Navigation Links
Mouse mammary tumor virus can replicate in human cells
Date:10/10/2007

Mouse mammary tumor virus (MMTV) - which causes mammary cancer in mice - can replicate and spread in human cells, research published this week shows. The study, published in the online open access journal Retrovirology, adds weight to the theory that MMTV might be involved in causing human breast cancer.

The idea that MMTV is involved in human breast cancer has been around for over 50 years. In the 1990s, researchers detected MMTV in human breast tumors, but not in healthy breast tissue. The link between MMTV and human breast cancer was contentious though, as some scientists believed the presence of MMTV in tumors was caused by contamination rather than infection.

However, two years ago, researchers from the University of Veterinary Medicine, Austrianova Biotechnology and the Christian-Doppler Laboratory for Gene Therapeutic Vector Development, all based in Vienna, Austria, showed that MMTV does actually infect human cells.

Now, they have added to these findings with this latest study, which shows that MMTV can replicate in cultured human breast cells. The new virus particles produced by the infected cells enabled the virus to spread rapidly, leading to the infection of every cell in culture.

"It has recently been shown convincingly that MMTV can infect human cells. Often, however, viruses infect cells but cannot replicate further. If they can replicate, the chances that they cause disease may be increased," says Dr Stanislav Indik from the University of Veterinary Medicine, Vienna and one of the study's authors.

There are a number of questions still to be answered before a concrete role of MMTV in human breast cancer is established, including whether MMTV can infect primary cells - those taken directly from the body, not from a cultured cell line. Also, researchers plan to investigate how the virus spreads from mice to humans, and to examine if one of the possible outcomes of human MMTV infection is breast cancer.

MMTV is a retrovirus, the same kind of virus as HIV. If MMTV is eventually found to play a role in human breast cancer, current treatments for HIV may also be effective against MMTV.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: