Navigation Links
Mouse Sperm Successfully Grown in Lab, Researchers Say

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, March 23 (HealthDay News) -- Researchers report that they've grown mouse sperm from testicular tissue in the laboratory, a development that could advance the field of infertility in human males.

Although the findings only apply to mice, "this is a small but important step in understanding how sperm are formed, which may, in time, lead to us being able to grow human sperm in the laboratory," said Dr. Allan Pacey, senior lecturer in andrology at the University of Sheffield in England, who is familiar with the study results.

Sperm production is highly complex, the authors explained in background information in the study. Sperm previously created in a laboratory from mammal tissue didn't fulfill its purpose, Pacey said, noting offspring produced from it soon died.

For this study, published in the March 24 issue of the journal Nature, researchers took tissue from the testes of baby mice and coaxed it into producing sperm cells. They then inseminated female mice, which had healthy babies.

Moreover, the frozen sperm remained viable for months, the authors said.

Physicians caution that the research would need confirmation by other studies in animals and humans before it could become feasible to grow human sperm in a laboratory. But the potential exists for the procedure to help some cases of male infertility.

"It will be useful for diagnosis and treatment of infertility in future, for sure," said study co-author Dr. Takehiko Ogawa, a urologist at Yokohama City University Graduate School of Medicine in Japan.

And the sperm-growing procedure shouldn't be expensive, Ogawa added.

Boys with childhood cancer are one potential treatment group because chemotherapy treatments can cause infertility. Before undergoing chemo, it's conceivable that young men can have their sperm stored for later use. But if the boys are too young to produce sperm, the laboratory technique may hold some promise.

"Years later, grown sperm in the laboratory could allow them to have children that were genetically theirs," Pacey said. However, legal issues may arise regarding obtaining testicular tissue from kids who aren't old enough to give consent, he added.

Dr. Robert D. Oates, professor of urology at Boston University School of Medicine, said: "We're doing such a great job of curing people that we need to think about the other long-term issues, of which fertility is one. It's nice that they can have a full adulthood like the rest of us do and are able to have kids."

As for infertile men, eventually it may be possible to take their tissue and grow sperm outside their bodies instead of searching for rare working sperm through biopsies of their testicles, said Dr. Ian Cooke, emeritus professor of obstetrics and gynecology at the University of Sheffield.

But if genetic problems caused their infertility in the first place, growing sperm outside the body wouldn't make any difference, Cooke said.

More information

For more about infertility, visit the U.S. National Library of Medicine.

SOURCES: Allan Pacey, B.Sc., Ph.D., senior lecturer in andrology, and Ian Cooke, M.D., emeritus professor of obstetrics and gynecology, University of Sheffield, England; Robert D. Oates, M.D., professor of urology, Boston University School of Medicine; Takehiko Ogawa, M.D., Ph.D., urologist, Yokohama City University Graduate School of Medicine, Japan; March 24, 2011, Nature

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Rapamycin rescues learning, memory in Alzheimers mouse model
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Dxtra Introduces New Solid Stainless Steel Mouse Pad
4. UCSF Transgenic Mouse Mimics Parkinson's Earliest Symptoms
5. McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
6. Fat in Males, Females Differs Genetically, Mouse Study Shows
7. Ergonomic HandShoe Mouse Publish Proof of Unique Difference with Competition
8. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
9. Treatment for S. aureus skin infection works in mouse model
10. Mouse Study May Help Explain Fish Oils Benefits
11. Mouse Study Reveals a Cancer Cell Escape Route
Post Your Comments:
Related Image:
Mouse Sperm Successfully Grown in Lab, Researchers Say
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in ... ways they remain in the eye of the beholder, according to experts who offered ... The American Journal of Managed Care. For the full issue, click here . ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology: