Navigation Links
Mouse Study Gives Clues to Colitis
Date:10/5/2007

A key immune deficiency can spur the disease, researchers say

FRIDAY, Oct. 5 (HealthDay News) -- U.S. researchers say they've identified a specific immune deficiency that's the likely cause of ulcerative colitis -- at least in mice.

A team at the Harvard School of Public Health (HSPH) said the problem may lie in a deficiency of the T-bet protein in dendritic cells -- white blood cells that detect foreign microbes and activate the immune system.

The lack of T-bet allows harmful bacteria in the large intestine to breach the bowel's protective lining and trigger damaging inflammation, the researchers said. They also found that once the disease was established in mice, it could be passed from mothers to offspring and even between adults, a discovery that has potential implications for public health and prevention.

The study was published online Thursday in the journal Cell.

"We have identified a new molecular player, T-bet, and when it's missing, there is spontaneous onset of the disease in mice. The importance of this study is that we now have a novel model for ulcerative colitis; the disease appears in 100 percent of the animals (that lack T-bet) and looks just like the human disease," team leader Laurie Glimcher, a professor of immunology at HSPH and a professor of medicine at Harvard Medical School, said in a prepared statement.

About half a million Americans have ulcerative colitis, a chronic and sometimes severe inflammatory disease of the colon or large intestine.

Because this mouse model closely resembles human ulcerative colitis, it may prove important for testing new therapies and preventive measures, Glimcher said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about ulcerative colitis.



-- Robert Preidt



SOURCE: Harvard School of Public Health, news release, Oct. 4, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... 2017 , ... Accreditation Commission for Health Care (ACHC) is ... (HCAOA). This agreement allows HCAOA members to receive special pricing on ACHC’s Home ... University (AU) educational resources that help prepare HCAOA members for ACHC Accreditation. , ...
(Date:4/28/2017)... ... ... Horizon Blue Cross Blue Shield of New Jersey (BCBSNJ) announced today that ... as “stable.” At the same time, the ratings agency cautioned that the company’s rating ... “capital adequacy” thresholds required for its strong rating. , “Horizon is committed to being ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... tubes . These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps ... fixtures or disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ...
(Date:4/28/2017)... ... ... The Texas Cord Blood Bank (TCBB), a program of nonprofit biomedical organization GenCure, ... at Renaissance in Edinburg for their outstanding efforts in collecting umbilical cord blood donations ... , “Women’s Hospital at Renaissance has been a collection partner for the TCBB since ...
(Date:4/28/2017)... Ca (PRWEB) , ... April 28, 2017 , ... Bill ... management industry in the coastal communities. After Tina Howe joined the team, the Bill ... happy employees, honest services at affordable rates, and giving back to the San Diego ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  IRIDEX Corporation (Nasdaq: ... financial results for the first quarter 2017 after the ... Company,s management team will host a corresponding conference call ... Investors interested in listening to the conference ... domestic callers or (703) 326-3030 for international callers, using ...
(Date:4/19/2017)... April 19, 2017 Global Prostate Cancer ... on the prostate cancer therapeutics market analyzes the ... Increasing prevalence of prostate cancer, launch of promising ... development of new drugs & therapeutic biological products, ... due to lesser side effects are some of ...
(Date:4/19/2017)... -- The Global Effective Microorganisms (EM) Market by ... covered and analysed the potential of Global Effective Microorganisms (EM) ... and growth factors. The report identifies and analyses the emerging ... global market. ... Tables and Figures, 6 Major Company Profiles, spread across 124 ...
Breaking Medicine Technology: