Navigation Links
Mouse Study May Advance Multiple Sclerosis Research
Date:1/19/2010

Gene mutation in mice causes problems similar to MS in humans, findings show

TUESDAY, Jan. 19 (HealthDay News) -- A mutation in a gene called ZFP191 causes central nervous system myelination problems in mice that are similar to what occurs in humans with multiple sclerosis, new research has found.

In multiple sclerosis, an autoimmune disorder, the body attacks and destroys the myelin sheath that insulates and protects nerve fibers of the central nervous system (brain, spinal cord and optic nerves). Symptoms range from tingling and numbness in limbs to loss of vision and paralysis. The condition affects about 400,000 people in the United States and about 2.5 million people worldwide.

In the new study, Brian Popko of the University of Chicago and colleagues determined that a gene called ZFP191 is necessary for the development of oligodendrocyte cells, which, in their fully mature form, produce myelin. The researchers also found that mice with a single mutation in ZFP191 have a severe deficiency in central nervous system myelination and suffer tremors and seizures.

According to the study, published in the Feb. 1 issue of the journal Genes & Development, the findings may help in efforts to develop ways to promote re-myelination, reduce the accumulation of multiple sclerosis lesions and slow disease progression.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about multiple sclerosis.



-- Robert Preidt



SOURCE: Cold Spring Harbor Laboratory, news release, Jan. 14, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Schizophrenia mouse model should improve understanding and treatment of the disorder
2. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
3. How diarrheal bacteria cause some colon cancers revealed in mouse studies
4. Instant Demo Screen Recorder Now With TrakMouse™ Technology
5. Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
6. Stem cell transplant in mouse embryo yields heart protection in adulthood
7. Astrocytes help separate man from mouse
8. Mouse Study Suggests ADHD Drug Might Be Addictive
9. Living with females extends the reproductive life of the male mouse, says Penn veterinary researcher
10. Cosmetic Surgery -Goldilocks Anesthesia Is Not Mickey Mouse
11. Common anesthetic induces Alzheimers-associated changes in mouse brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is actively feeding the Frederick area economy by obtaining investment capital for emerging ... the past 2½ years that have already resulted in more than a million ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
Breaking Medicine Technology: