Navigation Links
Multiple Doses of Steroids Don't Help Preemies
Date:12/18/2008

More than one course can lead to smaller babies, study says

THURSDAY, Dec. 18 (HealthDay News) -- Pregnant women at risk of preterm delivery who are given multiple doses of steroids to help their fetus tend to give birth to low birth-weight babies with smaller head circumference, a new study found.

A single dose of corticosteroids had been the standard of care for many years to reduce the chances of infant mortality, respiratory distress syndrome, and bleeding in the brain. And, it was thought that women who remained at risk of preterm birth after an initial dose would benefit from repeated doses.

"A single course of steroids is given to all women at risk of preterm birth, and that still holds," said study lead author Dr. Kellie E. Murphy, who's with Mount Sinai Hospital's Department of Obstetrics and Gynaecology, in Toronto, Canada.

"The results of this trial will change clinical practice worldwide," she said. "It will conclusively stop practitioners from giving multiple courses of antenatal corticosteroids."

The report was published in the Dec. 20/27 issue of The Lancet.

Dr. William F. Walsh, chief of nurseries and a specialist in the care of high-risk newborn babies at Vanderbilt University Medical Center in Nashville, said clinical practice has already changed, and most doctors only give a single dose of steroids.

"Every research has shown an overwhelming benefit from one course of steroids for premature babies," he said, adding that multiple doses are no better than one.

"It's an important question to answer, but I thought it had already been answered," Walsh said.

For the new research, Murphy and her colleagues studied 1,858 women at 25 to 32 weeks of gestation who had not delivered their babies within 14 to 21 days after receiving one dose of corticosteroids.

The women were randomly assigned to corticosteroids every 14 days until 33 weeks of gestation or until they delivered, or a placebo. The researchers looked for cases of death before or after delivery and other conditions, such as severe respiratory distress syndrome and bleeding in the brain.

Murphy's team found that women given multiple doses of corticosteroids had babies that weighed less, were shorter and had smaller head circumference than babies of mothers given a placebo.

Also, there was no difference in other results, such as death, respiratory problems and bleeding in the brain between the babies of women given more than one dose of steroids and women given a placebo, the researchers reported.

More information

For more on premature infants, visit the U.S. National Library of Medicine.



SOURCES: Kellie E. Murphy, M.D., Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada; William F. Walsh, M.D., chief, nurseries, pediatrics, neonatology, Vanderbilt University Medical Center, Nashville, Tenn.; Dec. 20/27, 2008, The Lancet


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. New MRI finding sheds light on multiple sclerosis disease progressio
3. Genomic Health Announces Multiple Studies on Oncotype DX(TM) Presented at 2007 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium
4. Emory researchers identify signaling protein for multiple myeloma
5. Study suggests brain tumors need treatment with multiple targeted drugs
6. Gene profiling can single out the worst cases of multiple myeloma and guide therapy
7. Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients
8. Multiple corticosteroid injections in pregnant women may increase cerebral palsy
9. Multiple Sclerosis Patients Find Dietary Treatment More Effective Than Pharmaceutical Regimens
10. IVF technique enables pregnancy without multiple births, Stanford researchers find
11. Ingenious Med Forms Multiple Billing Company Partnerships to Market Inpatient Practice Management Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/25/2017)... ... 2017 , ... Order Custom Tee Shirts Online , Welldonedesigns.com ... to be concerned about garment selection, expensive graphic designers, substandard printing, and shipping. ... and shipped within 5-10 days. And every garment we ship is shipped ...
(Date:9/25/2017)... ... September 25, 2017 , ... How many things are on your average ... phrase “more than any sane human could possibly complete,” then you’re all too familiar ... are desperately trying to be everything to everybody all the time. , Self-proclaimed overly ...
(Date:9/25/2017)... Grants Pass, OR (PRWEB) , ... September 25, ... ... good idea. Kleyne, host of the nationally syndicated The Sharon Kleyne Hour Power ... Tears® EyeMist®, would like us to shift our Olympic focus from a once-every-four-years ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... services supporting clinical research, today announces that 30 of its domain experts ... drug development lifecycle at upcoming industry conferences and webinars. Drawing on broad ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... to announce the next generation for LASIK in Manhattan with Contoura Vision, the ... technologically advanced laser systems available in the United States to correct nearsightedness and ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 2017  Robert G. Szewc, M.D., is recognized by ... recognition of his contributions to the Medical field.      ... at the practice of Kidney and Hypertension Specialists, which ... hypertension solutions. He has worked in this position since ... as well as expertise in kidneys, hypertension, chronic disease ...
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
(Date:9/6/2017)... Eli Lilly and Company (NYSE: LLY ) ... and lasmiditan, two investigational treatments for migraine, at the ... place Sept. 7-10 in Vancouver . ... from an open-label study evaluating the safety and effectiveness ... mg) for the prevention of migraine. Galcanezumab is a ...
Breaking Medicine Technology: