Navigation Links
Moving 3D computer model of key human protein is powerful new tool in fight against cancer
Date:6/19/2012

A picture is worth 1,000 words when it comes to understanding how things work, but 3D moving pictures are even better. That's especially true for scientists trying to stop cancer by better understanding the proteins that make some chemotherapies unsuccessful.

Researchers for decades have had to rely at best on static images of the key proteins related to recurring cancers.

Now SMU biochemist John G. Wise at Southern Methodist University, Dallas, has brought to life in a moving 3D computer model the structure of human P-glycoprotein, which is thought to contribute to the failure of chemotherapy in many recurring cancers.

"This is a very different approach than has been used historically in the field of protein structure biochemistry," Wise said. "Historically, proteins are very often viewed as static images, even though we know that in reality these proteins move and are dynamic."

The model is a powerful new discovery tool, says Wise, particularly when combined with high-performance supercomputing. The dynamic 3D model already has made it possible for Wise to virtually screen more than 8 million potential drug compounds in the quest to find one that will help stop chemotherapy failure. http://bit.ly/MeUFOo

So far, the supercomputer search has turned up a few hundred drugs that show promise, and Wise and SMU biochemist Pia Vogel have begun testing some of those compounds in their wet lab at SMU.

"This has been a good proof-of-principle," said Wise, a research associate professor in the SMU Department of Biological Sciences. "We've seen that running the compounds through the computational model is an effective way to rapidly and economically screen massive numbers of compounds to find a small number that can then be tested in the wet lab."

Wise describes his research findings in Biochemistry in the article "Catalytic Transitions in the Human M
'/>"/>

Contact: Margaret Allen
mallen@smu.edu
214-768-7664
Southern Methodist University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. New surgical technique for removing inoperable tumors of the abdomen
2. Exercise Plus Computer Time May Boost Seniors Brains
3. Researchers develop a new cell and animal model of inflammatory breast cancer
4. Model for breast cancer rehab featured in supplement to ACS journal, Cancer
5. Research shows efficacy of treatment model developed at Women & Infants
6. HHS enlists Archimedes Inc. to expand governments use of health care modeling
7. Modeling the demise of migrating brain tumor cells
8. Super Models Line Up to Walk The Catwalk and Celebrate Vogue's Fashion Night Out in LA
9. Nerve growth factors elevated in pancreatic cancer model
10. New drug prevents spread of human prostate cancer cells
11. Scientists solving the mystery of human consciousness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Moving 3D computer model of key human protein is powerful new tool in fight against cancer
(Date:7/13/2014)... New York (PRWEB) July 13, 2014 ... bring attention to the cancer risks associated with power ... to tell their story to federal regulators, as they ... U.S. Food & Drug Administration (FDA) advisory panel ... reports. According to the Rochester Democrat and Chronicle, ...
(Date:7/13/2014)... July 13, 2014 Recently, 2014QuinceaneraDresses.com, ... has unveiled its new range of gorgeous ... market, the demand for elegant Quinceanera outfits is ... beautiful items. All the company’s newly released dresses ... They are all elegant and vivid. , ...
(Date:7/13/2014)... ANGELES A noninvasive optical imaging device developed ... that later occur in the brain and are ... preliminary results from investigators conducting a clinical trial ... findings July 15 in an oral presentation at ... Denmark. They also were invited by conference organizers ...
(Date:7/13/2014)... California (PRWEB) July 13, 2014 Celebrity ... Musico has formed a promotional partnership with Aqua Health ... based Omega-3 EPA supplement . The collaboration was ... a celebrity fitness trainer , actor, model, and ... go-to trainer for A-List celebrities, he has prepared stars ...
(Date:7/13/2014)... July 13, 2014 According to the ... this is a comprehensive guide that features a series ... with KP (keratosis pilaris). This guide consists of ... Is Keratosis Pilaris? ,     Chapter 2: What Cause ... If I Have KP? ,     Chapter 4: Keratosis ...
Breaking Medicine News(10 mins):Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 2Health News:Living With KP Book Review Exposes Jennifer Richards' Keratosis Pilaris Guide – Vkool.com 3
... WASHINGTON, March 28 Thousands of epilepsy advocates, caregivers, ... celebrities at the nation,s Capitol today to support the ... two years, the event has raised more than $2 ... event is expected to increase those numbers significantly. Money ...
... could replace anti-clotting drug warfarin for many patients, researchers ... implanted device may soon replace the anti-clotting drug warfarin ... with atrial fibrillation, a new study suggests. , People ... stroke, the researchers noted, and typically need to take ...
... in era of rising costs , , FRIDAY, March 27 (HealthDay ... national health care reform when she was first lady in ... are working -- are without health insurance. , That finding ... a state-by-state picture of people foregoing insurance because of rising ...
... Drug-eluting stents were safe and superior to bare metal ... "real-world" patients enrolled in a nationwide registry of cardiovascular ... , The findings were presented today at the ... Scientific Session. They also appear online in the ...
... (NYSE: NUS ) announced that more than 100,000 ... the company,s distributors and customers who have purchased Epoch Baobab ... company has donated $0.25 from the sale of every Epoch ... Foundation,s Seeds of Hope reforestation project. "When someone purchases a ...
... Earnings Guidance to a Minimum of $0.25 per diluted ... Service Corporation (Nasdaq: PRSC ) today announced ... December 31, 2008. Included in the results is ... related to the Company,s intangible assets, which, when added ...
Cached Medicine News:Health News:Video: Celebrities and Thousands of Walkers Unite at Nation's Capitol to Raise Awareness About Seizures and Epilepsy 2Health News:Video: Celebrities and Thousands of Walkers Unite at Nation's Capitol to Raise Awareness About Seizures and Epilepsy 3Health News:New Device Treats Common Heart Rhythm Disorder 2Health News:New Device Treats Common Heart Rhythm Disorder 3Health News:One in Five Working Adults Said to Lack Health Insurance 2Health News:Drug-eluting stents found safe, superior to bare metal stents 2Health News:Nu Skin Charitable Promotion Reaches Important Milestone: 100,000 Trees Donated to African Nation of Malawi 2Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 2Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 3Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 4Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 5Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 6Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 7Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 8Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 9Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 10Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 11Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 12Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 13Health News:Providence Service Corporation Releases Fourth Quarter and Audited Year End 2008 Results 14
(Date:7/10/2014)... , July 10, 2014  Valeant Pharmaceuticals International, ... today announced it has completed the sale to Galderma ... Dysport owned or held by Valeant for $1.4 billion ... Nestle S.A, which recently completed its acquisition of Galderma. ... divestiture of our products to a company that is ...
(Date:7/10/2014)... July 10, 2014 CVS Caremark Corporation (NYSE: ... has approved a quarterly dividend of $0.275 (27.5 cents) per ... on August 1, 2014, to holders of record on July ... CVS Caremark is dedicated to helping people on their path ... the United States . Through the company,s ...
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3
... 26, 2011 Vapotherm announced today the launch ... specifically for homecare and other low acuity environments. ... and European markets. Vapotherm,s Flowrest® ... home and other extended care environments.  According to ...
... 26, 2011 Omnicell, Inc . (NASDAQ: ... medication and supply management solutions and analytics software ... Victoria Hospital (RVH) selected Omnicell G4 solutions ... by Omnicell,s hallmark flexibility and functionality, RVH became ...
Cached Medicine Technology:Vapotherm Announces Commercial Launch of Flowrest® Homecare Device 2Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 2Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 3Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 4
... Maximum Xtra, and Maximum ACT introducers ... and specialty hemostasis introducers in the ... premier hemostasis introducers for use in ... angiography, angioplasty, stenting, atherectomy, temporary pacing, ...
St. Jude Medical's line of guiding introducers includes Swartz Series, SAFL, SEPT, CSTA, RAMP, and 2 piece steerable...
The intended use of the percutaneous PREFACE Guiding Sheath is for the introduction of intravascular electrophysiology catheters into any cardiac chamber....
... EP Systems sells the popular transeptal ... needles. These products allow left atrial ... catheter ablation of left-sided arrhythmogenic substrates. ... others use it when a transaortic ...
Medicine Products: