Navigation Links
Mouse Study May Advance Multiple Sclerosis Research
Date:1/19/2010

Gene mutation in mice causes problems similar to MS in humans, findings show

TUESDAY, Jan. 19 (HealthDay News) -- A mutation in a gene called ZFP191 causes central nervous system myelination problems in mice that are similar to what occurs in humans with multiple sclerosis, new research has found.

In multiple sclerosis, an autoimmune disorder, the body attacks and destroys the myelin sheath that insulates and protects nerve fibers of the central nervous system (brain, spinal cord and optic nerves). Symptoms range from tingling and numbness in limbs to loss of vision and paralysis. The condition affects about 400,000 people in the United States and about 2.5 million people worldwide.

In the new study, Brian Popko of the University of Chicago and colleagues determined that a gene called ZFP191 is necessary for the development of oligodendrocyte cells, which, in their fully mature form, produce myelin. The researchers also found that mice with a single mutation in ZFP191 have a severe deficiency in central nervous system myelination and suffer tremors and seizures.

According to the study, published in the Feb. 1 issue of the journal Genes & Development, the findings may help in efforts to develop ways to promote re-myelination, reduce the accumulation of multiple sclerosis lesions and slow disease progression.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about multiple sclerosis.



-- Robert Preidt



SOURCE: Cold Spring Harbor Laboratory, news release, Jan. 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

0

GOOD

Page: 1

Related medicine news :

1. Schizophrenia mouse model should improve understanding and treatment of the disorder
2. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
3. How diarrheal bacteria cause some colon cancers revealed in mouse studies
4. Instant Demo Screen Recorder Now With TrakMouse™ Technology
5. Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
6. Stem cell transplant in mouse embryo yields heart protection in adulthood
7. Astrocytes help separate man from mouse
8. Mouse Study Suggests ADHD Drug Might Be Addictive
9. Living with females extends the reproductive life of the male mouse, says Penn veterinary researcher
10. Cosmetic Surgery -Goldilocks Anesthesia Is Not Mickey Mouse
11. Common anesthetic induces Alzheimers-associated changes in mouse brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... California (PRWEB) May 18, 2013 Also ... is an increasingly popular weight loss surgery that guarantees ... Lap Band Center wishes to give readers a ... Dr. Naim attended medical school at New York City’s ... New York Methodist he undertook a fellowship in Minimally ...
(Date:5/18/2013)... 18, 2013 Online watch retailer Time and ... watch owners at a fraction of its usual cost. ... in the world, buyers are urged to take advantage of ... a Rolex watch from a brick-and-mortar store, buyers now have ... watches priced at unbelievable rates. Although some buyers may have ...
(Date:5/18/2013)... (PRWEB) May 19, 2013 Illuminations is proud ... Trisha Caetano. Seminars will take place over the course ... Friday, June 7, and Saturday, June 8, 2013. , Inner ... symptoms, but focuses on the attitudes, patterns and coping mechanisms ... symptoms. Participants will learn to live a more integrated and ...
(Date:5/18/2013)... Dennis Thompson HealthDay Reporter , , FRIDAY, May ... unveils the latest edition of what is considered the ... its many changes continues. "This is unprecedented, the ... Jeffrey Lieberman, president-elect of the American Psychiatric Association (APA). ... what it is. You have to evaluate it and ...
(Date:5/18/2013)... 18 (HealthDay News) -- Children who swallow high-powered magnets ... the objects, according to a new study. The ... New Orleans, found that more than 79 percent of ... surgery or an endoscopic procedure, in which a tube ... Only 21 percent of these cases can be treated ...
Breaking Medicine News(10 mins):Health News:Everything You Need to Know About Lap Band Surgery 2Health News:Everything You Need to Know About Lap Band Surgery 3Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 2Health News:Time and Gems Offers Buyers the Largest Collection of Rolex Watches Yet 3Health News:Illuminations Brings World Renowned Therapist to the Middle East 2Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 2Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 3Health News:Latest Edition of Psychiatry's 'Bible' Launched Amid Controversy 4Health News:Swallowing Magnets Can Be Fatal for Children 2
... WASHINGTON, July 22 The role of personal responsibility in ... Rethinking Responsibility: Reflections on Sex and Accountability. Released ... nonprofit, nonpartisan organization, the volume includes 29 essays written by leaders ... , Leading media voices, ...
... July 22 To help employers face the challenges of ... difficult economy, Sodexo, Inc., now offers a Quality of Life ... today the launch of the program designed to ... , , Sodexo, a ...
... , DALLAS, July 22 Texas ... Heart Association for providing quality, evidence-based care for coronary artery ... "This is another example of the dedication and commitment ... Dallas community by physicians, nursing, allied health professionals and administration," ...
... , WALNUT CREEK, Calif., July 22 ... cure with the recent approval by The National Institutes of Health ... scientists, parents and advocates. , , ... to highlight the work of the NIH,s Research Plan on Fragile ...
... demands of surgical careers, most surgeons would still choose their ... postpone having children or to not have children at all ... national survey conducted by UC Davis researchers has found. The ... Surgery , one of the JAMA/Archives journals. "Surgery is ...
... associated with varied, disproportionate, asymmetric overgrowth of many ... seen in Proteus syndrome is progressive and difficult ... treatment for the progressive overgrowth of tissue over ... functional and cosmetic consequences, so surgical intervention is ...
Cached Medicine News:Health News:National Leaders Examine Sex and Responsibility in New Book 2Health News:National Leaders Examine Sex and Responsibility in New Book 3Health News:Sodexo Offers Landmark Program to Promote Employee Health and Worklife Balance 2Health News:Texas Health Dallas Receives Double Honor From American Heart Association 2Health News:NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X 2Health News:UC Davis study highlights work-life issues of female surgeons 2
(Date:5/18/2013)... -- Although colonoscopy exams prevent many colon cancer deaths ... for detecting colorectal cancers 2 , the procedure is ... EndoChoice ® Inc. today unveiled research that shows ... of this procedure and greatly reduces the number of ... clinical trial results and featuring the Fuse system that ...
(Date:5/18/2013)... , May 18, 2013 The Open ... , Occupy Psychiatry , and leading ... care, announces a social media campaign showcasing video ... psychiatric model, which focuses on pathology and illness ... with the American Psychiatric Association,s (APA) rollout of ...
(Date:5/18/2013)... , May 18, 2013 Faruqi ... firm, is investigating potential securities fraud at AVEO ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... and its executives violated federal securities laws by ... Company,s Phase III drug trials for Tivopath (tivozanib) ...
Breaking Medicine Technology:New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 2New Study Shows Full Spectrum Endoscopy Procedure Reduces The 'Miss Rate' of Adenomas During Colonoscopy 3New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 2New Social Media Campaign Features Stories Of Individuals Who Rejected Psychiatric Diagnoses 3Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2
... The ID-Micro Typing System™ (ID-MTS) ... a broad range of blood ... antibody screening and identification, ABO ... compatibility testing, reverse serum grouping ...
... The Mini-PROTEAN 3 Dodeca cell runs ... conditions in just 35 minutes. Handcast gels ... with the new Model 485 gradient former ... of variation and improving reproducibility. Alternatively, Ready ...
... gels run in the specially designed E-Base™ ... power supply in one device. The daughter ... and to other daughter E-Base™ platforms for ... E-Gel® 96 or E-Gel® 48 gels. Note: ...
... E-Page™ High-Throughput (HTP) Protein ... only integrated pre-cast gel ... high-throughput protein analysis. It ... gels, E-Base™ integrated power ...
Medicine Products: