Navigation Links
Mouse Study Suggests Alzheimer's Spreads Through Brain Like an Infection
Date:2/2/2012

By Margaret Farley Steele and Steven Reinberg
HealthDay Reporters

THURSDAY, Feb. 2 (HealthDay News) -- Alzheimer's disease appears to spread through the brain, traveling from neuron to neuron in much the same way that an infection or cancer moves through the body, new research with mice suggests.

Scientists reported Thursday that their work indicates that abnormal tau protein -- already identified in the brains of those with Alzheimer's -- starts in one region of the brain and spreads along linked cellular circuits.

Identification of this tau pathway could influence the direction of future research and treatment of the mind-wasting disease, the study authors and other experts said.

"This opens up a whole new area of biology that has direct relevance for Alzheimer's disease. We now have a whole new set of targets that perhaps we can develop drugs for," said study lead author Karen Duff, a professor of pathology at Columbia University's Taub Institute for Research on Alzheimer's Disease and the Aging Brain.

The process was first noticed in autopsies of Alzheimer's patients where one could see the disease's path from one cell to another. The researchers behind the new study created genetically engineered mice to mimic that disease process.

"Now we have this protein going outside a cell and into another cell, so we potentially have something we can target with drugs," Duff said. "This is a very early aspect of the disease. Once this protein starts to move around the brain it can spread very rapidly."

This is a process that seems to happen in all types of Alzheimer's cases, she said.

One idea for a treatment would be to develop a therapeutic vaccine that could stop this process in its tracks early before dementia sets in, Duff said.

However, far more research is needed into the new findings before they might yield any therapeutic benefit to people, experts said.

Dr. Sam Gand
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Mouse Study Give Clues to Why Exercise Is Healthy
2. Gene expression in mouse neural retina sequenced
3. UGA researchers develop first mouse model to study important aspect of Alzheimer’s
4. Drinking Patterns Affect Heart Health, Mouse Study Finds
5. Mouse Study Could Give New Clues to Fighting Baldness
6. New mouse model for testing cancer drugs
7. Human Stem Cells Used to Fix Damaged Mouse Heart
8. Mouse Study Uncovers the Roots of Gray Hair
9. Mouse Study Reveals How Smoking Helps Keep People Thin
10. Apples Help Keep Muscles Strong, Mouse Study Finds
11. Scientists create humanized mouse model for hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/5/2015)... ... July 05, 2015 , ... Doctors at the Swedish Cancer Institute in ... one day change the outlook for people with pleural mesothelioma. Surviving Mesothelioma has just ... Researchers report that five mesothelioma patients treated with 25Gy of radiation over five days ...
(Date:7/4/2015)... ... 2015 , ... When a hacker gains access to someone’s email account, it can lead to ... July 1st, the FTC issued a scam alert about a social engineering scam ... a password reset instigated by the hacker. All they have to do is click ...
(Date:7/3/2015)... ... , ... On June 30th SEO authority and veteran Internet ... "Page One Engine" . The program, which has been hailed as the ... well-known marketers. HonestyFirstReviews.com's Tiffany Hendricks has joined the party, publishing an in-depth review ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. ... has been retained to lead a national president recruitment for Regional ... the healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare ...
(Date:7/3/2015)... Louis, MO (PRWEB) , ... July 03, 2015 , ... ... responsive website to replace their existing Talcum Powder Cancer Lawsuit Center website. Just as ... talcum powder lawsuit news , offering timely lawsuit updates and ovarian cancer warning ...
Breaking Medicine News(10 mins):Health News:New Mesothelioma Study Calls IMRT/Surgery Combo “Innovative and Promising”, According to Surviving Mesothelioma 2Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 2Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 3Health News:New FTC Scam Alert Shows Latest Example of Social Engineering Dangers 4Health News:Page One Engine - Review Of Dori Friend's SEO Training Course Released 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3
... CMS Training Program,To Address Federal Regulator’s New Marketing Compliance Guidelines ... ... 8, 2008 -- Connextions Inc. announced today that ... intensive training program for its in-house licensed insurance agents in ...
... Growing Number of Measures Helping Those Suffering,from Mental Illness, ... making it,easier for someone with a severe mental illness ... Governor Bobby Jindal on,June 21, 2008. The law, which ... year, will take effect on August 15., "Nicola,s ...
... Need for Parents to Include Life Insurance ... in Their College-Funding Plans, ARLINGTON, ... -- turns. When a loved one dies, it can be particularly,painful. ... that comes when the head of the household dies,prematurely with little ...
... people suffer from preventable, treatable diseases around,the world, ... Global Health Progress, TOYAKO, Japan, July 8 ... Health Organization (WHO) and,the Drugs for Neglected Diseases ... the importance of neglected diseases as a global ...
... An economist examining the,proposed merger of Highmark, Inc. ... companies would have a market share far greater,than ... presented to the,Pennsylvania Insurance Department today in Pittsburgh ... International, the proposed merger,would result in a combined ...
... the most complex and challenging mental disorder in the ... and longterm treatment needs and may be associated in ... burden for both the individual and family. It is ... clinically severe mood disorder. The disorder is called bipolar, ...
Cached Medicine News:Health News:Connextions Inc. Works to Ensure CMS Compliance for Medicare Advantage Plan Providers 2Health News:Connextions Inc. Works to Ensure CMS Compliance for Medicare Advantage Plan Providers 3Health News:Louisiana Improves Law for Treating Mentally Ill 2Health News:LIFE Foundation Asks Public to Vote to Determine its $5,000 Life Lessons College Scholarship Winner 2Health News:LIFE Foundation Asks Public to Vote to Determine its $5,000 Life Lessons College Scholarship Winner 3Health News:Global Health Progress Joins WHO and DNDi to Call For Increased Commitments to Fighting Neglected Tropical Diseases 2Health News:Economist Finds Highmark/IBC Merger Would Result in 70 Percent Share in Pennsylvania, Far Higher Than Initial Reports 2Health News:The ECNP consensus statement on bipolar depression 2
(Date:7/2/2015)... SAN DIEGO , July 2, 2015 ResMed ... report its fourth quarter and fiscal year ended June 30, ... York Stock Exchange market close. A press release with ResMed,s ... and the company will host a webcast to discuss operating ... scheduled to begin at 1:30 p.m. US Pacific Time and ...
(Date:7/2/2015)... 2, 2015  Before you head outdoors with your family ... stay safe and healthy. Take steps to protect yourself from ... Protect Your Skin From the Sun ... increase your risk of skin cancer. To protect your skin ... possible, especially during midday hours. Wear a hat with a ...
(Date:7/2/2015)... According to a new market research report " ... Stimulation, Transcranial Magnetic Stimulation), Application (Depression, Parkinson,s, Tinnitus, Alzheimer,s, Epilepsy, ... MarketsandMarkets, the global Neuromodulation Market is estimated at $3.65 Billion ... 2020, at a CAGR of 11.2% during the forecast period. ... market data T ables and 32 ...
Breaking Medicine Technology:ResMed to Announce Fourth Quarter and Fiscal Year-End 2015 Results 2First Aid Summer Survival Tips from Nyack Hospital 2First Aid Summer Survival Tips from Nyack Hospital 3Neuromodulation Market Worth $6.20 Billion by 2020 2Neuromodulation Market Worth $6.20 Billion by 2020 3Neuromodulation Market Worth $6.20 Billion by 2020 4
... Phase 1,clinical trial results for NKTR-118 (oral PEG-naloxol) were ... at the Annual Meeting of the,American Pain Society (APS) ... NKTR-118 was shown to have substantial oral bioavailability,with rapid ... ten times the,known half-life of unPEGylated naloxone., NKTR-118 ...
... Shows Benefits Differ from those in Adults-, ... are hospitalized for bacterial meningitis do not provide ... according to a large,multicenter study by pediatric researchers. ... hospitalized adults, for whom corticosteroids,dramatically reduced mortality., ...
Cached Medicine Technology:NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting 2NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting 3NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting 4NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting 5NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting 6Steroids Provide No Survival Benefit for Children With Bacterial Meningitis 2Steroids Provide No Survival Benefit for Children With Bacterial Meningitis 3
Tube for Right Bronchus - Ruschelit™ PVC. Color coded for easy identification of ports, balloons and 15mm connectors. High volume/low pressure cuffs. With Carina hook. X-ray opaque line. Gradua...
... For Laryngotracheal Instillation of Topical ... adult populations, this cuffed tube incorporates ... for spray application of topical anesthetic ... ,SHERIDAN offers three endotracheal tubes designs ...
SPIRAL-FLEX® Reinforced Oral/Nasal Uncuffed Endotracheal Tubes...
... ,Designed for neonatal and pediatric ... incorporates a monitoring lumen within the ... to the distal tip. Luer lock ... convenient connection for CO2 monitoring, pressure ...
Medicine Products: