Navigation Links
Mouse menopause model sheds light on UTIs in post-menopausal women
Date:1/24/2013

Researchers from Washington University School of Medicine, St. Louis, show that reservoirs of uropathogenic E. coli within the bladder exist in higher numbers post-menopause than pre-menopause in a mouse model, a finding that could help explain the greater prevalence of urinary tract infections in post-menopausal women. They also found that estrogen supplementation reduced the numbers of such reservoirs dramatically. The research was published online ahead of print in the journal Infection and Immunity.

Urinary tract infections (UTIs) afflict an estimated 13 million American women annually. Post-menopausal women are especially vulnerable to UTIs. The high incidence of UTIs in post-menopausal women has long been thought related to the menopausal fall in estrogen levels.

However, "estrogen therapy to help limit or prevent recurrent or chronic UTIs has not been consistently shown to be effective in reducing the burden of infections in this population," says Indira Mysorekar, a researcher on the study. "Given the increasing incidence of multidrug resistant bugs and the high incidence of UTIs in older women, it is vital that we fully understand the dynamics of estrogen interaction with uropathogenic Escherichia coli, and the course of UTIs, and model these to determine how they might intersect."

Uropathogenic E. coli also damage the bladder, says Mysorekar. "To repair the damage, new cells are produced that turn into specialized cells which make up the new bladder barrier," she says. "In the absence of estrogen," as in post-menopausal women, "this repair process was severely disrupted." Among other things, abnormally elevated levels of immune system cytokines may damage bladder cells. In the mouse menopause model, "the cytokine levels are very high," she says. However, the researchers found that estrogen supplementation can reduce the levels of cytokines, as well as the infectious reservoirs to levels found pre-menop
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mouse Study Offers Clues to Obesity-Diabetes Link
2. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
3. New, improved mouse model of human Alzheimers may enable drug discovery
4. Mouse model exposes a new type of T cell to target melanoma
5. A CNIO team creates a unique mouse model for the study of aplastic anaemia
6. Mouse With Human-Like Immune System Could Advance AIDS Research
7. Scientists develop mouse model that could lead to new therapies for liver cancer
8. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
9. New mouse model helps explain gene discovery in congenital heart disease
10. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
11. Belly Membrane May Regulate Immune System, Mouse Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Atlanta, Georgia (PRWEB) September 18, 2014 ... announced the winners of its 2nd TAG Social Savvy ... the Junior Achievement’s Chick-fil-A Foundation Discovery Center in Downtown ... social media. , Turner Sports was honored with ... This year’s event also recognized innovators in 6 ...
(Date:9/18/2014)... A sold-out crowd of more than ... supported United Way of Westchester and Putnam ... event Monday, Sept. 15. Proceeds from the event will ... and Putnam, such as providing healthy foods to low-income ... risky behaviors like drug and alcohol usage. , Two ...
(Date:9/18/2014)... News) -- Teens and young adults who,ve been mentored ... provides them with greater responsibility and independence early on ... "We found that having a mentor provides a clear ... author, Steve McDonald, an associate professor of sociology at ... release. In conducting the study, published online ...
(Date:9/18/2014)... show promise in slowing the progression of mesothelioma, ... to asbestos. Scientists from Case Western Reserve University ... application of curcumin, a derivative of the spice ... protein inhibitor known to combat the progression of ... 14 online edition Clinical Cancer Research ; ...
(Date:9/18/2014)... Research led by Paulo Rodriguez, PhD, an assistant ... Health New Orleans, Stanley S. Scott Cancer Center, has ... Chop plays in the body,s ability to fight cancer. ... the activity and accumulation of cells that suppress the ... Orleans research team showed that when they removed Chop, ...
Breaking Medicine News(10 mins):Health News:Winners Honored at 2014 TAG Social Savvy Awards 2Health News:Winners Honored at 2014 TAG Social Savvy Awards 3Health News:United Way Celebrates “Best Chefs and Fine Wines” at Sold-Out Culinary Event 2Health News:United Way Celebrates “Best Chefs and Fine Wines” at Sold-Out Culinary Event 3Health News: Mentors May Steer Young People Toward More Rewarding Careers 2Health News:Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma 2Health News:Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize STAT3 in mesothelioma 3Health News:LSU Health research discovers means to free immune system to destroy cancer 2
... of heart disease. But almost everyone feels that exercising is ... that skinny people are also prone to developing heart diseases ... genesis of various heart ailments. ,Dr. Peter T. Katzmarzyk ... study, says that heart disease does not develop from a ...
... is playing havoc with the economies of,developed countries like ... of vaccinating the animals for the past three decades. ... regular basis is the best,means of preventing the spread ... joint,director of the Bangalore-based Indian Veterinary Research Institute (under,ICAR), ...
... government says that smoking will turn out to be the ... of even HIV. The British broadcasting corporation reported on Monday ... than any other disease in the next 20 years. The ... United Kingdom, says smoking and other tobacco related deaths would ...
... has zeroed in on the culprit behind the falling age ... said to be the cause for girls attaining puberty as ... explanation for this is growing childhood obesity, intake of rich ... the role of estrogen, a female hormone, in attaining puberty.,They ...
... Most people are paranoid about heart disease. One survey said ... hepatitis and heart disease. Whenever people get to read something ... they start worrying at times over trivial problems based on ... recent study conducted in Austria says that chronic infections can ...
... an associate professor of computer science at the Washington ... the way children understand and speak languages at such ... meeting of the American association for the advancement of ... to pick up language and to become familiar with ...
Cached Medicine News:Health News:India takes on foot-and-mouth disease by vaccinating animals 2
(Date:9/18/2014)... Pharma IQ, after huge demand ... Countdown calendar to cover the years 2014 - 2018 ... shows the serialisation requirements around the globe and the ... For companies dealing with international markets, serialisation ... they will have to comply with new regulations coming ...
(Date:9/18/2014)... 2014   3D Systems   (NYSE: DDD ... Mentor™ , a new robotic surgery skills and procedural training ... the ERUS exhibition in Amsterdam, The Netherlands ... Robotic-assisted minimally invasive surgery represents a growing portion of overall ... training for robotic surgery has increased, and it is expected ...
(Date:9/18/2014)... 2014 After 6 months of careful ... here - the new programme for the next Cool Chain ... our global Cool Chain series, has just been released! ... As the lines between supply chain, logistics, QA and ... that is broad and yet specific, focused and yet accessible, ...
Breaking Medicine Technology:Pharma IQ Displays Worldwide Serialisation Deadlines in their 2014 - 2018 Countdown Calendar 23D Systems Introduces New Simbionix Robotics Training Platform 23D Systems Introduces New Simbionix Robotics Training Platform 3Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2
... , WASHINGTON, Nov. 24 ... and vaccines to treat or prevent HIV/AIDS and related conditions, according ... Manufacturers of America (PhRMA). December 1 marks the 21st anniversary of ... the 1988 World Summit of Ministers of Health on Programmes for ...
... , NORTH HOLLYWOOD, Calif., Nov. 24 ... national hospitalist physician group practice company, announced today that Philip Vaidyan, ... as one of the 2009 Top Ten Hospitalists in the ... magazine. , Dr. Vaidyan has been a practicing physician for more ...
Cached Medicine Technology:New Report Shows 97 Medicines and Vaccines Currently in Development for HIV/AIDS 2New Report Shows 97 Medicines and Vaccines Currently in Development for HIV/AIDS 3IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 2IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 3
For the qualitative detection of human Chorionic Gonadotrophin (HCG) in urine or urine and serum specimens...
ZyDoc offers a full medical transcription and documentation solution....
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: