Navigation Links
Mouse Study Finds Molecule That Tells Hair to Grow
Date:7/31/2008

Could one day lead to treatments for baldness, researchers say

THURSDAY, July 31 (HealthDay News) -- Scientists have taken a step forward in understanding the mechanisms behind a problem that has bedeviled many men, and some women, for all of history: hair loss.

The study identifies a key signaling molecule that tells hair follicles to start the hair-growing cycle.

"These are very complex molecular signals, and the authors have very nicely shown that there is one molecule, laminins 511, that is a very important signal to tell the hair molecule to move through the process. It's part of a basic biological understanding," said Dr. Ronald Crystal, chairman of genetic medicine at New York Presbyterian Weill Cornell Medical Center in New York City.

The researchers, reporting in the Aug. 1 issue of Genes & Development, feel the findings may one day hold the key to treating male-pattern baldness, as well as hair loss from chemotherapy or even to restore hair on burn victims.

But, as so often happens, the study was conducted in mice and, as Crystal pointed out, "Mice are not just little men and women. They are different than us and also different in their hair."

A series of complex molecular signals tell hair follicles to go through a cycle of follicle growing, hair growing, follicle receding and hair receding, Crystal explained.

The same group of researchers had previously found that the protein laminin-511 was important to hair development.

In this study, the authors found out why. It was originally thought that laminin-511 was made from the cells of the outer layer of the skin (epithelium) and acted on the epithelium.

It now turns out, however, that the protein, although produced by the epithelium, actually penetrates into the inner layer of the skin (dermis) to kick start the hair-growing process.

"So laminin-511 is an early epithelial message to the dermis to say let's start producing hair," said study senior author Dr. Peter Marinkovich, an associate professor of dermatology at Stanford University School of Medicine and member of the Stanford Cancer Center. "Hair is formed as a result of cooperation and communication between the two layers."

"We knew that the two layers of the skin are important in hair formation, and we knew that there was some early epithelial signal hypothesized a long time ago, but no one knew what it was until now," he added.

In mice, laminin-511 convinced hair to grow at the equivalent of about the eighth month of pregnancy, but Marinkovich and his colleagues are hoping it might also work later in the life cycle.

Male baldness associated with aging would be an obvious target. "The hair follicles are still there, but they get stuck in the cycle, so it's not well understood why they're stuck and . . . how do you get them unstuck," Crystal said. "The hope, of course, is that you can apply this to humans, but there are some cautions in all that. Biology is very complex. There are a lot of checks and balances. You don't want hair follicles and cells in hair follicles to be growing too much or not enough. The on-and-off signals that are dampening that and controlling that are very, very complex and not well understood. This is far, far from humans."

More information

For more on male-pattern baldness, visit the U.S. National Library of Medicine.



SOURCES: Ronald Crystal, M.D., chairman, genetic medicine, New York Presbyterian Weill Cornell Medical Center, New York City; Peter Marinkovich, M.D., associate professor, dermatology, Stanford University School of Medicine, and member, Stanford Cancer Center; Aug. 1, 2008, Genes & Development


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumor suppressor genes speed up and slow down aging in engineered mouse
2. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
3. Mouse Adult Stem Cells Developed into Heart and Blood Cells
4. Mature Mouse Cells Reprogrammed to Stem Cell-Like State
5. Boston College biologists build a better mouse model for cancer research
6. Mouse model for mesothelioma reproduces human disease
7. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
8. Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
9. Mouse Model of Age-Related Macular Degeneration Developed
10. Gene Tweak Reverses Aging in Mouse Skin Cells
11. A longer-living, healthier mouse that could hold clues to human aging
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mouse Study Finds Molecule That Tells Hair to Grow
(Date:1/23/2017)... ... January 23, 2017 , ... DMG Productions is proud to ... Jr., scheduled to broadcast Saturday, January 28, 2017 at 5:00pmEST. , This segment ... to address the limitations of fatigue monitoring technologies within the mining industry. Today ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... taught by healthcare management and evaluation leaders with decades of experience who remain ... in the United States healthcare system, there is a renewed demand for versatile, ...
(Date:1/23/2017)... Indiana (PRWEB) , ... January 23, 2017 , ... ... Center for Assisted Living (IHCA/INCAL), will serve as a healthcare industry expert at ... 23. The panel discussion, moderated by Inside Indiana Business host Gerry Dick, will ...
(Date:1/23/2017)... ... 23, 2017 , ... Steviva Ingredients, makers of all-natural sweeteners ... National Organic Program (NOP) for its Portland SQF Level 2 manufacturing facility. ... handling systems to complement our current rigorous food-safety management systems,” said Yishu Hou, ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... partnership with the American Society of Anesthesiologists® (ASA®), the Foundation for Anesthesia ... Academy of Orthopaedic Surgeons (AAOS) and the Cigna Foundation, encourages proposals supporting ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... Jan. 20, 2017 ResMed (NYSE: RMD ), ... Winter Haven, Florida ) today announced they have agreed ... and 3B will be permitted to sell their existing products in ... one-time settlement payment to 3B to close the Florida ... include an admission of liability or wrongdoing by any party. ...
(Date:1/21/2017)... Jan. 20, 2017  Faruqi & Faruqi, LLP, a leading ... or the "Company") (NASDAQ: KMPH ) of the ... certain officers and directors and underwriters of the Company,s April ... role of lead plaintiff. The lawsuit has been ... for Johnson County on behalf of ...
(Date:1/20/2017)... Research and Markets has announced the addition of the ... to their offering. ... This research service on the global pharmaceutical stability testing market ... of the key participants in the market. The ... 2020. The market is expected to grow at a CAGR of ...
Breaking Medicine Technology: