Navigation Links
Mouse mammary tumor virus can replicate in human cells
Date:10/10/2007

Mouse mammary tumor virus (MMTV) - which causes mammary cancer in mice - can replicate and spread in human cells, research published this week shows. The study, published in the online open access journal Retrovirology, adds weight to the theory that MMTV might be involved in causing human breast cancer.

The idea that MMTV is involved in human breast cancer has been around for over 50 years. In the 1990s, researchers detected MMTV in human breast tumors, but not in healthy breast tissue. The link between MMTV and human breast cancer was contentious though, as some scientists believed the presence of MMTV in tumors was caused by contamination rather than infection.

However, two years ago, researchers from the University of Veterinary Medicine, Austrianova Biotechnology and the Christian-Doppler Laboratory for Gene Therapeutic Vector Development, all based in Vienna, Austria, showed that MMTV does actually infect human cells.

Now, they have added to these findings with this latest study, which shows that MMTV can replicate in cultured human breast cells. The new virus particles produced by the infected cells enabled the virus to spread rapidly, leading to the infection of every cell in culture.

"It has recently been shown convincingly that MMTV can infect human cells. Often, however, viruses infect cells but cannot replicate further. If they can replicate, the chances that they cause disease may be increased," says Dr Stanislav Indik from the University of Veterinary Medicine, Vienna and one of the study's authors.

There are a number of questions still to be answered before a concrete role of MMTV in human breast cancer is established, including whether MMTV can infect primary cells - those taken directly from the body, not from a cultured cell line. Also, researchers plan to investigate how the virus spreads from mice to humans, and to examine if one of the possible outcomes of human MMTV infection is breast cancer.

MMTV is a retrovirus, the same kind of virus as HIV. If MMTV is eventually found to play a role in human breast cancer, current treatments for HIV may also be effective against MMTV.


'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health ... Miles by Moonlight to raise money for the American Heart Association Heart Walk. Teams ... Teams will work together to keep their treadmills moving for 5 hours. Treadmills will ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  BioPharmX Corporation (NYSE MKT: ... that developed an innovative way to use nonlinear optical ... delivery of new drugs. ... Dermatology Conference will show how researchers from BioPharmX and ... Medical School used a suite of imaging techniques in ...
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
Breaking Medicine Technology: