Navigation Links
Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis
Date:6/13/2012

WEDNESDAY, June 13 (HealthDay News) -- Certain types of saturated fats common in today's Western diet may change gut bacteria and trigger inflammatory bowel disease in people genetically predisposed to the disorder, according to a new study that looked at this relationship in mice.

Inflammatory bowel disease includes ulcerative colitis and Crohn's disease.

The University of Chicago researchers said their findings help explain why once rare immune-system-related disorders such as inflammatory bowel disease have become more common in the United States and other Westernized nations in the last half-century.

The researchers said their study may shed some light on why many people who are genetically prone to the condition still don't develop it and how certain environmental factors can cause inflammation in those at risk.

Scientists note, however, that research with animals often fails to provide similar results in humans.

Working with mice with characteristics of human inflammatory bowel disease, the researchers found that concentrated milk fats alter the composition of bacteria in the intestines. These changes can alter the fragile truce between the immune system and the complex but largely beneficial mix of bacteria in the intestines.

Harmful bacteria can trigger an unregulated tissue-damaging immune-system response that can be difficult to turn off, according to the study published online June 13 in the journal Nature.

Concentrated milk fats are used widely in processed and confectionary foods, the researchers noted.

The same response was not seen with polyunsaturated fats, which are found in plant-based foods and oils.

"This is the first plausible mechanism showing step by step how Western-style diets contribute to the rapid and ongoing increase in the incidence of inflammatory bowel disease," study author Dr. Eugene Chang, a professor of medicine at the University of Chicago, said in a university news release.

"We know how certain genetic differences can increase the risk for these diseases, but moving from elevated risk to the development of disease seems to require a second event that may be encountered because of our changing lifestyle," he said.

Not much can be done to correct genes that increase a person's risk for inflammatory bowel disease, and getting people to change their diets is often difficult and seldom effective, Chang said.

"However, the balance between host and microbes can be altered back to a healthy state to prevent or treat these diseases," he added. "In essence, the gut microbiome can be 'reshaped' in ... ways that restore a healthy relationship between host and microbes, without significantly affecting the lifestyles of individuals who are genetically prone to these diseases. We are testing that right now."

More information

The Crohn's and Colitis Foundation of America has more about inflammatory bowel disease.

-- Robert Preidt

SOURCE: University of Chicago Medical Center, news release, June 12, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Belly Membrane May Regulate Immune System, Mouse Study Finds
2. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
3. This mousetrap may save lives
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Heavy Drinking, Smoking Wont Harm Mens Sperm: Study
6. Sleep Habits in U.S. Vary by Race, Native Country: Study
7. Study finds Massachusetts health reform leads to increased inpatient surgical procedures
8. Study finds socioeconomic status linked to weight gain and risk of obesity in African-American women
9. Huge Rise in CT, MRI, Ultrasound Scan Use: Study
10. Mindful Meditation Tied to Healthy Brain Changes: Study
11. Female Doctors Earn Less Than Male Counterparts: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Suggests Certain Fats Could Trigger Crohn's, Colitis
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
Breaking Medicine Technology: