Navigation Links
Mouse studies advance treatment for common eye diseases
Date:9/3/2014

ood vessels in the eye less responsive to VEGF, but it also reduces leakage caused by other proteins that are active in eye diseases."

Working with mice genetically engineered to have vascular eye diseases, the team treated some with injections into the eye of an antibody that blocks an enzyme called VE-PTP. VE-PTP normally suppresses the pathway that reduces blood vessel growth and leakage, so the net effect was to activate the pathway.

The second method involved the use of a small molecule, AKB-9778, developed by Aerpio Therapeutics, which also blocks VE-PTP. Because of its size, AKB-9778 can easily enter the eye from the bloodstream, and the indirect action appears not to carry the same risks to the body as directly blocking VEGF, Campochiaro says. "If further studies show that the small molecule is safe and effective for people, patients could give themselves an injection under the skin every day," he says. "Our studies in animals so far suggest it doesn't have major side effects." If confirmed in clinical studies, this could reduce the need for patients to come in frequently to get injections in the eye. He says AKB-9778 may have the additional benefits of stabilizing blood vessels in other parts of the body and lowering blood pressure.

An estimated 2 million people in the United States suffer from age-related macular degeneration, with the incidence expected to rise to 3.5 million by 2030 and to 5.5 million by 2050. Roughly 20 percent of patients with age-related macular degeneration suffer from abnormal blood vessel growth and vascular leakage, says Campochiaro, and so may be helped by this new therapy, if it proves to work in clinical trials. An equally large number of patients have diabetic macular edema and could also potentially benefit from the treatment. The incidence of these diseases is increasing very quickly, because our population is aging and the number of patients with diabetes is increasing so rapidly, he says.


'/>"/>
Contact: Taylor Graham
tgraha10@jhmi.edu
443-287-8560
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mouse Study Hints at New Path for Diabetes Treatment
2. This mousetrap may save lives
3. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
4. Belly Membrane May Regulate Immune System, Mouse Study Finds
5. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
6. New mouse model helps explain gene discovery in congenital heart disease
7. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
8. Scientists develop mouse model that could lead to new therapies for liver cancer
9. Mouse With Human-Like Immune System Could Advance AIDS Research
10. A CNIO team creates a unique mouse model for the study of aplastic anaemia
11. Mouse model exposes a new type of T cell to target melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Precision Aesthetics ... eight years. It was also the first provider of Exilis non-surgical fat reduction ... sought after procedures it has attracted a large International clientele. Many patients travel ...
(Date:7/31/2015)... ... 31, 2015 , ... Last week, the Mesothelioma Applied Research ... be accessed by visiting http://www.curemeso.org/store . , “Our new store features a ... whenever a product is purchased, the Meso Foundation receives a $5.00 donation,” said ...
(Date:7/31/2015)... ... ... Sculpted Contours Luxury Medical Aesthetics announces the arrival of the newest applicator ... new applicator in the United States as an upgrade to the CoolSmooth applicator cleared ... applicator required a 2 hour treatment time. The new CoolSmooth Pro reduces the ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... important workshop at its new True North Conference Center. The medical community, social ... the Jacksonville community may be more aligned in the effort to better understand ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Coco Libre announced ... judges, media, and VIPs at the 2015 Vans US Open of Surfing, July 25 ... that can claim “no added sugar” on the market, is a natural choice given ...
Breaking Medicine News(10 mins):Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2
... uterus, the more likely she is to have a miscarriage, ... Journal of Medicine details the most precise information the timing ... its success or failure. ,Fertilised eggs can attach themselves ... 12 days after ovulation, the researchers from the National Institute ...
... the chances of getting bowel cancer, say scientists. Swedish ... and say that it points more firmly than ever to ... Research Campaing and Swedish Cancer Foundation, combined and analysed the ... It found that people who exercised regulatly were 50% less ...
... resposible for infertility.The virus is called adeno-associated virus (AAV) ... from men whose semen was abnormal. The virus was ... those with normal semen. ,Dr Jorg Schlehofer, ... research, said the virus should be assessed further to ...
... blood disorder that affects red blood cells. People with ... an abnormal type of hemoglobin. Sometimes these red blood ... blood vessels. When sickle-shaped cells clump together and obstruct ... to require hospital admission. // ,Researchers from ...
... among the deadliest of cancers, affecting many people a year ... the most aggressive cancer and there are few palliative treatments. ... deadly pancreatic cancer cells in the test tube and in ... Dr. Paul B. Fisher, a professor of clinical pathology at ...
... widely used anticancer drug, hydroxyurea, shows potent colon cancer-killing ... researchers. The new compounds seem to be very interesting ... ,Previous drugs derived from hydroxyurea were extremely active in ... serious side effects. This prompted the researchers to synthesize ...
Cached Medicine News:
(Date:7/30/2015)... a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare celebrates ... continue highlighting the success of the prescription drug benefit, commonly referred to as Part ... infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... THOUSAND OAKS, Calif. , July 30, 2015  Amgen ... Fred Hassan , partner and managing director of Warburg Pincus ... "We are pleased to welcome Fred Hassan and ... to the Amgen Board," said Robert A. Bradway , ... expertise and commitment to innovation will serve Amgen well." ...
(Date:7/30/2015)... VALLEY COTTAGE, New York , July 30, 2015 ... the release of its latest report titled, "Continuous Glucose ... 2015 - 2020". According to the report, the global ... 402.0 Mn in 2014 and is expected to reach ... 12.1% during the forecast period, 2015 to 2020. ...
Breaking Medicine Technology:Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
... Healthcare team, led by Tom Tobin, will host our next Black ... and Profits in Healthcare," where we will be discussing: ... good, and why the next decade looks so bad ... and spine device growth. -   The long term ...
... Laboratories, Inc. announced today the approval of its ... Tablets USP, 25mg, 50mg and 100mg as well ... 100mg/25mg by the U.S. Food and Drug Administration. ... wholesalers and pharmacies nationwide. Roxane Laboratories, ...
Cached Medicine Technology:Aging of America: Demographics of Demand and Profits in Healthcare 2Roxane Laboratories, Inc. Announces the Launch of Losartan Potassium Tablets USP and Losartan Potassium and Hydrochlorothiazide Tablets 2
This multiple-function instrument allows the surgeon to grasp, coagulate, and transect tissue with a single instrument, eliminating the need for multiple instruments and, in some procedures, costly l...
Bipolar forceps...
... An in vitro Nucleic Acid ... using Microplate Chemiluminescence for the ... (HPV) Types 6,11,16,18,31,33,35,39,42,43,44,45,51,52,56,58,59 and 68 ... Lowand High-Risk Groups in Cervical ...
... superb radiation protection-0.62mm (+/- .05)Pb lead glass ... to their level of protection, they are ... smoothly on your bridge while hugging your ... wear corrective lenses, you can order Leaded ...
Medicine Products: