Navigation Links
Mouth may tell the tale of lung damage caused by smoking
Date:4/13/2008

SAN DIEGO - Cells lining the mouth reflect the molecular damage that smoking does to the lining of the lungs, researchers at The University of Texas M. D. Anderson Cancer Center report today at the annual meeting of the American Association for Cancer Research.

Examining oral tissue lining the mouth to gauge cancer-inducing molecular alterations in the lungs could spare patients and those at risk of lung cancer from more invasive, uncomfortable procedures used now, said senior researcher Li Mao, M.D., professor in M. D. Anderson's Department of Thoracic/Head and Neck Medical Oncology.

"We are talking about just a brushing inside of the cheek to get the same information we would from lung brushings obtained through bronchoscopy," said study presenter and first author Manisha Bhutani, M.D., a post-doctoral fellow in Thoracic/Head and Neck Medical Oncology.

The team examined the oral and lung lining tissue - called the epithelium - in 125 chronic smokers enrolled in a large, prospective lung cancer chemoprevention study.

The status of two crucial tumor-suppressing genes was analyzed. The genes, p16 and FHIT, are known to be damaged or silenced very early in the process of cancer development. "There is substantial damage long before there is cancer," Mao said.

Study participants gave both an oral and lung sample initially and then another at three months. The researchers tracked whether either p16, FHIT or both had been silenced by methylation - the attachment of a chemical methyl group to crucial spots in a gene that shut down its function. Patterns of methylation were compared between the tissues.

The baseline tissue comparison showed methylation of p16 in the lungs of 23 percent of study participants, of FHIT in 17 percent and of either of the two genes in 35 percent. The percentages were similar in oral tissue, with p16 methylated in 19 percent, FHIT in 15 percent and one of the two in 31 percent.

Strong correlations were observed between methylation patterns in both tissues. When methylation of either gene was considered positive, 37 of the 39 individuals (95 percent) with p16 and/or FHIT promoter methylation in the oral samples had promoter methylation in at least one matched bronchial sample. This compared with only 59 of the 86 (69 percent) individuals without the promoter methylation in the oral samples. Similar correlations were seen at the three-month analysis.

"Our study provides the first systematic evidence that accessible tissue, the oral epithelium, can be used to monitor molecular events in less accessible tissue," Bhutani said. "This provides a convenient biomonitoring method to provide insight into the molecular events that take place in the lungs of chronic smokers."

One follow-up area of study is to find additional biomarkers in oral tissue. "We hope that our findings encourage researchers to test an increasing compendium of biomarkers to confirm the reliability of oral epithelium not only in lung cancer chemoprevention but also in therapeutic settings" said Ashutosh Kumar Pathak, M.D., another key study author and a post-doctoral fellow in Surgical Oncology.

"Our study opens the door to enhancing our ability to predict who has higher probability of getting tobacco-related cancers," Mao said. "Not only lung cancer, but pancreatic, bladder and head-and-neck cancers, which also are associated with tobacco use."


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Monmouth Medical Center Performs New Incisionless Procedure to Treat Weight Regain After Gastric Bypass
2. Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas
3. Watch Your Mouth: Michigan Association of Endodontists Offers Four Part Series on Keeping Your Teeth Healthy
4. K-State Researchers Predict That an Outbreak of Foot-And-Mouth Disease Could Cost Kansas Nearly a Billion Dollars
5. Rural patients colon and lung cancers diagnosed earlier, Dartmouth research says
6. AUDIO from Medialink and P&G: New Tools for Promoting Good Mouth Health
7. Audio from Medialink and Philips: Americas Dirty Mouths
8. Healthy Weight Loss Begins With What You Permit to Enter Your Mind, More So Than Even Your Mouth!
9. Mouthpiece Could Help Ease Snoring
10. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
11. New Drug Protects Against Radiation Damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouth may tell the tale of lung damage caused by smoking
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Logically, spring ... other seasons, when the weather is too cold, dry or hot, water on the ... can actually absorb moisture from the surrounding air. There’s only one problem, according to ...
(Date:5/6/2016)... ... 2016 , ... From the Speaker Podium to the Exhibit Floor at Booth#514, ... on managing Customers Engagement at SpeechTek 2016 Event, taking place May 23-25 at the ... Presentation on “5 Customer Engagement Strategies to improve Customer Satisfaction in your ...
(Date:5/6/2016)... ... May 06, 2016 , ... ... Sleepopolis.com . , Since launching in September, 2014 Sleepopolis has resided at ... which now include pillows, sheets, mattress toppers, bed frames, and more. , Founder ...
(Date:5/6/2016)... , ... May 06, 2016 , ... ... arrival of Sovaldi, which made headlines mostly for its cost despite its potential ... and moral questions surrounding the drug—part of a class called direct-acting antivirals (DAAs)—have ...
(Date:5/6/2016)... ... May 06, 2016 , ... Kenneth Cochran, ... of Cardiovascular Institute of the South announced today that Dr. Robert Menuet, Interventional ... of an Intravascular Ultrasound Guided Coronary Atherectomy. , This procedure involves ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... -- , First quarter 2016 adjusted diluted ... million , First quarter reported diluted (GAAP) ... , Company revises 2016 financial guidance; now expects 2016 ... 2016 adjusted diluted non-GAAP earnings per share to range from ... regarding Generics business and manufacturing facility restructuring , ...
(Date:5/5/2016)... , May 5, 2016 Research and ... Imaging in Top 5 EU Markets"  report to their offering.  ... report provides information on the current Positron Emission Tomography (PET) ... Markets (T5 EU), which includes France , ... Spain and the United ...
(Date:5/5/2016)... 2016 Research and ... Systemic Lupus Erythematosus Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Systemic Lupus Erythematosus Market and Competitive Landscape ... Systemic Lupus Erythematosus pipeline products, Systemic Lupus ...
Breaking Medicine Technology: