Navigation Links
Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis
Date:6/13/2012

WEDNESDAY, June 13 (HealthDay News) -- Certain types of saturated fats common in today's Western diet may change gut bacteria and trigger inflammatory bowel disease in people genetically predisposed to the disorder, according to a new study that looked at this relationship in mice.

Inflammatory bowel disease includes ulcerative colitis and Crohn's disease.

The University of Chicago researchers said their findings help explain why once rare immune-system-related disorders such as inflammatory bowel disease have become more common in the United States and other Westernized nations in the last half-century.

The researchers said their study may shed some light on why many people who are genetically prone to the condition still don't develop it and how certain environmental factors can cause inflammation in those at risk.

Scientists note, however, that research with animals often fails to provide similar results in humans.

Working with mice with characteristics of human inflammatory bowel disease, the researchers found that concentrated milk fats alter the composition of bacteria in the intestines. These changes can alter the fragile truce between the immune system and the complex but largely beneficial mix of bacteria in the intestines.

Harmful bacteria can trigger an unregulated tissue-damaging immune-system response that can be difficult to turn off, according to the study published online June 13 in the journal Nature.

Concentrated milk fats are used widely in processed and confectionary foods, the researchers noted.

The same response was not seen with polyunsaturated fats, which are found in plant-based foods and oils.

"This is the first plausible mechanism showing step by step how Western-style diets contribute to the rapid and ongoing increase in the incidence of inflammatory bowel disease," study author Dr. Eugene Chang, a professor of medicine at the University of Chicago, said in a university news release.

"We know how certain genetic differences can increase the risk for these diseases, but moving from elevated risk to the development of disease seems to require a second event that may be encountered because of our changing lifestyle," he said.

Not much can be done to correct genes that increase a person's risk for inflammatory bowel disease, and getting people to change their diets is often difficult and seldom effective, Chang said.

"However, the balance between host and microbes can be altered back to a healthy state to prevent or treat these diseases," he added. "In essence, the gut microbiome can be 'reshaped' in ... ways that restore a healthy relationship between host and microbes, without significantly affecting the lifestyles of individuals who are genetically prone to these diseases. We are testing that right now."

More information

The Crohn's and Colitis Foundation of America has more about inflammatory bowel disease.

-- Robert Preidt

SOURCE: University of Chicago Medical Center, news release, June 12, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Belly Membrane May Regulate Immune System, Mouse Study Finds
2. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
3. This mousetrap may save lives
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Heavy Drinking, Smoking Wont Harm Mens Sperm: Study
6. Sleep Habits in U.S. Vary by Race, Native Country: Study
7. Study finds Massachusetts health reform leads to increased inpatient surgical procedures
8. Study finds socioeconomic status linked to weight gain and risk of obesity in African-American women
9. Huge Rise in CT, MRI, Ultrasound Scan Use: Study
10. Mindful Meditation Tied to Healthy Brain Changes: Study
11. Female Doctors Earn Less Than Male Counterparts: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis
(Date:12/2/2016)... ... December 02, 2016 , ... More than 100 business, ... expected to attend the UNCF Dothan-Wiregrass Mayor’s Luncheon Dec. 9, 2016. This inaugural ... students and operating support to UNCF-member institutions, including Miles College, Oakwood University, Tuskegee ...
(Date:12/2/2016)... ... 2016 , ... FlexiSpot, a trusted name in sit-stand solutions ... for all of the company’s desktop riser products. A simple application form and ... FlexiSpot’s unique desktop risers use an advanced dual gas spring hovering system to ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... The annual ... Enrollment Period (or Annual Election Period), is ending December 7th. Currently-enrolled Medicare beneficiaries who ... C) or prescription drug plan (Part D) need to make changes during this period ...
(Date:12/2/2016)... ... December 02, 2016 , ... With the number of pain management programs ... patients must find the one that works for them. When an inventor from Suisun ... that worked and decided to share it with others. , He developed a prototype ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. ... will be included in the 2016 “Guide to America’s Top Plastic Surgeons” for ... the amalgamation of their education, experience, and professional associations. , One the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- On Thursday, the NASDAQ Composite and the ... Dow Jones Industrial Average managed to stay in green. Losses ... prompted Stock-callers this morning to look at the performances of ... ), Smith & Nephew PLC (NYSE: SNN ), ... Therapeutics Inc. (NASDAQ: KOOL ). You can access ...
(Date:12/2/2016)... 2016 Research and Markets has announced ... Cancer - Technologies, Markets and Companies" to their offering. ... , , ... cancer The market value of drug delivery technologies and ... 2015-2025 are given according to organs involved and the types of ...
(Date:12/2/2016)... Conn. , Dec. 1, 2016  Today, Simpson ... announced the honor of being selected as winners of ... Simpson Healthcare Executives Website at the PLATINUM level, Blue ... Training Module at the GOLD Level, and our proprietary ... At Simpson Healthcare Executives, we are excited to ...
Breaking Medicine Technology: