Navigation Links
Multidisciplinary research team led by Tufts CTSI proposes new model for clinical trials
Date:3/19/2014

BOSTON (March 19, 2014) Experts across academia, industry and government propose a new method for health care providers to get the right treatments to the right patients at the right time. This new approach, A Proposal for Integrated Efficacy-to-Effectiveness (E2E) Clinical Trials, published in Nature Clinical Pharmacology & Therapeutics, recommends a seamless transition from controlled experiments to real-world comparative effectiveness trials. This continuum will improve the accuracy of treatment selection and better determine how those treatments work on different groups of people.

Efficacy trials are conducted in optimal conditions with patients who have similar characteristics. These trials are typically used to secure regulatory approval for a drug.

Effectiveness trials are conducted in more typical clinical settings, with patients who have varying characteristics. These trials are designed to determine whether treatment effects identified in efficacy trials carry over to more typical uses of drugs in practice.

Currently, efficacy and effectiveness trials are conducted separately, and effectiveness trials may occur years later or not at all. In the E2E model, an effectiveness trial starts immediately after the efficacy trial is completed (or as soon as possible, depending upon a predetermined approval process). Data derived from the efficacy trial can be used to formulate questions to investigate during the effectiveness trial; data derived from the effectiveness trial can then be used to assist patients and providers in making individual treatment decisions.

Development of the E2E approach was led by Harry P. Selker, MD, MSPH of Tufts Clinical and Translational Science Institute (CTSI) and Tufts Medical Center's Institute for Clinical Research and Health Policy Studies (ICRHPS), with assistance from Aaron Kirby, MSc, T
'/>"/>

Contact: Amy West
awest@tuftsmedicalcenter.org
617-636-6025
Tufts Clinical and Translational Science Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Multidisciplinary teams helped marathon bombing survivors rebuild their lives
2. Wayne State awards $1.8 million to enhance multidisciplinary research
3. Multidisciplinary initiative reduces airway infection in pediatric intensive care patients
4. Ottawa researchers find new pathway connected to type 2 diabetes
5. Shoulder revision repair surgery not as successful 2 years later, say researchers
6. Researchers find significant increase in painkillers prescribed to US adults in the ER
7. Dartmouth researchers develop new approach to chronic lymphocytic leukemia treatment
8. New stroke research combines brain stimulation, gait training
9. MD Anderson honors 2 champions for women in medicine and research
10. Innovative gaming research gains national recognition
11. Researchers destroy cancer with cryoablation & nanoparticle-encapsulated anticancer drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... LunaDress, with its top dressmaking technologies, has been a ... is showing its latest designs of wedding dresses and launching ... company’s CEO, all the fresh new products are designed for ... to 80% off. All the clothes from LunaDress follow up ...
(Date:1/22/2015)... January 23, 2015 VogueQueen is a seasoned ... prices and many designers are thrilled to have it lead ... announces its new collection of prom dresses for the global ... drive the strategic vision and he focuses on continuing the ...
(Date:1/22/2015)... 22, 2015 The federal court overseeing thousands ... District Court, Southern District of West Virginia has upheld a ... proceeding’s first bellwether trial. In an Order dated January 21st, ... after finding that C.R. Bard had not proven a miscarriage ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
Breaking Medicine News(10 mins):Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Speaker Nancy Pelosi and Democratic leaders held a press availability ... the Cannon Caucus Room. Below are the Speaker,s opening remarks: ... was a great occasion for us to receive the President of ... history with our vote and making progress for the American people. ...
... the U.S. , SATURDAY, Nov. 7 (HealthDay News) -- Nearly ... it,s not sex). , Rather, it,s binge drinking -- downing ... have a hard time identifying alcohol as a drug," said ... counseling center at Stony Brook University on Long Island, N.Y. ...
... ... fights pain and increases circulation with the power of hot peppers and caffeine. ThermaFeet targets ... Vitamin C and Alpha Lipoic Acid. , , ... Schenectady, NY (PRWEB) November 7, 2009 -- A new foot spray from ...
... bill loaded with pledge-breaking tax hikes , WASHINGTON, Nov. 6 ... By formally endorsing the House healthcare bill today, ... campaign was a lie. , During the campaign, Obama made a ... taxes on families making less than $250,000 per year: , ...
... WASHINGTON, Nov. 6 The U.S. Department of Veterans ... capital to signal the beginning of a new mission ... five years. , More than 1,300 VA clinicians and ... providing support for homeless and low-income veterans, and community- ...
... FOREST, Ill., Nov. 6 Hospira, Inc. (NYSE: HSP ... today announced that the company will present at the Piper ... 2009 in New York City. , The presentation is scheduled ... 2, 2009. It will be available to all interested ...
Cached Medicine News:Health News:Pelosi Remarks Following House Democrats' Meeting with President Obama 2Health News:Binge Drinking Puts the Brain, and Life Itself, at Risk 2Health News:Binge Drinking Puts the Brain, and Life Itself, at Risk 3Health News:Hot Peppers and Caffeine Relieve Painful Feet, Toe Fungus and Foot Odor 2Health News:ATR: Obama Lied, His Tax Pledge Died 2Health News:ATR: Obama Lied, His Tax Pledge Died 3Health News:VA Summit Frames Plan to End Veteran Homelessness 2
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ) has ... Market by Product, Application, Technology, End User - Global ... The infectious disease diagnostics market is expected ... million by 2019 from $12,422.8 million in 2014. Increase ...
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition ... & by End User - Global Forecast to 2019" ... diagnostics market is valued at $1,228.58 million in 2014 and ... reach $2,230.72 million by 2019. Allergy diagnostics is used to ...
(Date:1/22/2015)... ( http://www.researchandmarkets.com/research/tl6pqb/xray_detectors ) has announced the addition of ... by FPD Panel Size - Global Forecast to 2019" ... detectors market is a growing field that has witnessed a ... shift from film to filmless imaging. Hospitals and medical imaging ...
Breaking Medicine Technology:Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 2Global X-Ray Detectors (Flat Panel, Computed Radiography, CCD, Line-Scan) Market - Forecast to 2019 3
... closed dilution nebulizer allows the clinician to deliver ... gas into the side port for precise high ... P31000N, for normal flow patients, delivers 8-12 lpm ... the side port. For your high flow needs, ...
... dose inhalers., ,ACE ensures prompt, effective ... Its versatile design allows it to be ... with an endotracheal airway or resuscitation bag ... also be used in conjunction with an ...
Rotary Piston Mini Nebulizer...
Rotary Piston Nebulizer...
Medicine Products: