Navigation Links
Multifocal lung cancers appear to originate from single cancer clone
Date:4/7/2009

Multiple, anatomically distinct lung cancer tumors may frequently arise from a single cancer cell, according to a retrospective analysis of patient tumor samples published in the April 7 online issue of the Journal of the National Cancer Institute.

Some lung cancer patients have multiple anatomically distinct tumors at the time of diagnosis. Although such multiple tumors usually share a common appearance, it has been unclear whether they arise from a single tumor or are independent primary cancers.

In the current study, Liang Cheng, M.D., of the Indiana University School of Medicine in Indianapolis, and colleagues examined 70 lung cancer tumors from 23 female and seven male patients to determine whether multiple tumors from an individual patient shared a common genetic pattern. The investigators analyzed the tumors for chromosome loss at six loci previously associated with lung cancer and for mutations in the TP53 gene. They also analyzed the X-chromosome inactivation pattern in tumors from female patients.

Based on these three analyses, the investigators concluded that the multiple tumors in 23 of the 30 patients (77 percent) arose from a single cancer clone.

"Our findings support the current classification of multifocal lung cancers as advanced-stage cancersrather than separate primary cancers and the use of therapeutic strategies tailored for patients with advanced-staged cancers," the authors write.

"The results of these studies pose both important biological and clinical management questions," according to Adi F. Gazdar, M.B.B.S., and John D. Minna, M.D., of the University of Texas Southwestern Medical Center in Dallas, who wrote an accompanying editorial. The editorialists review what is known about the biology of multifocal cancers and note that as many as 8 percent of lung cancer patients have multiple anatomically distinct tumors at the time of diagnosis.

An updated lung cancer classification system is expected sometime in 2009 and will distinguish between patients with regional metastatic disease, including those with multiple tumors at diagnosis, and patients with distant metastases. "Clearly, multifocal lung cancers (without distant metastases) constitute a unique set of tumors having heterogeneous origins and better than expected prognosis and should be classified and treated appropriately," the editorialists write.


'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Human papillomavirus genotype distribution in New Mexico cervical cancers
2. Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
3. Genetic changes outside nuclear DNA suspected to trigger more than half of all cancers
4. Early detection of second breast cancers halves womens risk of death
5. Watchful Waiting Safe With Low-Risk Prostate Cancers
6. Freezing Kidney Cancers Shows Promise
7. Bone Cement Eases Pain of Late-Stage Cancers
8. Report: Many Cancers Could Be Prevented in US
9. Landmark Policy Report: Many Cancers Could Be Prevented Across the Globe
10. Landmark Report: Many Cancers Could be Prevented
11. 2 gene mutations linked to most common brain cancers -- and longer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... 2016 , ... In honor of National Physical Fitness and Sports Month in ... their fitness journey on social media. , The foot care company, which specializes ... product voucher each week during May to one winner. , “Whether the goal is ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Over $60 ... year’s best in pet gear and toys, leading product review site for Toys, Tots, ... of Excellence Awards at their Spring Showcase at the Metropolitan Pavilion in New ...
(Date:5/2/2016)... ... May 02, 2016 , ... Further establishing itself as ... that the new WHIMZEES Variety Value Boxes were selected from over 1,000 entrants as ... Award. , WHIMZEES natural dental chews for dogs are a favorite product among ...
(Date:5/2/2016)... CA (PRWEB) , ... May 02, 2016 , ... The 2016 World Ultimate & Guts ... Ultimate Camp at Manhattan College, made the cut. The WUGC is being held in London, ... Teams won the gold in the men’s division, another gold in the women’s masters division, ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Sixth Annual Lifestyle ... the Bellagio Hotel in Las Vegas, NV from October 17–19, 2016. The ... the event. , This year’s conference will offer presentations featuring new treatment ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...  The blood testing market in China ... Information and The Freedonia Group in a recent report.  ... The healthcare research firm said that China ... stations and in improving testing at the provincial level.  ... Blood Testing Market in China , which ...
(Date:4/28/2016)... April 28, 2016 Dr. Vivek ... and Ste phen Schmidt ... a leading provider of cloud-based software solutions for life sciences, today ... to bring a wealth of insight to a growing business.  This ... George Phillips joined ArisGlobal in the position ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
Breaking Medicine Technology: