Navigation Links
Mouse Study Gives Clues to Colitis

A key immune deficiency can spur the disease, researchers say

FRIDAY, Oct. 5 (HealthDay News) -- U.S. researchers say they've identified a specific immune deficiency that's the likely cause of ulcerative colitis -- at least in mice.

A team at the Harvard School of Public Health (HSPH) said the problem may lie in a deficiency of the T-bet protein in dendritic cells -- white blood cells that detect foreign microbes and activate the immune system.

The lack of T-bet allows harmful bacteria in the large intestine to breach the bowel's protective lining and trigger damaging inflammation, the researchers said. They also found that once the disease was established in mice, it could be passed from mothers to offspring and even between adults, a discovery that has potential implications for public health and prevention.

The study was published online Thursday in the journal Cell.

"We have identified a new molecular player, T-bet, and when it's missing, there is spontaneous onset of the disease in mice. The importance of this study is that we now have a novel model for ulcerative colitis; the disease appears in 100 percent of the animals (that lack T-bet) and looks just like the human disease," team leader Laurie Glimcher, a professor of immunology at HSPH and a professor of medicine at Harvard Medical School, said in a prepared statement.

About half a million Americans have ulcerative colitis, a chronic and sometimes severe inflammatory disease of the colon or large intestine.

Because this mouse model closely resembles human ulcerative colitis, it may prove important for testing new therapies and preventive measures, Glimcher said.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about ulcerative colitis.

-- Robert Preidt

SOURCE: Harvard School of Public Health, news release, Oct. 4, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Mouse Allergen Found In Homes Could Trigger Asthma In Kids
2. Researchers Develop Mouse Model Of Brain Tumor
3. German Scientists Create Stem Cells From Mouse Testes
4. Mouse Models To Determine The Cause Of Aggressive Leukemia
5. Mouse Model Beneficial to Study of Head and Neck Cancer
6. Scientists Discover New RNAs in Mouse Testicles
7. Scientists Isolate Leukemia Stem Cells in Mouse Model
8. Mouse Model Demonstrates Immune System Reaction In Chlamydia Infection
9. Mouse Gene With Gene Stutter Will Help Leukemia Research
10. Rett Syndrome Reversed in Genetic Mouse Model
11. Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Post Your Comments:
(Date:12/1/2015)... ... 2015 , ... Speech and physical therapies are traditionally conducted ... and under the right circumstances, these practices can be merged. This combination ... his or her therapeutic sessions, as well as gives the physical and speech ...
(Date:12/1/2015)... ... December 01, 2015 , ... It’s official: Tattoo taboo is a ... number even greater among Millennials (a whopping one in three aged 18 to 25 ... who are dissatisfied with their ink. In fact, RealSelf , the world’s largest ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... everything. That is why Hollister Incorporated has launched the VaPro Plus Pocket™ touch ... product in the VaPro touch free catheter portfolio,” said Michael Gresavage, Vice President ...
(Date:12/1/2015)... Burlington, MA (PRWEB) , ... December 01, 2015 , ... ... the release of Clarity, the latest addition to the devices for sale in the ... technologies, 755 nm Alexandrite and long-pulsed 1064 nm Nd:YAG lasers, into a single platform ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , ... control over customization, the possibilities are truly endless, all with a click of a ... position, vertical flip, horizontal flip, depth of field and more, all within Final Cut ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015   Craneware, Inc ... cycle solutions, today announced the company will showcase ... ChargeLink ® solution at the American ... Clinical Meeting . The new features are focused ... of monitoring and managing enterprise-wide pharmacy charges to ...
(Date:12/1/2015)... -- Booth #3506 – Claymount is featuring its full line of ... Radiological Society of North America (RSNA) ... the Netherlands , Claymount is part of ... VAR ) and is one of the world,s leading suppliers ... exposure control systems for controlling dose during medical X-ray imaging. ...
(Date:12/1/2015)... WASHINGTON and TELTOW, Germany ... SensoMotoric Instruments (SMI) , a leading global manufacturer of ... RightEye LLC has included SMI remote eye trackers ... that help healthcare providers assess concussions, eye sight, and ... SMI RED -oem technology is part of SMI,s mass-market-ready ...
Breaking Medicine Technology: