Navigation Links
Mouse menopause model sheds light on UTIs in post-menopausal women
Date:1/24/2013

Researchers from Washington University School of Medicine, St. Louis, show that reservoirs of uropathogenic E. coli within the bladder exist in higher numbers post-menopause than pre-menopause in a mouse model, a finding that could help explain the greater prevalence of urinary tract infections in post-menopausal women. They also found that estrogen supplementation reduced the numbers of such reservoirs dramatically. The research was published online ahead of print in the journal Infection and Immunity.

Urinary tract infections (UTIs) afflict an estimated 13 million American women annually. Post-menopausal women are especially vulnerable to UTIs. The high incidence of UTIs in post-menopausal women has long been thought related to the menopausal fall in estrogen levels.

However, "estrogen therapy to help limit or prevent recurrent or chronic UTIs has not been consistently shown to be effective in reducing the burden of infections in this population," says Indira Mysorekar, a researcher on the study. "Given the increasing incidence of multidrug resistant bugs and the high incidence of UTIs in older women, it is vital that we fully understand the dynamics of estrogen interaction with uropathogenic Escherichia coli, and the course of UTIs, and model these to determine how they might intersect."

Uropathogenic E. coli also damage the bladder, says Mysorekar. "To repair the damage, new cells are produced that turn into specialized cells which make up the new bladder barrier," she says. "In the absence of estrogen," as in post-menopausal women, "this repair process was severely disrupted." Among other things, abnormally elevated levels of immune system cytokines may damage bladder cells. In the mouse menopause model, "the cytokine levels are very high," she says. However, the researchers found that estrogen supplementation can reduce the levels of cytokines, as well as the infectious reservoirs to levels found pre-menop
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mouse Study Offers Clues to Obesity-Diabetes Link
2. Bright Light at Night Could Up Depression Risk, Mouse Study Suggests
3. New, improved mouse model of human Alzheimers may enable drug discovery
4. Mouse model exposes a new type of T cell to target melanoma
5. A CNIO team creates a unique mouse model for the study of aplastic anaemia
6. Mouse With Human-Like Immune System Could Advance AIDS Research
7. Scientists develop mouse model that could lead to new therapies for liver cancer
8. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
9. New mouse model helps explain gene discovery in congenital heart disease
10. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
11. Belly Membrane May Regulate Immune System, Mouse Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Recently ... know in predictive health analytics , Jvion continues to disrupt the predictive ... predictive software that targets patient and population level illness to drive prevention and ...
(Date:7/31/2015)... GA (PRWEB) , ... July 31, 2015 , ... Sculpted ... , the CoolSmooth PRO this week. Zeltiq Aesthetics released this new applicator in ... in January 2014 for treating the outer thighs. The original applicator required a ...
(Date:7/31/2015)... Meadows, IL (PRWEB) , ... July 31, 2015 ... ... ways to communicate. Rally Insurance Group, Inc. has re-branded their social media profiles ... provides a personal way for consumers to communicate, find information, share insights and ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source of ... catch a new and refreshing show on Broadway, look no further than Hamilton. This ... Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and New ...
(Date:7/31/2015)... ... July 31, 2015 , ... Well-known for its unique pastries and ... cakes with custom designs, making life just a little bit sweeter for newlyweds. ... for each customer who orders one. , The bakery provides a full line of ...
Breaking Medicine News(10 mins):Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... Dairy Daily, SACRAMENTO, Calif., March 11 Reducing ... as drinking low-fat milk with meals,according to new research., ... or more daily servings,of low-fat dairy products were 11 ... the Brigham and Women,s Hospital in Boston,attributed the benefit ...
... AARP Services Inc. and,Genworth Financial, Inc. (NYSE: ... a,new long term care insurance plan for AARP,s ... affordable alternative to traditional,long term care insurance and ... with more states anticipated., (Logo: http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ...
... Emory University School of Medicine and Children,s Healthcare of ... California to find new ways to make kidney transplants ... will partner with UCLA,s Mattel Childrens Hospital in Los ... Palo Alto for a study of kidney transplants in ...
... release is available in German . , ... themselves by programmed cell death, or apoptosis. Therefore, tumors ... effect is based on forcing tumor cells to commit ... by defects in one of the numerous molecular switches ...
... Down Boundaries That Can Limit Treatment Options ... for Older Colorectal Cancer Patients, ... announce today the 2008 award recipients of the,Breaking Boundaries program, ... down the boundaries that can limit appropriate treatment,of older colorectal ...
... a healthier start to life through ... running and physical fitness, ATLANTA, March 11 ... of running shoes and orange,shoelaces on Sunday, March 30 as he partners ... during the 2008 ING,Georgia Marathon and Half Marathon., Brooking, who plays ...
Cached Medicine News:Health News:Low-Fat Dairy Reduces High Blood Pressure Risk 2Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 2Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 3Health News:AARP Services Inc. and Genworth Financial Introduce New Innovative and Affordable Long Term Care Insurance Option to AARP Members 4Health News:NIH grant to Emory and pediatric partners aims to improve kidney transplants for children 2Health News:Paradigm shift: Switch for programmed cell death promotes spread of glioblastoma 2Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 2Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 3Health News:Breaking Boundaries Program Honors Colorectal Cancer Survivors for Outstanding Leadership Achievements 4Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 2Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 3Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 4Health News:Atlanta Falcons Linebacker Keith Brooking Prepares to 'Run for Something Better' at ING Georgia Marathon 5
(Date:7/31/2015)... WOODCLIFF LAKE, N.J. and SAN ... announced today that its parent company Eisai Co., Ltd. ... Haruo Naito , "Eisai") and Halozyme Therapeutics, Inc. ... and CEO: Dr. Helen Torley , "NASDAQ: HALO") ... eribulin mesylate (brand name: Halaven ® , "eribulin") in ...
(Date:7/30/2015)... 30, 2015 Mettler-Toledo International Inc. (NYSE: ... Provided below are the highlights: , Sales ... with the prior year. Reported sales decreased 4% as ... , Net earnings per diluted share as reported ... period. Adjusted EPS was $2.80 , an increase ...
(Date:7/30/2015)... IRVINE, Calif. , July 30, 2015 /PRNewswire/ ... Novartis /Alcon executives have recently contacted the Company ... will begin as early as Monday, August 3, ... been quoted as saying that the coming electronic ... billions of dollars over the next several years.  ...
Breaking Medicine Technology:Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14
... in lupus research was met this weekend!  On Saturday, October 22 ... annual New York City Walk with Us to Cure Lupus ... enthusiasm of the nearly 3000 walkers in attendance to walk for ... My9 news anchor Brenda Blackmon, ALR Chairman Robert Wood Johnson IV, ...
... 2011 Connectyx (Other OTC:  CTYX) - Connectyx ... that the Company will be hosting a nationwide ... EST, to discuss the company,s third quarter financials, ... advertising campaigns encompassing their health and wellness program ...
Cached Medicine Technology:Alliance for Lupus NYC Walk With Us to Cure Lupus First Lupus Walk In History To Raise $1-Million 2Connectyx Technologies to Host Teleconference on Third Quarter Financial Results on Tuesday November 15, 2011 2Connectyx Technologies to Host Teleconference on Third Quarter Financial Results on Tuesday November 15, 2011 3
Specimen-ID™, a Positive Specimen Identification System, assures the permanent link at the bedside between patient and laboratory specimen to prevent sample identification errors....
wCareMed™ utilizes barcode scanning technology to support medication administration. It is a simple to use point of care application that provides access to patient information on a lightweight,...
... Korchek Technologies CareChek Rx ... barcode technology, Windows CE ... integrated scanners (to perform ... the bedside) and an ...
... conjunction with the AutoPPI barcoded wristband, manages ... a specific patient. The system ensures that ... correct patient and provides printed medication delivery ... keeps a record of the caregiver, location ...
Medicine Products: