
11. Ingenious Med Forms Multiple Billing Company Partnerships to Market Inpatient Practice Management Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and Chris ... spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation continuing ... the program, private practitioners receive cutting-edge clinical training and learn how to perform ...
(Date:5/24/2017)... ... ... Myers Jackson is well known for auctioning homes that people move and flip. ... planet. The luxury home market is alive and well and there are mansions for ... “11 Spyglass Hill Auction will enlighten you on the dynamics of how to market ...
(Date:5/24/2017)... ... 2017 , ... Accordant Technology, a trusted IT solutions provider, ... analytics-first approach, layered with machine learning, that provides real-time visibility into the performance, ... to the edge. Through the new partnership, customers get the real-time situational insight ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... and nonprofit hospitals and health systems in the nation and help their organizations ... led professional organizations and been instrumental in developing successful hospital and health system ...
(Date:5/23/2017)... ... May 23, 2017 , ... MDLand International (MDLand), a ... today that its iClinic V12.2 solution has achieved approval from National Center for ... PCMH 2017 standards which emphasize team-based care with a significant focus on the ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... Provista , a proven leader in the supply chain industry ... Jim Cunniff as the company,s new president and CEO. ... Provista, including most recently serving as the president and CEO ... He assumed his new role with Provista on May 1, ... says Jody Hatcher , president, Sourcing and Collaboration Services ...
(Date:5/4/2017)... , May 4, 2017 Clarius ... its wireless, handheld ultrasound scanners this week at ... Scientific Meeting (ACOG) in San Diego, ... "Clarius is the perfect tool for ... and heart rate, and evaluate pregnancy-related complications like ...
(Date:5/3/2017)... , May 3, 2017 A Catheterization ... hospital or healthcare facility. Commonly referred to as ... equipped with diagnostic imaging technology to give physicians ... heart. In these spaces, a team of physicians ... angioplasty, percutaneous coronary intervention, congenital heart defect closure, ...
Breaking Medicine Technology: