Navigation Links
Mouth may tell the tale of lung damage caused by smoking
Date:4/13/2008

>

Strong correlations were observed between methylation patterns in both tissues. When methylation of either gene was considered positive, 37 of the 39 individuals (95 percent) with p16 and/or FHIT promoter methylation in the oral samples had promoter methylation in at least one matched bronchial sample. This compared with only 59 of the 86 (69 percent) individuals without the promoter methylation in the oral samples. Similar correlations were seen at the three-month analysis.

"Our study provides the first systematic evidence that accessible tissue, the oral epithelium, can be used to monitor molecular events in less accessible tissue," Bhutani said. "This provides a convenient biomonitoring method to provide insight into the molecular events that take place in the lungs of chronic smokers."

One follow-up area of study is to find additional biomarkers in oral tissue. "We hope that our findings encourage researchers to test an increasing compendium of biomarkers to confirm the reliability of oral epithelium not only in lung cancer chemoprevention but also in therapeutic settings" said Ashutosh Kumar Pathak, M.D., another key study author and a post-doctoral fellow in Surgical Oncology.

"Our study opens the door to enhancing our ability to predict who has higher probability of getting tobacco-related cancers," Mao said. "Not only lung cancer, but pancreatic, bladder and head-and-neck cancers, which also are associated with tobacco use."


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Monmouth Medical Center Performs New Incisionless Procedure to Treat Weight Regain After Gastric Bypass
2. Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas
3. Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy
4. K-State Researchers Predict That an Outbreak of Foot-And-Mouth Disease Could Cost Kansas Nearly a Billion Dollars
5. Rural patients colon and lung cancers diagnosed earlier, Dartmouth research says
6. AUDIO from Medialink and P&G: New Tools for Promoting Good Mouth Health
7. Audio from Medialink and Philips: Americas Dirty Mouths
8. Healthy Weight Loss Begins With What You Permit to Enter Your Mind, More So Than Even Your Mouth!
9. Mouthpiece Could Help Ease Snoring
10. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
11. New Drug Protects Against Radiation Damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouth may tell the tale of lung damage caused by smoking
(Date:6/2/2015)... 02, 2015 For those that have ... exposed to harmful germs, chemicals and bodily fluids from ... to an inventor from Queens Village, N.Y., their worries ... an efficient, fun, hygienic way to store and dispense ... to bugs, chemicals and germs. Furthermore, it insures that ...
(Date:6/2/2015)... CRN International has been named a 2015 Company Partner ... Connecticut state program that takes active steps to train, coach ... companies. , Platform to Employment is being delivered by ... Labor. CRN, a 40-year-old radio marketing company near New Haven, ... for its “hard work and dedication.” , CRN recently took ...
(Date:6/2/2015)... 02, 2015 The health care leaders ... pioneering provider of value-based care will now offer health ... and Sullivan Counties. The newly launched Crystal Run Health ... commercial Small Group Preferred Provider Organization (PPO) and Exclusive ... Healthcare’s Managing Partner and CEO, Hal Teitelbaum, MD, ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Vancouver, ... by iData Research ( http://www.idataresearch.com ), the bone ... demineralized bone matrices (DBM) over traditional allograft materials. ... incisions and thus an increase in operation time, ... strong market growth in these synthetic materials is ...
(Date:6/2/2015)... 02, 2015 Relias Learning ... solutions for the healthcare market, is partnering with ... offer 10 complimentary courses relating to mental health ... professionals with additional resources to better understand and ... often the first responders to situations involving people ...
Breaking Medicine News(10 mins):Health News:Dental Storage and Dispensing Unit Invented by InventHelp Client (LGI-1890) 2Health News:CRN Named Company Partner of the Year by CT Employment Program 2Health News:Leading Health Care Innovator Poised to Deliver New Health Coverage Options To The Hudson Valley Region 2Health News:Leading Health Care Innovator Poised to Deliver New Health Coverage Options To The Hudson Valley Region 3Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 2Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 3Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 2Health News:Relias Learning Partners with Behavioral Health and Developmental Disabilities Leaders to Offer Complimentary Resources to Public Safety Professionals 3
... of HIV infection than non-smokers, reveals an analysis ... the journal Sexually Transmitted// Infections. ,Cigarette ... than normal chance of contracting other infections generally, ... ,The researchers trawled through 13 academic research ...
... American Dental Association (ADA) reported that serious damage of oral ... This drug harms the ability of chewing.// ,The ... over 12 million Americans have used methamphetamine, also called meth, ... or smoked. Most of the users are of the age ...
... and Hezbollah in Lebanon made a normally tense situation ... Emanuel Hanski, HHMI// international research scholars from Israel, have ... lab to join the military, not knowing when or ... tanks to check up on their research," says Michaeli. ...
... of Medicine researchers have found high rates of hunger ... western North Carolina,// southwestern Virginia and Forsyth County. ... of hunger, there are segments of the N.C. population ... areas of persistent poverty like Appalachia,” said Sara A. ...
... study has indicated that the Human papillomavirus (HPV) could ... Human papillomavirus is// associated with the growth of warts, ... ,Researchers from New York Hospital-Cornell Medical ... had only a 50% chance of conception through the ...
... here Monday in his bid to complete 24 such runs in ... cancer// research. ,"The 'Great World Run' is my greatest ... run 314.4 miles between Sep 7 and Oct 1, and travel ... final run will be at Newcastle upon Tyne in Britain Oct ...
Cached Medicine News:Health News:Methamphetamine causes severe oral health damage 2Health News:Surveys Find Outright Hunger among Latino Immigrants in North Carolina 2Health News:Surveys Find Outright Hunger among Latino Immigrants in North Carolina 3
(Date:6/2/2015)... -- Stoltenberg Consulting , a leading healthcare ... celebration of its 20-year anniversary and over 250 ... inception in 1995. "As the ... technology industry continues, we strive to combine experienced ... clients, organizational goals, understanding that today,s healthcare providers ...
(Date:6/2/2015)... , June 2, 2015 ANI Pharmaceuticals, ... it has received approval from the U.S. Food and ... (ANDA) for Oxycodone Hydrochloride Oral Solution 5mg/5mL. Trailing twelve-month ... IMS, with three current competitors. ANI expects to begin ... S. Przybyl , President and CEO of ANI Pharmaceuticals, ...
(Date:6/2/2015)... June 2, 2015  ErgoNurse, the leader in bedside safety ... products in the United States , have ... long-term care and skilled nursing markets. ... Thousands of ... fully take advantage of the ErgoNurse products to stop unnecessarily ...
Breaking Medicine Technology:Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 2Stoltenberg Consulting celebrates 20 years of healthcare IT consulting service 3ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 2ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 3ErgoNurse and Briggs Healthcare Positioned to Completely Eliminate the Unnecessary Cost of Healthcare-Related Back Injuries 2
... , NEW YORK , Jan. 25 ... of Kinray announced today a substantial donation to charitable organizations ... the largest privately-held distributor of pharmaceutical, generic, health & beauty ... is listed as #183 according to 2009 Forbes Magazine. , ...
... , PLEASANTON, Calif. ... a world leader in device-based mechanical circulatory support therapies to save, support ... results for the 2009 fiscal year on Thursday, January 28 . ... results and operating activities open to all interested parties at 1:30 ...
Cached Medicine Technology:Pharma Billionaire Stewart Rahr Provides Substantial Donation to Haiti Charities 2Thoratec Schedules Fiscal 2009 Year-End Conference Call, Webcast 2
... are packaged in single-use foil-laminated ... is saturated with precisely the ... package is terminally sterilized, ensuring ... the patient. Swabstick provides excellent ...
... All Povidone Iodine 'Prep' ... skin and mucous membrane ... procedures. All Povidone Iodine ... solutions with surfactants. Each ...
... BETADINE Solution ... of 10% povidone-iodine. It ... antiseptic that kills gram-positive ... antibiotic resistant organisms), as ...
... This multi-purpose topical gel contains 10% Povidone ... germicidal action. As a pre-operative prep, Povidone ... of prepping solutions under the patient, thus ... Gel is also approved as a one ...
Medicine Products: