Navigation Links
Mouse Study Hints at New Path for Diabetes Treatment
Date:4/12/2012

Diabetes Association, explained that "when you eat a meal and your sugar goes up, glucagon and glucose should switch off, but that doesn't happen in type 2 diabetes."

Currently, type 2 diabetes treatments focus on replacing insulin or making insulin work more effectively (known as improving insulin sensitivity). But, finding a way to block some of the action of glucagon might also help control type 2 diabetes.

The problem is that because glucagon serves a vital function in keeping the brain and body nourished with glucose in times of fasting, scientists can't make a drug that completely suppresses the action of glucagon.

In addition to the brain not getting enough sugar, early research that just partially blocked glucagon caused weight gain, fatty liver deposits and increased cholesterol. Tabas said it's still not entirely clear why partially blocking glucagon caused these effects.

Clearly, a different approach was needed. So, rather than trying to block glucagon, Tabas and his colleagues followed glucagon's pathways.

"Imagine if you have five pathways: A, B, C, D and E. Blocking pathways A and B can stop diabetes. But, if you block C, D, and E, you cause bad effects. So, you have to move further downstream to find the molecules that are responsible for pathways A and B so you can block those without blocking C, D, and E," Tabas explained.

"The more specific you can get, the less likely you'll have adverse effects," he added.

The pathway they found is an enzyme called CaMKII, and Tabas said this particular pathway is also being studied in inflammatory diseases, such as arthritis and asthma, because inhibiting this enzyme seems to lower inflammation as well.

When the researchers blocked CaMKII in obese mice bred to have diabetes, their blood sugar went down, insulin sensitivity improved, cholesterol decreased and fatty liver improved. And, there was no evidence of adverse effects from blocking CaMKII.

