Navigation Links
Mucous breakthrough in mice holds promise for cystic fibrosis
Date:7/29/2008

A London, Canada scientist studying cystic fibrosis (CF) has successfully corrected the defect which causes the overproduction of intestinal mucous in mice. This discovery by Dr. Richard Rozmahel, a scientist with the Lawson Health Research Institute, affiliated with The University of Western Ontario, has clear implications to understanding and treating this facet of the disease in humans. CF is a fatal, genetic disease characterized by an overproduction of mucous in the lungs and digestive system.

Rozmahel and his colleagues are identifying secondary genes that could contribute to CF, and measuring their impact on the disease. More specifically, they are investigating the potential of a gene found in mice, mCLCA3, which is similar to one in humans that exhibits abnormal levels in CF. The mCLCA3 gene is expressed by cells that produce and secrete mucous.

The researchers discovered that mCLCA3 plays an important role in the property of mucous, thereby allowing it to be cleared rather than result in the blockages that underlie CF. By correcting the abnormal levels of mCLCA3 in CF mice they were able to overcome the mucous lesions. Whereas CF mice normally do not survive more than 4 weeks as a consequence of the mucous disease, the animals where mCLCA3 levels were corrected could live a normal lifespan.

"It's my hope to understand what is causing the exaggerated mucous production and secretion in CF patients," says Dr. Rozmahel. "From there, we can figure out ways to correct it."


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Page: 1

Related medicine news :

1. LegalView Unveils Details of a Breakthrough Mesothelioma Cancer Early Detection Test for Mesothelioma Patients
2. Medelita Introduces A Breakthrough In Healthcare Uniforms For Women
3. Canine Cancer #1 Fear of Dog Lovers; Web Exclusive By Morris Animal Foundation Provides News on Latest Breakthroughs - Crucial Facts for Dog Owners
4. Video: Chatto Skincare Unprecedented Breakthrough
5. Breakthroughs Offer Hope to MS Patients
6. DOT Therapy: Newest Breakthrough Technology in Laser Skin Resurfacing
7. Breakthrough Technology That Will Revolutionize the Treatment of Tooth Decay
8. Breakthrough "Neuro Nutrition" Targets the Brain and Vagus Nerve To Boost the Body's Immune, Hormone and Neurological Systems
9. Breakthrough Coaching is Celebrating the Launch of Breakthrough Coaching TV
10. Solidica Awarded 2008 Best of Sensors Expo Honor for Breakthrough Battery Health Monitor
11. Breakthrough Isolaz(TM) Acne Therapy Featured in U.S. News & World Report:
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2017)... , ... July 21, 2017 , ... Reassured For Life ... brokerage firm servicing Albertans,” says owner and licensed broker Nerissa McNaughton. “I launched this ... be difficult, but it is a very necessary conversation. I make it easy. As ...
(Date:7/22/2017)... (PRWEB) , ... July 22, 2017 , ... ... patients with irreparable rotator cuff repairs the opportunity to return to sports and ... American Orthopaedic Society for Sports Medicine’s Annual Meeting in Toronto, Ontario, ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Bryant ... to families and business owners in the Dalton region, is working in conjunction ... overcoming sexual assault and physical abuse. , The GreenHouse is headquartered in Dalton ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Ellis Agency, an eastern Georgie provider ... in a community wide charity event with the goal of bringing in support for ... woman who lives with epilepsy, recently launched a charity campaign of her own by ...
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... insurance assistance and financial planning services to communities in the greater Birmingham area, ... to provide resources to underprivileged young people in the region. , The Chris ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... , July 21, 2017  Endo International plc ... completing a comprehensive review of its manufacturing network, the ... and distribution facilities in Huntsville, Alabama ... take place over the next 12 to 18 months. ... impacted by declining volumes of commoditized products and these ...
(Date:7/19/2017)... , July 19, 2017  Mako Medical Laboratories ... and the Military Family Assistance Fund (MFA) to bring ... to visit with their families one last time ... to coordinate the travel and logistics needed for these ... deployed soldiers and their families. We just wish we ...
(Date:7/14/2017)... plc (NASDAQ: ENDP ) will announce its second-quarter 2017 ... management team will host a conference call and webcast before the ... The dial-in number to access the call is U.S./ Canada ... 45397076. Please dial in 10 minutes prior to the scheduled start ... the call will be available from August 8, 2017 at 11:30 ...
Breaking Medicine Technology: