Navigation Links
Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
Date:4/30/2008

New cells were coaxed into becoming three kinds of cardiac cells

WEDNESDAY, April 30 (HealthDay News) -- Functioning cardiac cells have been created from mouse skin cells reprogrammed to have the same unlimited differentiation characteristics of embryonic stem cells, say researchers at the University of California, Los Angeles.

This is the first study to show that induced pluripotent stem (iPS) cells, which don't involve the use of embryos or eggs, can be directed to develop into the three types of cardiovascular cells needed to repair the heart and blood vessels, the researchers said.

The finding could help lead to new treatments for heart attack, heart failure and atherosclerosis.

The UCLA team also differentiated the iPS cells into several types of blood cells, something that may one day help in treating blood diseases and in bone marrow transplantation.

The study was published online in the May 1 issue of Stem Cells.

"I believe iPS cells address many of the shortcomings of human embryonic stem cells and are the future of regenerative medicine," senior author Dr. Robb MacLellan, a researcher at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, said in a prepared statement.

"I'm hoping that these scientific findings are the first step towards one day developing new therapies that I can offer my patients. There are still many limitations with using iPS cells in clinical studies that we must overcome, but there are scientists in labs across the country working to address these issues right now," said MacLellan, an associate professor of cardiology and physiology.

While it's believed that iPS cells are very similar to embryonic stem cells, further research must be done to confirm the differentiation potential of iPS cells. This finding that iPS cells can become cardiovascular cells is an important step in that confirmation process.

"Theoretically, iPS cells are able to differentiate into 220 different cell types. For the first time, scientists from UCLA were able to induce the differentiation of mouse iPS cells into functional heart cells," Dr. Miodrag Stojkovic, co-editor of Stem Cells, said in a prepared statement.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, April 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Mouse Adult Stem Cells Developed into Heart and Blood Cells
2. Mature Mouse Cells Reprogrammed to Stem Cell-Like State
3. Boston College biologists build a better mouse model for cancer research
4. Mouse model for mesothelioma reproduces human disease
5. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
6. Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
7. Mouse Model of Age-Related Macular Degeneration Developed
8. Gene Tweak Reverses Aging in Mouse Skin Cells
9. A longer-living, healthier mouse that could hold clues to human aging
10. Mouse mammary tumor virus can replicate in human cells
11. Mouse Study Gives Clues to Colitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... ... production of its newest mobility device, the StandUp Walker. Made entirely in the ... in the last 50 years. , StandUp Walker’s novel patent-pending design offers 2-in-1 ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... LLC to help enterprises move workloads to the cloud. Cirracore provides a ... their cloud without traversing the Internet. Transformation Solutions (TSL Partners) provides a ...
(Date:2/9/2016)... ... February 09, 2016 , ... BioPlus Specialty Pharmacy (BioPlus), one ... ‘Pay It Forward’ program into 2016. BioPlus partners with several non-profit patient foundations ... , “Since our Pay It Forward program began, we are proud to have ...
(Date:2/9/2016)... ... ... On January 12, 2016 Paul McElwee, a CroppMetcalfe HVAC technician, visited a home ... any heat. Shortly after entering the home, Paul was able to identify the problem ... carbon monoxide into the home, at 2,000 parts per million in the flue. Anything ...
(Date:2/9/2016)... ... February 09, 2016 , ... The Bon-Ton Stores, Inc. ... department stores, announced it has raised $176,000 to benefit the Breast Cancer Research ... Center at the University of Iowa, The Lynn Sage Cancer Research Foundation, and ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... "Company") (NASDAQ: UNIS ; ASX: UNS), a developer and ... for the second quarter of fiscal 2016 (three months ended December ... Financial Results for the Second Quarter of Fiscal 2016 ... the second quarter of fiscal 2016 was $4.5 million, compared to ... customers for the second quarter of fiscal 2016 were $17.8 million, ...
(Date:2/9/2016)... 2016  Axovant Sciences Ltd. (NYSE:  AXON), a ... of dementia, today announced further details of three ... functional aspects of Lewy body dementia, a disease ... Two out of the three studies were recently ... later this quarter. In addition, the Company reported ...
(Date:2/9/2016)... Hearing protection devices refer to the barriers that reduce ... ear. Hearing protection devices include earplugs, uniform attenuation earplug, ... users exposed to noise levels of over 80 dB ... inserted in the ear canal to protect the ear. ... sound perception with the help of acoustic filters. Earmuffs ...
Breaking Medicine Technology: