Navigation Links
Mouse Study Suggests Brain Is Damaged Early in Lou Gehrig's Disease
Date:11/12/2014

TUESDAY, Nov. 11, 2014 (HealthDay News) -- Muscle-controlling nerve cells in the brain may be damaged earlier in Lou Gehrig's disease than previously thought, a new mouse study suggests.

The findings may lead researchers to shift their focus on the origins of the neurological disease -- also called amyotrophic lateral sclerosis (ALS) -- from the spinal cord to the brain's motor cortex, according to the researchers from Cedars-Sinai Medical Center's Regenerative Medicine Institute in Los Angeles.

ALS is an invariably fatal disease that causes muscle weakness, paralysis and, ultimately, respiratory failure.

"In this study, we show the exact progression of ALS in animals that have an inherited form of the disease, and we expose the brain's significant role in initiating the disease process thought previously to originate in the muscle or spinal cord," study senior author and institute director Clive Svendsen, said in a Cedars-Sinai news release.

"We did this by selectively removing the disease-causing mutation just from the brains of ALS animals, and found that this alone had a big impact on disease initiation and progression," he added.

The study was published Nov. 12 in the Journal of Neuroscience.

"We found that spinal motor neurons [nerve cells that control muscles] die before symptoms begin and before nerve damage occurs between the spinal cord and the muscles," Svendsen said.

"In fact, motor neuron death starts in the spinal cord and radiates out to the muscle and the brain over time," he explained. "Motor neurons in the brain are not lost until the final stages of the disease, but starting very early in the process they appear to exist in a dysfunctional form."

"When we suppressed the ALS mutation in the brains of animals, onset of the disease was delayed, the animals lived longer, spinal motor neurons survived longer, and the neuromuscular junctions stayed healthy longer," he added.

Study first author Gretchen Thomsen, a scientist in Svendsen's laboratory, added that, "It is likely that dysfunction at a cellular level, without cell death, goes undetected for years prior to symptom onset and clinical diagnosis."

"It is imperative that we identify patients at high risk of developing ALS and devise and initiate treatments that can intervene before an irreversible cascade of motor neuron circuitry failure sets in," Thomsen added.

Scientists note that research involving animals often fails to produce similar results in humans.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about amyotrophic lateral sclerosis.

SOURCE: Cedars-Sinai Medical Center, news release, Nov. 11, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. First mouse model for ALS dementia
2. XenOPAT, mouse models for personalized cancer treatment
3. Mouse model sheds light on role of mitochondria in neurodegenerative diseases
4. Targeted immune booster removes toxic proteins in mouse model of Alzheimers disease
5. Researchers define a spontaneous retinal neovascular mouse model
6. Mouse studies advance treatment for common eye diseases
7. Mouse model for epilepsy, Alzheimers gives window into the working brain
8. New mouse model points to therapy for liver disease
9. Potential drug therapy for kidney stones identified in mouse study
10. Insular cortex alterations in mouse models of autism
11. Supermodel mouse reveals mechanisms that regulate metabolism, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/11/2020)... ... August 11, 2020 , ... ... is offering a new line of sanitizers that are fragrance-free and gentle on ... have an unpleasant odor or potentially dangerous levels of toxic chemicals. This is ...
(Date:8/9/2020)... ... 2020 , ... Dr. Angela Abraham has been appointed as the first-ever Diversity ... be leading the drive to foster a more equitable and bias-free NECO community. , ... new initiative led by Black Eyecare Perspective and dedicated to increasing Black presence in ...
(Date:8/7/2020)... ROSEMONT, Ill. (PRWEB) , ... August 07, 2020 ... ... Medicaid Services (CMS) released the Physician Fee Schedule proposed rule for the 2021 ... care professional teams by devaluing the procedures they perform which help return patients ...
(Date:8/5/2020)... ... August 05, 2020 , ... AdventHealth Carrollwood has partnered with Bayshore Christian ... on Monday, August 12, 2020. AdventHealth provided the school with key strategies and implementation ... classroom setting. , “We are taking extra steps in our hospital and in ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... health industry, as president of the largest veterinarian-owned purchasing Cooperative in the United ... in various roles where she gained extensive knowledge and experience in the animal ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... August 04, 2020 , ... In an informal poll of ... majority voted for a refreshed Minnesota Twins “Minnie and Paul” logo that is more ... circa 1960. That was well before the civil rights movement in the United States. ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... COVID-19, An FDAnews Webinar, Wednesday, Aug. 19, 2020, 1:30 p.m.-3:00 p.m. EDT, ... never simple and COVID-19 has made it more challenging. From COVID-19 monitoring ...
(Date:8/3/2020)... ... , ... LaVoieHealthScience (LHS), an integrated investor and public relations consulting ... President, CEO and Founder of LHS, has been named to the PharmaVOICE 100 ... 100 has honored more than 1,500 industry executives for their contributions to the life ...
Breaking Medicine Technology: