Navigation Links
Mouse Study Reveals a Cancer Cell Escape Route
Date:10/29/2010

FRIDAY, Oct. 29 (HealthDay News) -- Research in mice reveals that a small number of cancer cells escape from chemotherapy by hiding out in the thymus, the organ where immune cells mature.

While in the thymus, the cancer cells are covered in growth factors that protect them from the effects of chemotherapy drugs. These cancer cells later cause tumor relapse, said the Massachusetts Institute of Technology (MIT) biologists.

The study findings are published in the Oct. 29 issue of the journal Cell.

The MIT team plans to conduct tests, in mice, of drugs that interfere with one of those protective growth factors. Using these drugs in combination with chemotherapy could offer a one-two punch that eliminates tumor cells and prevents relapse, they suggest.

"Successful cancer therapy needs to involve a component that kills tumor cells as well as a component that blocks pro-survival signals. Current cancer therapies fail to target this survival response," study leader Michael Hemann, an assistant professor of biology, said in an MIT news release.

While he and his colleagues found that cancer cells seek refuge in the thymus, they believe there may be other places in the body, such as bone marrow, where cancer cells are protected from chemotherapy.

It's not known whether the findings will translate to human patients, but they do suggest several targets for investigation, researchers said.

More information

The U.S. National Cancer Institute has more about chemotherapy.

-- Robert Preidt

SOURCE: Massachusetts Institute of Technology, news release, Oct. 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Mouse Study May Help Explain Fish Oils Benefits
2. Treatment for S. aureus skin infection works in mouse model
3. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
4. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
5. Fat in Males, Females Differs Genetically, Mouse Study Shows
6. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
7. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
8. Dxtra Introduces New Solid Stainless Steel Mouse Pad
9. NIA researchers find gene to explain mouse embryonic stem cell immortality
10. Rapamycin rescues learning, memory in Alzheimers mouse model
11. Many Parents in the Dark About Drug-Resistant Infections: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Reveals a Cancer Cell Escape Route
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: