Navigation Links
Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother
Date:3/11/2011

PHILADELPHIA - For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home.

Blending electrophysiological, biochemical, and behavioral experiments, Minghong Ma, PhD, an associate Professor of Neuroscience at the University of Pennsylvania School of Medicine, led a study published in a recent issue of the Journal of Neuroscience. With students Anderson Lee and Jiwei He, she demonstrated that neurons in the noses of mice mature after birth.

Using patch-clamping a technique that measures electrical signals at the cellular level -- Ma's team found that between birth and day 30 of development, normal neurons become six times more sensitive to their sibling's scent, in this case, a fragrance called lyral. In addition, the mice transition from a relative indiscriminate response to different odors to being highly attuned to one specific smell. They also respond to that specific odor with a faster speed over time.

The olfactory marker protein (OMP) likely mediates this developmental maturation. In olfactory sensory neurons lacking OMPs, response fails to speed up over 30 days as compared to normal neurons. The authors suggest this could be due to altered intracellular communication, since loss of the protein is associated with decreased phosphorylation of an associated enzyme called adenylate cyclase, a key player in the chemical signaling underlying the sense of smell.

The team also used a novel behavioral assay to illustrate one consequence of mistakes in this cellular maturation process. Normal mouse pups, given the choice between their mother and an unrelated, lactating female, will choose to huddle with or suckle their mother 78 percent of the time. But in the absence of OMP, newborn mice fail to make that distinction.

According to Ma, the maturation of olfaction in early development could offer animals that need nursing and care for a long time before maturing (altricial species, including some mammals) a survival advantage. Rather than being hard-wired at birth, Ma says, they learn to identify their surroundings and their family. "They actually learn to find their mother, home, and siblings, and to stay alive," she says. But whether the same is true of human infants, of course, remains an open question.

One key question yet to be addressed, Ma says, is the mechanism underlying this olfactory tuning process. How, for instance, do the cells develop a faster response speed? How do they get so good at focusing on just one odorant to the exclusion of all others? And can this process be modulated by early experience? The answers to those questions, she says, could possibly provide tools to influence the bonding between mother and child in early development, and even promote social interactions in autistic children.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Rapamycin rescues learning, memory in Alzheimers mouse model
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Dxtra Introduces New Solid Stainless Steel Mouse Pad
4. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
5. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
6. Fat in Males, Females Differs Genetically, Mouse Study Shows
7. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
8. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
9. Treatment for S. aureus skin infection works in mouse model
10. Mouse Study May Help Explain Fish Oils Benefits
11. Mouse Study Reveals a Cancer Cell Escape Route
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: