Navigation Links
Mouse Study Give Clues to Why Exercise Is Healthy
Date:1/11/2012

WEDNESDAY, Jan. 11 (HealthDay News) -- Researchers have identified a protein in muscle cells that triggers some of the health benefits of exercise in mice.

"There has been a feeling in the field that exercise 'talks to' various tissues in the body," said the study's senior author, Bruce Spiegelman, a cell biologist at Dana-Farber Cancer Institute in Boston and a professor of cell biology at Harvard Medical School, in a news release from the centers. "But the question has been, how?"

Known as "irisin" (after the Greek messenger goddess, Iris), the protein acts as a chemical messenger and may eventually be used to develop new treatments for diabetes, obesity and possibly cancer, Spiegelman and colleagues said. Their report is published online Jan. 11 in the journal Nature.

Exercise causes irisin levels to rise, the researchers explained. They found the protein has "powerful effects" on adipose, or deposits of white fat under the skin that store extra calories and contribute to obesity.

After injecting the protein into sedentary mice that were obese and prediabetic, the protein activated genes that convert white fat into "good" brown fat, which burns more calories than exercise alone.

However, they noted that irisin does not build muscle so it can never replace exercise.

The report also revealed that irisin improved glucose tolerance in mice that received a high-fat diet. After 10 days of treatment with irisin, the mice had better-controlled blood sugar and insulin levels, preventing the onset of diabetes and helping them to lose excess weight.

"It's exciting to find a natural substance connected to exercise that has such clear therapeutic potential," said study first author Dr. Pontus Bostrom, a postdoctoral fellow in the Spiegelman lab, in the news release.

The researchers said it's possible that an irisin-based drug could be ready for clinical trial in humans within two years.

Ember Therapeutics, a Boston startup company co-founded by Spiegelman, has rights to the drug's development.

While the findings of the new study might be promising, scientists note that research involving animals often fails to produce similar results in humans.

The U.S. National Institutes of Health sponsored the research.

More information

The U.S. National Institutes of Health provides more information on the health benefits of exercise.

-- Mary Elizabeth Dallas

SOURCE: Dana-Farber Cancer Institute, news release, Jan. 9, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene expression in mouse neural retina sequenced
2. UGA researchers develop first mouse model to study important aspect of Alzheimer’s
3. Drinking Patterns Affect Heart Health, Mouse Study Finds
4. Mouse Study Could Give New Clues to Fighting Baldness
5. New mouse model for testing cancer drugs
6. Human Stem Cells Used to Fix Damaged Mouse Heart
7. Mouse Study Uncovers the Roots of Gray Hair
8. Mouse Study Reveals How Smoking Helps Keep People Thin
9. Apples Help Keep Muscles Strong, Mouse Study Finds
10. Scientists create humanized mouse model for hepatitis C
11. Pitt researchers build a better mouse model to study depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Give Clues to Why Exercise Is Healthy
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: