Navigation Links
Mouse Study Reveals How Smoking Helps Keep People Thin
Date:6/9/2011

By Amanda Gardner
HealthDay Reporter

THURSDAY, June 9 (HealthDay News) -- The notion that smoking somehow helps keep smokers thin has gotten new support from a study in mice -- and the finding might one day be parlayed into new drugs to control weight gain.

It's always a leap to extrapolate from animal experiments, one expert said, but this new research does open up interesting possibilities.

"Humans have basically the receptors as mice," noted Ursula Winzer-Serhan, an associate professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine in Bryan. "There is good evidence that what happens in mice also happens in humans."

Winzer-Serhan was not involved with the study, which appears in the June 10 issue of Science.

"We have to be very cautious," added study author Yann Mineur, but the basic biology, "as far as we can tell, is fairly similar to what's happening in humans."

It's well known that people who smoke tend to be skinnier, even if their lives tend to be shorter than those of nonsmokers.

"All animal studies show that nicotine reduces body weight by reducing food intake and increasing energy expenditure," said Winzer-Serhan. "That is one of the few facts in science there is not a lot of controversy about."

But the new study goes deeper than that. Mineur, an associate research scientist in psychiatry at Yale School of Medicine, stumbled upon the compound used in the study, cytisine, while looking into possible drugs for depression.

The smoking-cessation drug Chantix (varenicline) is a derivative of cytisine.

In experiments with mice, cytisine prevented weight gain by activating the same set of neurons in the hypothalamus as nicotine does. This neurological pathway is also involved in appetite and metabolism, the researchers said.

However, even though the idea of targeting nicotine receptors to control weight has been around a long time, the problem is that nicotine receptors are located all over the body, explained William Tank, chair of pharmacology and physiology at the University of Rochester Medical Center.

That means that any drug developed to control weight via nicotinic receptors would have to be very targeted, otherwise it could have effects on other parts of the body, including memory, blood pressure and heart beat, explained Winzer-Serhan.

Cytisine, which Mineur says is already used in some Eastern European countries as a smoking-cessation aid, is fairly selective, targeting receptors in the peripheral nervous system.

In the meantime, the current findings should not be used to encourage smoking as a weight-loss tool, given the habit's deadly effects.

Certain nicotine-based, smoking-cessation techniques, such as patches, could potentially limit weight gain, Mineur says, but smoking is not the way to go.

Mineur also pointed out that there are many other factors associated with post-smoking weight gain, such as munching on candy because you miss the cigarette.

"The idea of there being a therapeutic use of nicotine agonists is . . . a great idea," said Tank. "[But] this is a very complicated set of physiologies and nicotine is an extraordinarily complicated drug."

More information

For help on quitting smoking, head to the American Lung Association.

SOURCES: Yann Mineur, Ph.D., associate research scientist in psychiatry, Yale School of Medicine, New Haven, Conn.; William Tank, Ph.D., professor and chair, pharmacology and physiology, University of Rochester Medical Center; Ursula Winzer-Serhan, Ph.D., associate professor, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine, Bryan; June 10, 2011, Science


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Apples Help Keep Muscles Strong, Mouse Study Finds
2. Scientists create humanized mouse model for hepatitis C
3. Pitt researchers build a better mouse model to study depression
4. Mouse study turns fat-loss/longevity link on its head
5. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
6. Sleeping through danger: the dormouse approach to survival
7. Mouse Sperm Successfully Grown in Lab, Researchers Say
8. Mouse cancer genome unveils genetic errors in human cancers
9. Malaria drug slows pancreatic cancer growth in mouse models
10. New mouse model explains common pediatric brain tumor
11. Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Reveals How Smoking Helps Keep People Thin
(Date:4/29/2016)... , ... April 29, 2016 , ... Spine Team Texas, ... is proud to announce one of their physicians has been invited to be a ... (Texas ACOFP) Family Practice Review conference on April 30, 2016. , Dr. R. ...
(Date:4/29/2016)... New York, NY (PRWEB) , ... April 29, ... ... integrated manufacturer and engineer of patented products, announces the Gyrociser, an exercise invention ... industry is worth $2 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:4/29/2016)... ... , ... Dr. Robert Mondavi, one of the dentists in Torrance , ... fast-growing field as more patients are discovering the many different ways they can change ... currently available to them and which ones might work for their smiles. , ...
(Date:4/29/2016)... ... , ... For those who skip meals occasionally (which is pretty much everyone), ... many new lifestyle diet tips offered by nutritionists Pam Bonney and Priya Lawrence of ... show. Bonny and Lawrence noted that because proper nutrition, including water, provides energy during ...
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 ... survey, earning them second place for Tampa’s Best Places to Work. They were ranked ... is a great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
(Date:4/28/2016)... 28, 2016   Click here for supplemental ... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, ... agreement to acquire Valley Campus Pharmacy, Inc., doing ... leading specialty pharmacy that provides individualized patient care, ... . In 2015, TNH generated approximately $400 million ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: