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Multifocal/multicentric breast cancer connected to a patient's risk of local recurrence
Date:10/28/2012

BOSTON, MA (October 28, 2012)Not all women diagnosed with operable breast cancer present with a single tumor; some have multifocal disease appear in the breast, which means multiple tumors found in the same breast quadrant, while others have multicentric disease, where multiple tumors are found in separate breast quadrants. Multifocal or multicentric disease is not a standard indication to receive radiation after mastectomy. For patients who undergo lumpectomy, radiation dose and extent is not altered based on multifocal or multicentric disease compared to patients presenting with a single tumor.

Though previous researchers have analyzed data on patients with this type of breast cancer, "there is not a strong consensus on whether or not having multifocal or multicentric breast cancer leads to higher recurrence rates," says Tiffany Tam, MD, an attending physician in the Radiation Oncology Department at Fox Chase Cancer Center, who will present new findings about this on October 30 at the American Society for Radiation Oncology's 54th Annual Meeting.

Tam led a team of Fox Chase physicians in a retrospective study designed to investigate for possible differences in outcomes. They found no statistically significant difference in overall survival or distant recurrence, where the cancer spreads to other organs or tissues. However, local recurrencehaving cancer return to the same area from which it was surgically removedoccurred more than 2.5 times more often among patients with multifocal/multicentric disease, compared to patients with a single tumor.

Tam and her colleagues analyzed the medical records of 112 women who were treated for multifocal or multicentric breast cancer at Fox Chase between 1983 and 2010. They compared outcomes data from those patients with data from 263 women treated for unifocal disease during the same period. Patients from the two groups were matched by age, gender, and stage at diagnosis. The researchers inc
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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

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