Navigation Links
Mouse menopause model sheds light on UTIs in post-menopausal women
Date:1/24/2013

Researchers from Washington University School of Medicine, St. Louis, show that reservoirs of uropathogenic E. coli within the bladder exist in higher numbers post-menopause than pre-menopause in a mouse model, a finding that could help explain the greater prevalence of urinary tract infections in post-menopausal women. They also found that estrogen supplementation reduced the numbers of such reservoirs dramatically. The research was published online ahead of print in the journal Infection and Immunity.

Urinary tract infections (UTIs) afflict an estimated 13 million American women annually. Post-menopausal women are especially vulnerable to UTIs. The high incidence of UTIs in post-menopausal women has long been thought related to the menopausal fall in estrogen levels.

However, "estrogen therapy to help limit or prevent recurrent or chronic UTIs has not been consistently shown to be effective in reducing the burden of infections in this population," says Indira Mysorekar, a researcher on the study. "Given the increasing incidence of multidrug resistant bugs and the high incidence of UTIs in older women, it is vital that we fully understand the dynamics of estrogen interaction with uropathogenic Escherichia coli, and the course of UTIs, and model these to determine how they might intersect."

Uropathogenic E. coli also damage the bladder, says Mysorekar. "To repair the damage, new cells are produced that turn into specialized cells which make up the new bladder barrier," she says. "In the absence of estrogen," as in post-menopausal women, "this repair process was severely disrupted." Among other things, abnormally elevated levels of immune system cytokines may damage bladder cells. In the mouse menopause model, "the cytokine levels are very high," she says. However, the researchers found that estrogen supplementation can reduce the levels of cytokines, as well as the infectious reservoirs to levels found pre-menopausally, mitigating the infection and the resulting damage.

The goal of the current research was "to develop a definitive model of UTIs in menopause, to understand both the effect of loss of estrogen on the course of infection, and to determine whether estrogen therapy would be effective," says Mysorekar.

"The long term goal of my lab is to identify the molecular and genetic pathways that govern the estrogenic regulation of normal bladder function, and how it is altered during bladder disease and in menopause," says Mysorekar. "Our findings lay the groundwork for exploring the mechanism of estrogenic action and for testing hormone therapy efficacy in our animal model, and eventually in humans."

UTI symptoms include frequent urination, often accompanied by a burning sensation, cloudy, bad-smelling urine, and pelvic pain. They can be dangerous if they spread to the kidneys.


'/>"/>
Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Mouse Study Offers Clues to Obesity-Diabetes Link
2. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
3. New, improved mouse model of human Alzheimers may enable drug discovery
4. Mouse model exposes a new type of T cell to target melanoma
5. A CNIO team creates a unique mouse model for the study of aplastic anaemia
6. Mouse With Human-Like Immune System Could Advance AIDS Research
7. Scientists develop mouse model that could lead to new therapies for liver cancer
8. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
9. New mouse model helps explain gene discovery in congenital heart disease
10. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
11. Belly Membrane May Regulate Immune System, Mouse Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... 04, 2016 , ... Are You Concerned About Mold In Your Home or ... Air Quality Companies in VA, MD and DC, recently completed its application for the ... mold law in the district of Columbia is a good thing stated John Taylor, ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... on the perils of heroin that was watched live by 1 million viewers ... I. duPont-Columbia University Award. , ASU students at the Walter Cronkite School of ...
(Date:12/2/2016)... CO (PRWEB) , ... December 02, 2016 , ... Advanced ... announced it has appointed Jason Bice, CPA, MBA to serve as Advanced Inc.’s Chief ... for Advanced, Inc. , Jason brings extensive financial and operational leadership experience to ...
(Date:12/2/2016)... , ... December 02, 2016 , ... U.S. Surgeon General, ... with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at an ... that medicine is about more than making diagnoses and prescribing medicine,” he states. “It ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... WOONSOCKET, R.I. , Dec. 2, 2016 ... hold its annual Analyst Day in New York City on Thursday, December ... the CVS Health leadership team will provide an in-depth ... and enhance shareholder value. The company will also discuss ... audio and video webcast of the event will be ...
(Date:12/2/2016)... -- Orthopedic Implants (Including Spinal Implants, Reconstructive Joint ... a Significant Market Share Owing to a Large Global Baby ... ... According to a new report by Persistence Market Research ... Product Type Segment Projected to Witness a Significantly High CAGR ...
(Date:12/2/2016)... 2, 2016   CytoSorbents Corporation (NASDAQ: ... European Union approved CytoSorb ® cytokine adsorber to ... worldwide, announced that Dr. Phillip Chan , Chief ... LD Micro Main Event investor conference held from ... Luxe Sunset Boulevard Hotel in Los Angeles, ...
Breaking Medicine Technology: