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Mouse Study Reveals How Smoking Helps Keep People Thin
Date:6/9/2011

By Amanda Gardner
HealthDay Reporter

THURSDAY, June 9 (HealthDay News) -- The notion that smoking somehow helps keep smokers thin has gotten new support from a study in mice -- and the finding might one day be parlayed into new drugs to control weight gain.

It's always a leap to extrapolate from animal experiments, one expert said, but this new research does open up interesting possibilities.

"Humans have basically the receptors as mice," noted Ursula Winzer-Serhan, an associate professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine in Bryan. "There is good evidence that what happens in mice also happens in humans."

Winzer-Serhan was not involved with the study, which appears in the June 10 issue of Science.

"We have to be very cautious," added study author Yann Mineur, but the basic biology, "as far as we can tell, is fairly similar to what's happening in humans."

It's well known that people who smoke tend to be skinnier, even if their lives tend to be shorter than those of nonsmokers.

"All animal studies show that nicotine reduces body weight by reducing food intake and increasing energy expenditure," said Winzer-Serhan. "That is one of the few facts in science there is not a lot of controversy about."

But the new study goes deeper than that. Mineur, an associate research scientist in psychiatry at Yale School of Medicine, stumbled upon the compound used in the study, cytisine, while looking into possible drugs for depression.

The smoking-cessation drug Chantix (varenicline) is a derivative of cytisine.

In experiments with mice, cytisine prevented weight gain by activating the same set of neurons in the hypothalamus as nicotine does. This neurological pathway is also involved in appetite and metabolism, the researchers said.

However, even though the idea of targeting nicotine receptors to control w
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