"Ther
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Rapamycin rescues learning, memory in Alzheimers mouse model
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Dxtra Introduces New Solid Stainless Steel Mouse Pad
4. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
5. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
6. Fat in Males, Females Differs Genetically, Mouse Study Shows
7. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
8. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
9. Treatment for S. aureus skin infection works in mouse model
10. Mouse Study May Help Explain Fish Oils Benefits
11. Mouse Study Reveals a Cancer Cell Escape Route
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Hints at New Path for Diabetes Treatment
(Date:12/20/2014)... 2014 Recently, AngelWeddingDress.com has introduced its ... for the coming Christmas. In the promotion, all buyers ... , “We have something special for the women who ... season. Moreover, our new collections of 2015 dresses have ... now at greatly discounted prices. Visit our website now ...
(Date:12/20/2014)... The Twin Cities DI Day is ... the nation! Over 250 financial professionals come together each ... the industry, get motivated to protect their clients and ... and overcoming the challenges of disability. , On September ... came together to attend The 13th Annual Twin Cities ...
(Date:12/19/2014)... Today, Balfleet.com , a leading dress company ... dress promotion. All the old and new customers can ... Balfleet.com is well-known for its high quality trendy women’s ... dresses and more. Its formal dresses are quality made ... can create an elegant look when paired with any ...
(Date:12/19/2014)... 19, 2014 Sub Zero Ice Cream is ... blood drive Sunday the 28th from 2pm-6pm at the Expo ... Road in Sarasota, FL. , Inquiries regarding time slots and ... participating in the donating process, Sub Zero Ice Cream & ... custom ice cream. , About Sub Zero Ice Cream & ...
(Date:12/19/2014)... December 19, 2014 Silver Dollar City ... world record -- for the first time ever, Silver Dollar ... book, Guinness World Records 2015, listing the park’s wood coaster ... Coaster. In additional awards announced this week, Silver Dollar City ... Lights in the US,” USA Today’s 10Best awards for “Best ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2
... Lazard CEO Bruce Wasserstein comes under fire as ... care facilities value,private equity gain over safety measures; ... and Wasserstein greed, NEW YORK, July 7 ... launched an online campaign today to,bring attention to ...
... Scientists have identified a new antitumor drug that might ... cancers. The research, published by Cell Press in the ... , advances the understanding of one of the most ... provides new insight into the regulation of the complex ...
... staffing issues and geographic boundaries are some of the ... they plan for a possible influenza pandemic, according to ... health experts who are leading planning efforts for an ... counties, as defined by political lines," said George Avery, ...
... VirtualHealth,Technologies, Inc. (OTC Bulletin Board: VHGI) the ... Prescription Monitoring System announced,it,s support today of ... the electronic,prescribing of controlled substances., June ... would allow physicians to electronically prescribe controlled,substances. ...
... has been found to play a major role in,keeping ... hematopoietic,stem cells, MEMPHIS, Tenn., July 7 The ... run-of-the-mill enzyme that helps to,recycle molecules in cells causes ... St. Jude Children,s Research Hospital investigators., Children with ...
... wine, grape skins, inhibits abnormal cells, study finds , , ... in red grapes and red wine suppresses abnormal cell ... according to U.S. researchers. , The compound, resveratrol, is ... Breast cancer forms through a multi-stage process that differs ...
Cached Medicine News:Health News:Exploitation of Residents at Wasserstein and Lazard-linked Senior Care Facilities Exposed 2Health News:Bacterial peptide provides new insight into common tumor suppressor 2Health News:Political borders, health-care issues complicate pandemic planning 2Health News:Political borders, health-care issues complicate pandemic planning 3Health News:E-prescribing of Controlled Substances Moves Real-Time Prescription Drug Monitoring Toward Reality 2Health News:St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease 2Health News:St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease 3Health News:St. Jude Study Reveals a New Function for an Old Enzyme in Fatal Childhood Disease 4Health News:Dietary Supplement May Prevent Breast Cancer 2
(Date:12/17/2014)... , Dec. 17, 2014  Northstar Global Business ... Trust Company (DTC) has made their final decision ... on the Company,s stock effective December 15, 2014, ... stock for depository and book entry transfer services. All ... is now once again fully "DTC Eligible", and ...
(Date:12/17/2014)... Dec. 17, 2014  Beamz Interactive, Inc. (OTCQB: ... products, today announced that it has signed an ... and supplier of innovative prosthetic, orthotic and assistive ... of the agreement, RSL Steeper will promote and ... configured for use within UK residential care facilities ...
(Date:12/17/2014)... LOS ANGELES , Dec. 17, 2014 /PRNewswire/ ... that the US Patent and Trademark Office (USPTO) ... candidate ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting ... glioblastoma. The claims of US Patent No. 8,871,211, ... treating neural cancer by administering a dendritic cell ...
Breaking Medicine Technology:Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... SAN DIEGO, June 16, 2011 Neurocrine Biosciences, Inc. ... elagolix presentations have been accepted for the scientific program ... September 4-7, 2011 in Montpellier, France. This important meeting ... every three years, bringing together clinicians and basic scientists ...
... 2011 Cebix Incorporated announced today it ... for the treatment of complications of diabetes. The biopharmaceutical ... evaluate Ersatta™, its proprietary long-acting form of C-peptide, in ... disease, lack this endogenous peptide.  Following the successful completion ...
Cached Medicine Technology:Neurocrine Biosciences Announces elagolix Scientific Presentations at the 11th World Congress on Endometriosis 2Neurocrine Biosciences Announces elagolix Scientific Presentations at the 11th World Congress on Endometriosis 3Cebix Initiates Phase 1b Clinical Trial with Drug Candidate Ersatta™ 2Cebix Initiates Phase 1b Clinical Trial with Drug Candidate Ersatta™ 3Cebix Initiates Phase 1b Clinical Trial with Drug Candidate Ersatta™ 4
Karlin Lumbar Microdiscectomy Curette, length 9 1/2" (24.13 cm)....
PG Magnum Cup Curettes with large capacity cup sizes, total length 12.6" (32 cm) handle length 7.8" (20 cm), handle diameter 1.12" (3 cm), working distance 4.7" (12 cm)....
Karlin Cervical Microdiscectomy Curette, length 8 1/2" (21 cm)....
Microsect Curette with increased cutting edge and modified shaft, 10"....
Medicine Products: