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Mouse model improves understanding of clear cell sarcoma
Date:2/11/2013

e must be injected into a mouse after birth.

Along with opening new avenues to understand and potentially treat CCS, the new mouse model also can help researchers learn more about carcinomas, the more common forms of human cancer, Capecchi believes. Carcinomas occur in the tissue that forms the inner and outer surfaces of organs, glands, and body cavities. These types of cancers require multiple steps and take a long time to develop, making them more difficult to study.

"My feeling is that identifying the different steps that give rise to CCS tumors may be informative on how carcinomas develop." Capecchi says. "Sarcomas are genetically more stable than carcinomas, which makes it easier to identify the events leading to the cancer. Learning about CCS might shed light on carcinomas."

There are more than 20 types of sarcoma, each with a different fusion gene, according to Capecchi.


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Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

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