Navigation Links
Multi-center clinical study intensifies first strike at high-risk cancer in kids
Date:6/12/2012

CINCINNATI An experimental treatment that combines intense chemotherapy with a radioactive isotope linked to synthesized neurotransmitter is being tested in newly diagnosed cases of high-risk neuroblastoma a deadly, hard-to-cure childhood cancer.

The experimental radiopharmaceutical, 131I-MIBG, has already been tested in children with relapsed and resistant neuroblastoma, with encouraging results in reducing tumor size. This has prompted doctors in a new multi-center pilot clinical trial to see if their innovative combination therapy can help improve cure rates for newly diagnosed children and young adults, according to Brian Weiss, MD, trial chair and an oncologist at the Cincinnati Children's Hospital Medical Center.

Cure rates for neuroblastoma have plateaued at about 40 percent and new solutions are needed to improve outcomes, said Weiss, a member of the medical center's Cancer and Blood Diseases Institute.

"Unlike some diseases, there is no single detectable biological sign of neuroblastoma, so it's hard to catch early," he explained. "Children with relapsed disease usually don't survive more than a few years. We want to see if giving this more intensive treatment right after diagnosis will safely decrease the chances of the cancer coming back."

Neuroblastoma is one of the most commonly diagnosed childhood cancers, developing in nerve cells outside the brain. The cancer is usually first diagnosed by showing up as a lump or mass in the belly, or near the spinal cord in the chest or neck. The disease can spread to bone, the liver, lymph nodes and bone marrow. In high-risk neuroblastoma, the tumor has often spread from its primary site and is harder to treat.

MIBG stands for Meta-Iodo-Benzyl-Guanidine, a synthesized form of the adrenal gland hormone and neurotransmitter adrenalin. MIBG concentrates selectively in the body's sympathetic nervous system, which helps control glands and muscles. When attached to the
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Canada should significantly increase its funding of randomized clinical trials
3. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
4. Experts call for clinical trials to test non-skeletal benefits of vitamin D
5. Clinical news alert: Journal of the American Academy of Orthopaedic Surgeons May highlights
6. Automated insulin dosage titration system demonstrates positive clinical study results
7. Analysis Finds Clinical Trials Often Small, of Poor Quality
8. URMC clinical trial tests new regimen for hypertension
9. Association for Psychological Science, SAGE launch Clinical Psychological Science
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Kroenke honored for outstanding contributions in clinical research training
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... May 06, 2015 LINET Americas has ... Charlotte in the small business category. The award was ... International Community Award is given on an annual basis ... exhibit outstanding contributions to philanthropy. Since 1998, the ... have hosted the Mayor’s International Community Awards. The award ...
(Date:5/6/2015)... 2015 The beverage industry has grocery ... Miracles organic tea and superfruit fusions stands out among ... sweetened with agave, these delicious juice blends are making ... healthier ways to hydrate. , In collaboration with National ... to raise a bottle of Lemongrass Tea and Ginseng, ...
(Date:5/5/2015)... The Florida Comprehensive Epilepsy and Seizure ... recognized by the National Association of Epilepsy Centers ... role of a specialized epilepsy center is to ... type and seizure syndrome, comprehensive epilepsy education for ... a patient’s diagnosis and surgical treatment or access ...
(Date:5/5/2015)... May 05, 2015 NCPDP announced today ... Program. The program establishes a three-year commitment of strategic ... of 10 Elite Partners. “AmerisourceBergen has supported our multi-stakeholder ... of NCPDP, “and this is a wonderful continuation and ... We can trace AmerisourceBergen back to our very first ...
(Date:5/5/2015)... 05, 2015 Hiliary Critchley, Senior ... present at the 24th Annual WEDI National ... MT in Scottsdale, AZ. WEDI, the Workgroup for ... authority on the use of health IT to ... National Director of Telemedicine for UnitedHealthcare will co-present ...
Breaking Medicine News(10 mins):Health News:LINET Americas Wins The Mayor's International Community Award in Charlotte 2Health News:Say Cheers to National Beverage Day with Little Miracles 2Health News:Florida Hospital Tampa Epilepsy Program Earns Designation as a Level 4 Epilepsy Center by the National Association of Epilepsy Centers (NAEC) 2Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 2Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 3Health News:Optimity Advisors’ Hiliary Critchley, Telemedicine Expert, to Speak at WEDI Conference May 20th in Scottsdale, AZ 2
... 10 Caliper Life Sciences, Inc. (Nasdaq: ... at the Cowen and Company 29th Annual Health ... on Tuesday, March 17 at 10:15 a.m. ET. ... will be providing an update on the company,s ...
... Report Finds Public Health Programs At Risk During Economic ... and the Robert Wood Johnson Foundation (RWJF) today released ... received less funding from the federal government than Northeastern ... for disease prevention programs, which can amount to millions ...
... Designed to Optimize Treatment of Patients with Coronary ... Abbott ( NYSE: ABT ) today announced ... a next-generation balloon dilatation catheter with high-pressure capability ... coronary artery disease (CAD) during angioplasty procedures. VOYAGER ...
... 10 Johnson & Johnson will participate in the ... Monday, March 16th at the Boston Marriott Copley Place ... President, Finance and Chief Financial Officer, will represent the ... Time). The webcast will be available to investors and ...
... 10 The Kavli Foundation has announced the appointment ... - only the second president since the Foundation was ... Foundation,s President in late April of this year.Dr. Conn ... acclaimed scientist whose research is focused on plasma physics ...
... in the March issue of the Journal of ... transplantation should be used with caution in patients older ... with high rates of mortality after one year in ... the gold-standard treatment for a variety of end-stage lung ...
Cached Medicine News:Health News:Midwestern and Southern States Receive Least Federal Funding for Disease Prevention 2Health News:Midwestern and Southern States Receive Least Federal Funding for Disease Prevention 3Health News:Midwestern and Southern States Receive Least Federal Funding for Disease Prevention 4Health News:Abbott Launches VOYAGER(TM) NC Coronary Balloon Catheter 2Health News:Abbott Launches VOYAGER(TM) NC Coronary Balloon Catheter 3Health News:Abbott Launches VOYAGER(TM) NC Coronary Balloon Catheter 4Health News:Abbott Launches VOYAGER(TM) NC Coronary Balloon Catheter 5Health News:Dr. Robert W. Conn Named President of The Kavli Foundation 2Health News:Dr. Robert W. Conn Named President of The Kavli Foundation 3Health News:Dr. Robert W. Conn Named President of The Kavli Foundation 4Health News:Journal of American College of Surgeons finds lung transplantation should be used in older patients 2
(Date:5/5/2015)... 2015  Trovagene, Inc. (NASDAQ:  TROV), a developer ... results for the three months ended March 31, ... we presented favorable clinical results at ASCO GI, ... our Precision Cancer Monitoring platform,s ability to detect ... lung cancers," said Antonius Schuh, Ph.D., chief executive ...
(Date:5/5/2015)... LAVAL, QC , May 5, 2015 /CNW Telbec/ ... in Laval and known under ... announces today the closing of the transaction previously announced ... of the issued and outstanding  shares of Orthoconcept (2008) ... by issuing 500 000 common shares (TSXV: ERG) to ...
(Date:5/5/2015)... Valley Medical Center, named a Top 100 Hospitals® in the ... to deploy the wireless Leaf Patient Monitoring System in its ... labor and risk of caesarian births. Studies show ... is reduced in mothers who are upright and mobile during ... epidurals and tend to lie in their labor room beds. ...
Breaking Medicine Technology:Trovagene, Inc. Announces First Quarter 2015 Financial Results 2Trovagene, Inc. Announces First Quarter 2015 Financial Results 3Trovagene, Inc. Announces First Quarter 2015 Financial Results 4Trovagene, Inc. Announces First Quarter 2015 Financial Results 5Trovagene, Inc. Announces First Quarter 2015 Financial Results 6Ergoresearch announces closing of the acquisition of 49% of the shares of Orthoconcept (2008) inc. 2Ergoresearch announces closing of the acquisition of 49% of the shares of Orthoconcept (2008) inc. 3Desert Valley Medical Center First to Use Leaf Patient-Wearable Technology to Help Reduce C-Sections, Speed Labor 2Desert Valley Medical Center First to Use Leaf Patient-Wearable Technology to Help Reduce C-Sections, Speed Labor 3Desert Valley Medical Center First to Use Leaf Patient-Wearable Technology to Help Reduce C-Sections, Speed Labor 4
... 11, 2011 Tonight,s "Dan Rather Reports" examines ... of antibiotics. Every year, more than 90,000 Americans ... antibiotic-resistant infections, caused directly by the overuse of ... $35 billion a year.  In tonight,s program, Dan ...
... 2011 WebMD Health Corp. (Nasdaq: WBMD ) ... million aggregate principal amount of 2.50% Convertible Notes due 2018 ... the exercise in full of the initial purchaser,s over-allotment option). ... to Rule 144A under the Securities Act of 1933.   ...
Cached Medicine Technology:Dan Rather Reports Investigates our Heavy Dependence on Antibiotics - What are the Causes... and the Consequences? 2Dan Rather Reports Investigates our Heavy Dependence on Antibiotics - What are the Causes... and the Consequences? 3Dan Rather Reports Investigates our Heavy Dependence on Antibiotics - What are the Causes... and the Consequences? 4WebMD Closes Offering of 2.50% Convertible Notes Due 2018 2
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
... by an independent laboratory to ... Federal Standard 209E. Ergonomic seat ... and back injuries. Clean vinyl ... Static-control chairs feature dissipative vinyl, ...
Inquire...
The model 55D Rocking Shaker provides the same Reliable quality as the 55S, but double the value. The 55D gives you an additional platform with a height of 3.25 in....
Medicine Products: