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Mouse study: Real-time imaging device may improve surgery for congenital colon disease
Date:2/29/2008

LOS ANGELES (Feb. 29, 2008) Researchers at Cedars-Sinai Medical Center are developing a spectral imaging system that could result in shorter operating times for infants undergoing surgery for Hirschsprungs disease, according to a mouse study reported in the Journal of Biophotonics.

The study documents that in addition to its diagnostic potential, spectral imaging may provide an optical biopsy, allowing precise localization of a needed intervention.

Spectral imaging is based on the fact that light reflected from a target can be captured and measured by highly sensitive equipment to develop a characteristic signature based on wavelength. In this study, the colon tissue of six mice with the equivalent of Hirschsprungs disease was analyzed and compared to that of controls. With repeated measurements and calculations, unique signatures for normal tissue and for diseased tissue emerged.

Spectral imaging does not detect the presence or absence of ganglion cells themselves. Instead, the spectral signature reflects differences in the composition of normal and diseased tissue.

As a result of this study in laboratory mice, human clinical trials will be planned, providing spectral imaging for intraoperative decision-making in Hirschsprung's disease, a congenital condition affecting nerve cells of the large intestine. The technology, developed at Cedars-Sinais Minimally Invasive Surgical Technologies Institute (MISTI) is adaptable to other types of surgery.

Hirschsprungs usually affects specialized nerve (ganglion) cells in the lower portion of the large intestine, although the entire colon can be involved. Ganglion cells normally stimulate smooth muscle of the intestinal wall to push stool through the colon, but in sections where ganglia are missing (aganglionosis) the process comes to a halt, causing severe constipation that can lead to obstruction, massive infection and even death.

Estimated to affect one in 5,000
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Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
Source:Eurekalert

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