Navigation Links
Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
Date:2/15/2008

st cancer.

The idea that SERMs could act like an estrogen in one place and an anti-estrogen in the other has created a new dimension in drug development, Jordan says. Now we can look at the design of these drugs and see how they can be applied to modulate other receptor sites throughout the body.

According to Jordan, recent studies have shown light on the complex and seemingly contradictory mechanisms behind the activity of receptors for steroids, such as estrogen. These mechanisms include slight structural differences in the estrogen receptors themselves in different tissues, as well as co-regulatory molecules that can influence whether a SERM will turn on or shut down a particular receptor. Of the 48 or so members of the nuclear receptor family, which include the molecules inside cells that bind to estrogen and other hormones, nearly half are able to be regulated in some way.

Our knowledge of how tamoxifen and raloxifene work is now being applied to develop new drugs that are selective male hormone receptor modulators that could be used in men to improve muscle weight during sickness, but without stimulating glands like the prostate, Jordan says. Indeed, a whole variety of nuclear steroid hormone receptor mediated drugs are now possible because of the understanding of SERM action.


'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-316-8977
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Congressional Budget Includes Earmark to Keep Washingtons Sexual Assault DNA Program Moving Forward
2. AUDIO from Medialink and GlaxoSmithKline: Get Ready to Get Moving to a New You in the New Year
3. After Dropping 162 Pounds, Jodi Davis Inspires Other Michigan Women to Get Moving and Lose Weight Through WalkyTalk.com(TM)
4. Growth Needs Space: joimax, Inc. USA, is Moving Into New Premises
5. GPS-like technology helps pinpoint best methods for moving injured players
6. Removing Ovaries Before Menopause Leads to Memory, Movement Troubles
7. Legislative and Regulatory Outlook - 2009 and Beyond for Pharma, Biotech Players
8. Michigan Kidney Patient Goes Above and Beyond to Help His Community - Awarded National DPC Hero Award
9. Fourth Annual James E. Marshall OCD Foundation Beyond Beauty Dinner to Honor E. Scott Beattie, Chairman and CEO, Elizabeth Arden, Inc. and Charles H. Townsend, President and CEO, Conde Nast Publications
10. Ashley Forms Partnership With Roger Burgess and ProCare Rx to Carry Gotham Banner into 2008 and Beyond
11. 10 Cities to Participate in Live Well! Life Beyond Cancer Program Sponsored by The Wellness Community and the Lance Armstrong Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... York, NY (PRWEB) March 06, 2015 ... of “Women’s Health,” a campaign that seeks to educate, ... role when it comes to their health and their ... the rise, it has never been more pertinent to ... rights. , The print component of “Women’s Health” ...
(Date:3/6/2015)... March 06, 2015 As healthcare ... images and content from disparate systems, they are ... care and increase efficiency. Enterprise content management ... content with core IT solutions, including electronic medical ... existing IT applications. , The following organizations ...
(Date:3/6/2015)... ” was featured on NewsWatch as part of its monthly ... the iOS, Android, and Windows markets. Mallory Sofastaii, a mobile ... and shared with viewers how this is a fully immersive ... mobile games have benefited from building in a social media ... to connect their games to Facebook, see what level their ...
(Date:3/6/2015)... Saving Moses, a global humanitarian organization ... traveling to Angola, Africa March 7-14 to visit malnutrition ... , This will be the organizations fifth time to ... commitment to the region’s population by saving infants and ... with the mothers and babies of the malnutrition program, ...
(Date:3/6/2015)... 2015 Ticket Down is a reputable source ... at the Moda Center. After being away from the ... showing no signs of letting up on his “Garth Brooks ... his wife, Trisha Yearwood, to venues around the United States. ... critically acclaimed tour to the Moda Center in Portland, OR. ...
Breaking Medicine News(10 mins):Health News:The Well-Woman: Encouraging Regular Screenings and Advocating for Women’s Health Rights with Mediaplanet’s “Women’s Health” Campaign 2Health News:Healthcare Providers Select OnBase by Hyland to Improve Patient Care and Streamline Administrative Departments 2Health News:Healthcare Providers Select OnBase by Hyland to Improve Patient Care and Streamline Administrative Departments 3Health News:A Kawaii Social Game was Featured on NewsWatch Television on February 26, 2015 2Health News:Saving Moses Returns to Angola to Continue Giving Infants and Children a Chance to Live 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 3
... Curative ... Therapy Driving Growth, ARCADIA, Calif., Oct. 3 ... Program for Los Angeles, a,ranking of the 50 fastest growing technology, ... Touche USA LLP, one,of the nation,s leading professional services organizations. Rankings ...
... CHICAGO, Oct. 3 President Bush,s veto today,of ... for millions of,children from families with low incomes ... dental health, says Oral Health America, a national,advocacy ... ten million children eligible for coverage through a,bipartisan, ...
... Citys infant mortality rate widely regarded as a barometer ... the Health Department reported today. The rate in 2006 was ... the previous year. The City has made major progress in ... was double what it is today, but the decline has ...
... faculty has received a five-year, $8.4 million grant from ... to survey the genetic, physical and behavioral profiles of ... the reach and ethnic diversity of the Autism Genetic ... research, overseen by Clara Lajonchere, research assistant professor at ...
... WASHINGTON, Oct. 3 The United States,Conference of ... H.,Palmer, today expressed shock and disbelief at President Bush,s ... Insurance Program known as,SCHIP. With his action, 10 million ... protection., "We are extremely disappointed because this is ...
... The California Nurses,Association/National Nurses Organizing Committee today condemned ... Children,s Health Insurance,Program. "Listening to the overheated rhetoric ... Rove may be gone but his legacy lives on," ... Presidents. She chastised,Bush for his recent claims that legislators ...
Cached Medicine News:Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 2Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 3Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 4Health News:SCHIP Veto a Big Cavity for Children's Oral Healthcare, Advocates Say 2Health News:New York City's infant mortality rate declined in 2006 2Health News:New York City's infant mortality rate declined in 2006 3Health News:New York City's infant mortality rate declined in 2006 4Health News:USC granted $8.4 million for autism research 2Health News:USC granted $8.4 million for autism research 3Health News:Mayors Express Frustration Over President Bush's Veto to SCHIP Legislation 2Health News:California Nurses Association Blasts Bush for Veto on Children's Health 2
(Date:3/6/2015)...  Aethlon Medical, Inc. (OTCQB:AEMD), the pioneer in developing ... today announced that James A. Joyce , Aethlon ... overview at the 27th Annual ROTH Conference on March ... previously scheduled to present at 5:30 pm Pacific on ... at The Ritz-Carlton Hotel in Laguna Niguel, ...
(Date:3/6/2015)... , March 6, 2015  Par Pharmaceutical ... a conference call on Friday, March 13, 2015 ... of operations for the fourth quarter and full ... held and currently makes certain financial information available ... Securities and Exchange Commission and will make certain ...
(Date:3/6/2015)... -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) announced ... payment from Biogen Idec related to advancing the ongoing ... infants with spinal muscular atrophy (SMA).  ... is a randomized, double-blind, sham-procedure controlled thirteen month study ... will evaluate the efficacy and safety of a 12 ...
Breaking Medicine Technology:Update - Changed Time for Aethlon Medical Presentation at the 27th Annual ROTH Conference 2Isis Pharmaceuticals Earns $9M for Advancing ISIS-SMN Rx in Infants With Spinal Muscular Atrophy 2Isis Pharmaceuticals Earns $9M for Advancing ISIS-SMN Rx in Infants With Spinal Muscular Atrophy 3Isis Pharmaceuticals Earns $9M for Advancing ISIS-SMN Rx in Infants With Spinal Muscular Atrophy 4Isis Pharmaceuticals Earns $9M for Advancing ISIS-SMN Rx in Infants With Spinal Muscular Atrophy 5
... PARSIPPANY, N.J., Jan. 11 Survival of the fittest? ... not only what you know today, but what you need ... Whoever has the right insight and accurate forecasting skills will ... (and growing) market in the world, its sheer size also ...
... Calif., Jan. 11 Derycz Scientific (OTC Bulletin Board: DYSC), a ... of information from content publishers to enterprise customers and their constituents, ... the website of DDN ( Drug Discovery News ). ... is titled "Speeding the Path to FDA Approval in the Era ...
Cached Medicine Technology:Elite Pharma Insiders to Reveal Key Survival Strategies for Pharmaceutical Industry in 2010 2Derycz Scientific Featured In DDN (Drug Discovery News) 2Derycz Scientific Featured In DDN (Drug Discovery News) 3
... Safely And Easily Cut Foldable Silicone ... To Cut And Remove Even High ... One Instrument.,New Miniaturized Profile Allows Insertion ... Explantation Of A Silicone Lens.,Available For ...
... The Gauges Are Available As One Unit, ... To Test The Width Of A Phaco Incision. ... And Increase In Width Up To ... Use, And Provide Accurate Information As To The ...
... Designed To Rest Either Nasally Or ... Over, Allowing Eyelids To Be Opened ... Widest Possible Aperture.,Open And Close With ... To The Globe During Clear Corneal ...
... To Dial An Exact Extension Of The ... Visibility, With Titanium Handle & Spring. ,Unique ... Tissue, And Can Also Be Dialed To ... Made In The USA, Handle Guaranteed For ...
Medicine Products: