Navigation Links
Mouse Study Reveals How Smoking Helps Keep People Thin
Date:6/9/2011

By Amanda Gardner
HealthDay Reporter

THURSDAY, June 9 (HealthDay News) -- The notion that smoking somehow helps keep smokers thin has gotten new support from a study in mice -- and the finding might one day be parlayed into new drugs to control weight gain.

It's always a leap to extrapolate from animal experiments, one expert said, but this new research does open up interesting possibilities.

"Humans have basically the receptors as mice," noted Ursula Winzer-Serhan, an associate professor of neuroscience and experimental therapeutics at the Texas A&M Health Science Center College of Medicine in Bryan. "There is good evidence that what happens in mice also happens in humans."

Winzer-Serhan was not involved with the study, which appears in the June 10 issue of Science.

"We have to be very cautious," added study author Yann Mineur, but the basic biology, "as far as we can tell, is fairly similar to what's happening in humans."

It's well known that people who smoke tend to be skinnier, even if their lives tend to be shorter than those of nonsmokers.

"All animal studies show that nicotine reduces body weight by reducing food intake and increasing energy expenditure," said Winzer-Serhan. "That is one of the few facts in science there is not a lot of controversy about."

But the new study goes deeper than that. Mineur, an associate research scientist in psychiatry at Yale School of Medicine, stumbled upon the compound used in the study, cytisine, while looking into possible drugs for depression.

The smoking-cessation drug Chantix (varenicline) is a derivative of cytisine.

In experiments with mice, cytisine prevented weight gain by activating the same set of neurons in the hypothalamus as nicotine does. This neurological pathway is also involved in appetite and metabolism, the researchers said.

However, even though the idea of targeting nicotine receptors to control weight has been around a long time, the problem is that nicotine receptors are located all over the body, explained William Tank, chair of pharmacology and physiology at the University of Rochester Medical Center.

That means that any drug developed to control weight via nicotinic receptors would have to be very targeted, otherwise it could have effects on other parts of the body, including memory, blood pressure and heart beat, explained Winzer-Serhan.

Cytisine, which Mineur says is already used in some Eastern European countries as a smoking-cessation aid, is fairly selective, targeting receptors in the peripheral nervous system.

In the meantime, the current findings should not be used to encourage smoking as a weight-loss tool, given the habit's deadly effects.

Certain nicotine-based, smoking-cessation techniques, such as patches, could potentially limit weight gain, Mineur says, but smoking is not the way to go.

Mineur also pointed out that there are many other factors associated with post-smoking weight gain, such as munching on candy because you miss the cigarette.

"The idea of there being a therapeutic use of nicotine agonists is . . . a great idea," said Tank. "[But] this is a very complicated set of physiologies and nicotine is an extraordinarily complicated drug."

More information

For help on quitting smoking, head to the American Lung Association.

SOURCES: Yann Mineur, Ph.D., associate research scientist in psychiatry, Yale School of Medicine, New Haven, Conn.; William Tank, Ph.D., professor and chair, pharmacology and physiology, University of Rochester Medical Center; Ursula Winzer-Serhan, Ph.D., associate professor, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine, Bryan; June 10, 2011, Science


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Apples Help Keep Muscles Strong, Mouse Study Finds
2. Scientists create humanized mouse model for hepatitis C
3. Pitt researchers build a better mouse model to study depression
4. Mouse study turns fat-loss/longevity link on its head
5. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
6. Sleeping through danger: the dormouse approach to survival
7. Mouse Sperm Successfully Grown in Lab, Researchers Say
8. Mouse cancer genome unveils genetic errors in human cancers
9. Malaria drug slows pancreatic cancer growth in mouse models
10. New mouse model explains common pediatric brain tumor
11. Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Reveals How Smoking Helps Keep People Thin
(Date:4/26/2017)... ... 26, 2017 , ... RawTrition now brings you BioEnergy which is a powder ... , RawTrition is taking nutrients to the next level! The superfoods ... its raw form (unlike the synthetically made options that are on the market). , ...
(Date:4/25/2017)... ... ... Bellus Medical, a leader in medical aesthetics, recently acquired ... photodynamic cosmetics (PDC). , Allumera® is the first PDC cream specifically formulated to ... minimize the appearance of pores – all with minimal downtime and results that ...
(Date:4/25/2017)... IN (PRWEB) , ... April 25, 2017 , ... ... D.C., CEOs, CFOs and HR decision-makers are preparing for how his administration could ... Financial will provide insight into what changes are most likely to make it ...
(Date:4/25/2017)... Switzerland (PRWEB) , ... April 25, 2017 , ... ... innovation targets, they rely on contracted partners to help with process innovation in ... of combined drug formulation experience along with state-of-the-art analytical equipment in support of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Somnoware, a leading ... patient care management module. Using this new feature, sleep physicians can now predict ... on continuous positive airway pressure (CPAP), oral, or other forms of sleep apnea ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 NeuroVive Pharmaceutical ... today announced positive preclinical results demonstrating anti-fibrotic ... for non-alcoholic steatohepatitis (NASH), in an additional ... NV556 has previously shown similar anti-fibrotic ... Today, NeuroVive,s scientists present novel data demonstrating ...
(Date:4/19/2017)... -- Cardiology devices segment is anticipated to reach the highest ... Devices segment is likely to create absolute $ opportunity of ... 2017. By the end of 2027, Cardiology Devices segment is ... Mn, expanding at a CAGR of 18.4% over the forecast ... Pacific reprocessed medical devices market in terms of ...
(Date:4/19/2017)... , April 19, 2017 Global Surgical Drainage ... are tubes used to remove excess liquid and air. ... pus, urine, bile or lymph. Surgical drains are used ... such as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery ... post-surgery to prevent accumulation of fluid e.g. blood or ...
Breaking Medicine Technology: