Navigation Links
Mouse study offers new clues to cognitive decline
Date:5/8/2014

12 months," Stein said. "And at the higher dose, we saw a rescue of the neural stem cell pool in aged mice."

Imai called this finding exciting because it supports the possibility of a future NMN supplement.

"We think that NMN could convey a similar effect in people," Imai said. "A future clinical trial for NMN will tell us if it has any efficacy in humans."

In addition to maintaining stem cell populations and keeping the brain supplied with all its cell types, the investigators showed that NAD also is vital for the process of cognition itself.

Reporting in The Journal of Neuroscience, they showed that neurons of the mouse forebrain depend heavily on NAD in normal cognitive function. Instead of deleting Nampt in stem cells, this time Stein deleted it only in neurons of the forebrain. All other cells were normal, including those that make axon insulation.

Without Nampt and its eventual product, NAD, in forebrain neurons, the behavior of the mice changed dramatically, according to the investigators.

"The mice were really hyperactive, with a twofold increase in activity levels," Stein said. "They also showed a loss of anxiety-like behaviors. These mice didn't seem to sense or fear potentially threatening situations and showed fairly drastic memory defects."

Stein pointed out that these neurons are in a region of the brain known to be particularly vulnerable to neurodegenerative conditions from Alzheimer's disease to stroke.

"It's possible that these neurons' dependence on Nampt is responsible for their extreme susceptibility to these conditions," she said. "It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory."

"We haven't done that study yet," Imai added. "But this is the direction the entire field is going."


'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. A novel transgenic mouse model of Chinese Charcot-Marie-Tooth disease type 2L
2. A versatile mouse that can teach us about many diseases and drugs
3. Building a better mouse model to understand pancreatic cancer
4. Researchers identify fundamental differences between human cancers and genetically engineered mouse models of cancer
5. Heated Mouse: Introducing ValueRays® Executive Series Heated Computer Mice
6. Knockout mouse grows larger, but weaker, muscles
7. UCLA and Chinese scientists analyze genetic makeup of human and mouse embryos in amazing detail
8. New mouse model reveals a mystery of Duchenne muscular dystrophy, Stanford scientists say
9. Got an Itch? Mouse Study May Help Explain Why
10. New mouse model confirms how type 2 diabetes develops
11. Transparent Mouse Brain Could Shed Light on Human Brain Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse study offers new clues to cognitive decline
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... One of the most recent dietary trends ... diet. Originally meant for sufferers of gluten intolerance and celiac ... who are looking to get healthier by simply consuming foods ... kind of information erroneous, it also exposes those same consumers ... a drastic change in their food consumption habits. ...
(Date:8/30/2014)... The new review published by Daily Gossip ... Karen Brimeyer, who wanted to make her guide accessible to ... is now easy to find in the form of an ... the author of the new method shares all her tips ... writes in its review that the leaky gut syndrome can ...
(Date:8/30/2014)... August 28th, 2014: With the ... society and the toll that takes on the individual ... continuing education for physical therapists addresses this problem. , ... help others, Hands-On Seminars is offering discounts on their ... learning styles are available to fit the individual needs ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Ms. Meriwether’s striking ... She certainly has an impressive resume to boost. ... USA in 2012. However, she’s also a two time ... student. Nana trained for the 2008 Olympics and played ... USA website, “This six-foot beauty from Potomac, Maryland is a ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2Health News:Leader in Manual Therapy Continuing Education Makes it Easier for Physical Therapists to Improve Results on Patients 2Health News:NJ Top Dentists Announces Cover Model for the Healthy Living: Top Dentists Issue 2
... , MOUNTAIN VIEW, Calif., Sept. 17 ... of kidney dialysis services and a major sponsor of nephrology ... Foundation,s "Pathway to a Cure" walk event in California,s capital ... 2009 at The Capital Building, 1315 10th Street, Sacramento, CA. ...
... EDGEWATER, Md., Sept. 17 The dialogue ... company sees the issue from a totally different perspective. ... technological readiness to implement healthcare changes. , , ... released "Healthcare: State-of-Readiness for HITECH and EHR (Electronic Health ...
... , , DALLAS, ... families and eyesight, as many schools require eye exams and teachers ... new school year, it,s also a chance for families to kick ... day green habits. With this in mind, today Essilor announced the ...
... - (OTCBB: GVBP.OB) - GENova Biotherapeutics Inc. ("GENova"), ... that disrupt the advance of life-threatening cancers, today ... Beckpharma Ltd. ("Beckpharma") -a pharmaceutical development company also ... are joining forces in their mutual mission to ...
... ... is to manage their own health and fitness. The incredible growth of Max Muscle ... for the safe, natural, and scientifically-backed and proven products that Max Muscle Sports Nutrition has ... ...
... ... Alopecia treatment, the "Invisible" hair system. Produced individually for those with medically caused hair ... touch and can be worn long-term. , ... London, UK (PRWEB) September 17, 2009 -- London-based White Cliffs ...
Cached Medicine News:Health News:Satellite Healthcare Helps Support the Cure for Kidney Disease in Sacramento 2Health News:National Survey Reveals Healthcare Providers' Technological Readiness to Participate in Electronic Health Records Network 2Health News:National Survey Reveals Healthcare Providers' Technological Readiness to Participate in Electronic Health Records Network 3Health News:Back to School Season is Time for New Green Routines 2Health News:Back to School Season is Time for New Green Routines 3Health News:GENova Biotherapeutics secures new cancer drugs targets 2Health News:GENova Biotherapeutics secures new cancer drugs targets 3Health News:Max Muscle Franchising Is Fueled By The Passion Behind The Brand 2Health News:Max Muscle Franchising Is Fueled By The Passion Behind The Brand 3Health News:Advanced Alopecia Treatment developed by London-based Hair Replacement Provider 2Health News:Advanced Alopecia Treatment developed by London-based Hair Replacement Provider 3
(Date:8/29/2014)... August 29, 2014 According ... Market by Extraction type (SFE, Cold Pressed, Organic ... Care, Pharmaceutical, Food Supplements, Fragrance, & Others) - Global ... defines and segments the Amaranth Seed Oil Market ... size in terms of value. The Amaranth Seed ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... Research and Development Trend Forecast of Pharmaceutical Equipment ... analyzes China,s pharmaceutical equipment industry ... demand, competition landscape, and business performance of domestic major ...
(Date:8/29/2014)... Corporation , a neurodiagnostics medical device company based in ... Forcht Dagi , MD, DmedSc, MPH, MBA, FACS, FRCSEd  was ... " Teo Forcht Dagi is an experienced leader with ... said Remis Bistras , President and CEO of Vittamed. ... entrepreneurial expertise to our Board." Dr. Dagi is ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2
...  In a move aimed at bolstering current systems for assessing ... created a new method that combines multiple forms of widely ... which rely on detecting evidence of drug safety issues as ... may be able to identify issues years in advance. ...
... Systems, Inc. (NASDAQ: DCTH ) appointed Gregory ... "As a widely respected hepatologist and 2011 ... Gores will contribute a wealth of clinical knowledge on ... Advisory Board," said Eamonn P. Hobbs, CEO & President ...
Cached Medicine Technology:Taking a Predictive Approach to Identifying Adverse Drug Reactions 2Taking a Predictive Approach to Identifying Adverse Drug Reactions 3Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 2Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 3Delcath Appoints Gregory Gores, M.D. to Medical Advisory Board 4
MultiWash Advantage is a versatile microplate washer engineered for reliability. It is designed for lab environments to help streamline their daily processes....
Synchron Hemoglobin A1c (HbA1c) utilizes two unique cartridges, Hb and A1c, to determine HbA1c concentration as a percentage of total hemoglobin....
... Monoclonal antibody method for HbA1c provides outstanding ... 99% agreement with the HPLC method(1) , ... a CV of 2.6%* means your results ... (NGSP) certified method, as recommended by the ...
The sole coagulation analyzer in the world that uses a unique dry reagent card....
Medicine Products: