Navigation Links
Mouse Study Reveals a Cancer Cell Escape Route
Date:10/29/2010

FRIDAY, Oct. 29 (HealthDay News) -- Research in mice reveals that a small number of cancer cells escape from chemotherapy by hiding out in the thymus, the organ where immune cells mature.

While in the thymus, the cancer cells are covered in growth factors that protect them from the effects of chemotherapy drugs. These cancer cells later cause tumor relapse, said the Massachusetts Institute of Technology (MIT) biologists.

The study findings are published in the Oct. 29 issue of the journal Cell.

The MIT team plans to conduct tests, in mice, of drugs that interfere with one of those protective growth factors. Using these drugs in combination with chemotherapy could offer a one-two punch that eliminates tumor cells and prevents relapse, they suggest.

"Successful cancer therapy needs to involve a component that kills tumor cells as well as a component that blocks pro-survival signals. Current cancer therapies fail to target this survival response," study leader Michael Hemann, an assistant professor of biology, said in an MIT news release.

While he and his colleagues found that cancer cells seek refuge in the thymus, they believe there may be other places in the body, such as bone marrow, where cancer cells are protected from chemotherapy.

It's not known whether the findings will translate to human patients, but they do suggest several targets for investigation, researchers said.

More information

The U.S. National Cancer Institute has more about chemotherapy.

-- Robert Preidt

SOURCE: Massachusetts Institute of Technology, news release, Oct. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Mouse Study May Help Explain Fish Oils Benefits
2. Treatment for S. aureus skin infection works in mouse model
3. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
4. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
5. Fat in Males, Females Differs Genetically, Mouse Study Shows
6. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
7. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
8. Dxtra Introduces New Solid Stainless Steel Mouse Pad
9. NIA researchers find gene to explain mouse embryonic stem cell immortality
10. Rapamycin rescues learning, memory in Alzheimers mouse model
11. Many Parents in the Dark About Drug-Resistant Infections: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Reveals a Cancer Cell Escape Route
(Date:8/22/2017)... ... ... Star Glass is new to the Texas market, but is proudly managed by widely recognized ... and models, in Grand Prairie, TX, located in the center of the DFW Metroplex, the ... business for the past 40 years with 32 convenient locations in Texas, Nevada and California ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert Awakening”: ... creation of published author, Julianne Hale, a consultant for the Intelligence Community. ... expert focusing on the Near East region. Julianne has written hundreds of ...
(Date:8/22/2017)... ... 22, 2017 , ... “Call Of Spiritual Duty”: a revelation in an era ... C.S. Lizarde. Growing up on the streets of North Visalia, California, Carlos Lizarde ... apply the Biblical keys to his life, he noticed immediately that opportunities and blessings ...
(Date:8/21/2017)... ... August 22, 2017 , ... The ... as a 2017-2018 inductee into its VIP Woman of the Year Circle. She ... nation’s leading networking organization exclusively for professional women, boasting more than 850,000 members, ...
(Date:8/21/2017)... , ... August 21, 2017 , ... Five chefs from ... awareness for Alzheimer’s Family Center. , Guests will be able to vote for ... Plaza, Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce & Garlic Pita ...
Breaking Medicine News(10 mins):
(Date:8/14/2017)... Israel , Aug. 15, 2017 /PRNewswire/ ... of adult stem cell technologies for neurodegenerative diseases, announced ... 2017. "We are ... Phase 3 trial to investigate NurOwn ® in ... Executive Officer of BrainStorm. "We have agreements with Mass. ...
(Date:8/10/2017)... , Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired ... Lakewood, Colorado . The reputable clinic will ... , PT, DPT with his staff of four clinicians. Lipkin ... Pittsburgh and brings over 10 years of experience with a ... Belmar PT marks the 10th PRN clinic in and around ...
(Date:8/8/2017)...   Second-quarter 2017 revenues of ... share from continuing operations ... to $110 million Second-quarter ... million Second-quarter 2017 adjusted ... 8 percent to $0.93 ...
Breaking Medicine Technology: