Navigation Links
Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother
Date:3/11/2011

PHILADELPHIA - For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home.

Blending electrophysiological, biochemical, and behavioral experiments, Minghong Ma, PhD, an associate Professor of Neuroscience at the University of Pennsylvania School of Medicine, led a study published in a recent issue of the Journal of Neuroscience. With students Anderson Lee and Jiwei He, she demonstrated that neurons in the noses of mice mature after birth.

Using patch-clamping a technique that measures electrical signals at the cellular level -- Ma's team found that between birth and day 30 of development, normal neurons become six times more sensitive to their sibling's scent, in this case, a fragrance called lyral. In addition, the mice transition from a relative indiscriminate response to different odors to being highly attuned to one specific smell. They also respond to that specific odor with a faster speed over time.

The olfactory marker protein (OMP) likely mediates this developmental maturation. In olfactory sensory neurons lacking OMPs, response fails to speed up over 30 days as compared to normal neurons. The authors suggest this could be due to altered intracellular communication, since loss of the protein is associated with decreased phosphorylation of an associated enzyme called adenylate cyclase, a key player in the chemical signaling underlying the sense of smell.

The team also used a novel behavioral assay to illustrate one consequence of mistakes in this cellular maturation process. Normal mouse pups, given the choice between their mother and an unrelated, lactating female, will choose to huddle with or suckle their mother 78 percent of the time. But in the absence of OMP, newborn mice fail to make that distinction.

According to Ma, the maturation of olfaction in early development could offer animals that need nursing and care for a long time before maturing (altricial species, including some mammals) a survival advantage. Rather than being hard-wired at birth, Ma says, they learn to identify their surroundings and their family. "They actually learn to find their mother, home, and siblings, and to stay alive," she says. But whether the same is true of human infants, of course, remains an open question.

One key question yet to be addressed, Ma says, is the mechanism underlying this olfactory tuning process. How, for instance, do the cells develop a faster response speed? How do they get so good at focusing on just one odorant to the exclusion of all others? And can this process be modulated by early experience? The answers to those questions, she says, could possibly provide tools to influence the bonding between mother and child in early development, and even promote social interactions in autistic children.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Rapamycin rescues learning, memory in Alzheimers mouse model
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Dxtra Introduces New Solid Stainless Steel Mouse Pad
4. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
5. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
6. Fat in Males, Females Differs Genetically, Mouse Study Shows
7. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
8. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
9. Treatment for S. aureus skin infection works in mouse model
10. Mouse Study May Help Explain Fish Oils Benefits
11. Mouse Study Reveals a Cancer Cell Escape Route
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... September 21, 2017 , ... Promotional Communication:, ... http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world of drug and device marketing and ... compliance with FDA rules. , The FDA has issued two draft guidances that ...
(Date:9/21/2017)... ... September 21, 2017 , ... In addition to sticking with ... more holistic approach and use natural alternatives for all house cleaning products, disinfectants, ... USDA guaranteeing that, the new line of essential oils, are all 100% organic ...
(Date:9/21/2017)... ... September 21, 2017 , ... Japanese Zen artist couple, ... Revolution” on 6th, 7th and 8th October at Miranda Kuo Gallery on Lower East ... pieces, such as Zen Kodo mat. Wanderlust , one of the largest US ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... serving communities in northern Alabama and Georgia, is embarking on an extended charity ... utilizing modern early detection methods. , US Breast Cancer statistics show that ...
(Date:9/20/2017)... ... September 20, 2017 , ... Collins Concrete ... for clients that rely on safety and cleanliness. This unique flooring system uses ... has been used for centuries for its antimicrobial properties. Unlike antibiotics, which kill ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform ... published the first annual edition of its Global CSR Risk and Performance ... evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data ... ... ...
(Date:9/9/2017)... Sept. 9, 2017  Eli Lilly and Company (NYSE: ... secondary endpoint data for lasmiditan, an investigational, oral, first-in-class ... statistically significant improvements compared to placebo in the Phase ... at the 18th Congress of the International Headache Society ... "The data presented today demonstrate lasmiditan,s potential to reduce ...
(Date:9/7/2017)... Ind. , Sept. 7, 2017  Zimmer Biomet ... in musculoskeletal healthcare, today announced that it will be ... Global Healthcare Conference at the Grand Hyatt hotel in ... 11, 2017 at 11:40 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
Breaking Medicine Technology: