Navigation Links
Mouse menopause model sheds light on UTIs in post-menopausal women
Date:1/24/2013

Researchers from Washington University School of Medicine, St. Louis, show that reservoirs of uropathogenic E. coli within the bladder exist in higher numbers post-menopause than pre-menopause in a mouse model, a finding that could help explain the greater prevalence of urinary tract infections in post-menopausal women. They also found that estrogen supplementation reduced the numbers of such reservoirs dramatically. The research was published online ahead of print in the journal Infection and Immunity.

Urinary tract infections (UTIs) afflict an estimated 13 million American women annually. Post-menopausal women are especially vulnerable to UTIs. The high incidence of UTIs in post-menopausal women has long been thought related to the menopausal fall in estrogen levels.

However, "estrogen therapy to help limit or prevent recurrent or chronic UTIs has not been consistently shown to be effective in reducing the burden of infections in this population," says Indira Mysorekar, a researcher on the study. "Given the increasing incidence of multidrug resistant bugs and the high incidence of UTIs in older women, it is vital that we fully understand the dynamics of estrogen interaction with uropathogenic Escherichia coli, and the course of UTIs, and model these to determine how they might intersect."

Uropathogenic E. coli also damage the bladder, says Mysorekar. "To repair the damage, new cells are produced that turn into specialized cells which make up the new bladder barrier," she says. "In the absence of estrogen," as in post-menopausal women, "this repair process was severely disrupted." Among other things, abnormally elevated levels of immune system cytokines may damage bladder cells. In the mouse menopause model, "the cytokine levels are very high," she says. However, the researchers found that estrogen supplementation can reduce the levels of cytokines, as well as the infectious reservoirs to levels found pre-menopausally, mitigating the infection and the resulting damage.

The goal of the current research was "to develop a definitive model of UTIs in menopause, to understand both the effect of loss of estrogen on the course of infection, and to determine whether estrogen therapy would be effective," says Mysorekar.

"The long term goal of my lab is to identify the molecular and genetic pathways that govern the estrogenic regulation of normal bladder function, and how it is altered during bladder disease and in menopause," says Mysorekar. "Our findings lay the groundwork for exploring the mechanism of estrogenic action and for testing hormone therapy efficacy in our animal model, and eventually in humans."

UTI symptoms include frequent urination, often accompanied by a burning sensation, cloudy, bad-smelling urine, and pelvic pain. They can be dangerous if they spread to the kidneys.


'/>"/>
Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Mouse Study Offers Clues to Obesity-Diabetes Link
2. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
3. New, improved mouse model of human Alzheimers may enable drug discovery
4. Mouse model exposes a new type of T cell to target melanoma
5. A CNIO team creates a unique mouse model for the study of aplastic anaemia
6. Mouse With Human-Like Immune System Could Advance AIDS Research
7. Scientists develop mouse model that could lead to new therapies for liver cancer
8. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
9. New mouse model helps explain gene discovery in congenital heart disease
10. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
11. Belly Membrane May Regulate Immune System, Mouse Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Itopia, a ... the integration of Clarity Intelligence Platform (CIP) into Cielo®, a discovery, migration and ... intelligence (BI) to their small and medium business (SMB) clients. , ...
(Date:2/12/2016)... ... 12, 2016 , ... Vail knee specialist Robert LaPrade, MD, PhD ... . The list consists of physicians establishing, leading and partnering with ambulatory surgery centers ... An Ambulatory Surgery Center, also known as an ASC, is a modern health care ...
(Date:2/12/2016)... , ... February 12, 2016 , ... For Coast Dental ... Suzan Sweeney, RDH, and dental assistant Terrell Moore shortly before 7 a.m. to volunteer ... of dental professionals, donating their time and skills to help hundreds of uninsured and ...
(Date:2/12/2016)... Malvern, Pa. (PRWEB) , ... February 12, 2016 ... ... help sort through a world of exterior design possibilities. CertainTeed, North America’s leading ... visualization tools by expanding the product offerings showcased in the mobile version of ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... creating explosive growth in the field of long term care. With that, says ... for well-trained healthcare professionals in administrative roles in long term care environments. His ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... --> ... Global Clinical Trials Review, H2, 2015 provides an ... trials landscape along with top level data related ... & E7), Trial Status, Trial Phase, Sponsor Type ... involved and enlists all trials (Trial title, Phase, ...
(Date:2/11/2016)... 11, 2016 Stem cells are primitive cells ... self-renewal and the capacity to differentiate into mature cell ... as the first mouse embryonic stem cells were derived ... 1995 that the first culturing of embryonic stem cells ... not produced until 2006 As a result of these ...
(Date:2/11/2016)... -- Kindred Biosciences, Inc. (NASDAQ: KIN ), a biopharmaceutical ... pets, today announced the submission to FDA of the ... (NADA) for Zimeta™ (dipyrone injection, KIND-012).  Positive topline results ... the control of pyrexia (fever) in horses were recently ... --> The Chemistry, Manufacturing, and Controls technical ...
Breaking Medicine Technology: