Navigation Links
Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
Date:4/30/2008

New cells were coaxed into becoming three kinds of cardiac cells

WEDNESDAY, April 30 (HealthDay News) -- Functioning cardiac cells have been created from mouse skin cells reprogrammed to have the same unlimited differentiation characteristics of embryonic stem cells, say researchers at the University of California, Los Angeles.

This is the first study to show that induced pluripotent stem (iPS) cells, which don't involve the use of embryos or eggs, can be directed to develop into the three types of cardiovascular cells needed to repair the heart and blood vessels, the researchers said.

The finding could help lead to new treatments for heart attack, heart failure and atherosclerosis.

The UCLA team also differentiated the iPS cells into several types of blood cells, something that may one day help in treating blood diseases and in bone marrow transplantation.

The study was published online in the May 1 issue of Stem Cells.

"I believe iPS cells address many of the shortcomings of human embryonic stem cells and are the future of regenerative medicine," senior author Dr. Robb MacLellan, a researcher at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, said in a prepared statement.

"I'm hoping that these scientific findings are the first step towards one day developing new therapies that I can offer my patients. There are still many limitations with using iPS cells in clinical studies that we must overcome, but there are scientists in labs across the country working to address these issues right now," said MacLellan, an associate professor of cardiology and physiology.

While it's believed that iPS cells are very similar to embryonic stem cells, further research must be done to confirm the differentiation potential of iPS cells. This finding that iPS cells can become cardiovascular cells is an important step in that confirmation process.

"Theoretically, iPS cells are able to differentiate into 220 different cell types. For the first time, scientists from UCLA were able to induce the differentiation of mouse iPS cells into functional heart cells," Dr. Miodrag Stojkovic, co-editor of Stem Cells, said in a prepared statement.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, April 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Mouse Adult Stem Cells Developed into Heart and Blood Cells
2. Mature Mouse Cells Reprogrammed to Stem Cell-Like State
3. Boston College biologists build a better mouse model for cancer research
4. Mouse model for mesothelioma reproduces human disease
5. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
6. Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
7. Mouse Model of Age-Related Macular Degeneration Developed
8. Gene Tweak Reverses Aging in Mouse Skin Cells
9. A longer-living, healthier mouse that could hold clues to human aging
10. Mouse mammary tumor virus can replicate in human cells
11. Mouse Study Gives Clues to Colitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, the worldwide ... (ABT), an innovative braking system that allows skaters of all levels to stop ... the biggest concerns of beginner and intermediate skaters – learning how to brake ...
(Date:1/18/2017)... ... 18, 2017 , ... Floundering on New Year’s resolutions? Need an excuse to ... a reset. The U.S. Apple Association agrees and recommends starting each day with ... contribute to heart disease. , The U.S. Apple Association – which represents apple growers ...
(Date:1/17/2017)... ... ... Anesthesia Progress – Everyone wants less pain during dental surgery, but ... patient. Dentists have several general anesthesia alternatives and finding the right option can result ... College in Tokyo, Japan wanted to find out which anesthetic was the better choice ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... of difference. Eden Activewear is a stand-out company for several differences from other ... and only manufacture on demand, this is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, to help those who ... powerfully uplifting interview with medical expert and prolific author, Dr. Bernie Siegel. ... tough times, Dr. Bernie Siegel energizes listeners to live life with intrigue, magic ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Israel , January 17, 2017 Management ... TyrNovo, Ltd.   KIT-302 Development On Track For ... FDA in Q1 2017   ... Kitov Pharmaceuticals Holdings Ltd. (NASDAQ: KTOV ; ... update call on Monday, January 23 rd at 8:30am Eastern Time to ...
(Date:1/17/2017)... 17, 2017  Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... enrolled in a Phase 3 clinical trial comparing the ... (BSC) in the prevention of hepatic veno-occlusive disease (VOD) ... transplant (HSCT) who are at high risk or at ... trial will be conducted across approximately 100 medical centers ...
(Date:1/17/2017)... Calif. , Jan. 17, 2017  Edwards Lifesciences ... in patient-focused innovations for structural heart disease and critical ... the quarter ended December 31, 2016 after the market ... a conference call at 5:00 p.m. ET that day ... the conference call, dial (877) 407-8037 or (201) 689-8037.  ...
Breaking Medicine Technology: