Navigation Links
Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
Date:4/30/2008

New cells were coaxed into becoming three kinds of cardiac cells

WEDNESDAY, April 30 (HealthDay News) -- Functioning cardiac cells have been created from mouse skin cells reprogrammed to have the same unlimited differentiation characteristics of embryonic stem cells, say researchers at the University of California, Los Angeles.

This is the first study to show that induced pluripotent stem (iPS) cells, which don't involve the use of embryos or eggs, can be directed to develop into the three types of cardiovascular cells needed to repair the heart and blood vessels, the researchers said.

The finding could help lead to new treatments for heart attack, heart failure and atherosclerosis.

The UCLA team also differentiated the iPS cells into several types of blood cells, something that may one day help in treating blood diseases and in bone marrow transplantation.

The study was published online in the May 1 issue of Stem Cells.

"I believe iPS cells address many of the shortcomings of human embryonic stem cells and are the future of regenerative medicine," senior author Dr. Robb MacLellan, a researcher at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, said in a prepared statement.

"I'm hoping that these scientific findings are the first step towards one day developing new therapies that I can offer my patients. There are still many limitations with using iPS cells in clinical studies that we must overcome, but there are scientists in labs across the country working to address these issues right now," said MacLellan, an associate professor of cardiology and physiology.

While it's believed that iPS cells are very similar to embryonic stem cells, further research must be done to confirm the differentiation potential of iPS cells. This finding that iPS cells can become cardiovascular cells is an important step in that confirmation process.

"Theoretically, iPS cells are able to differentiate into 220 different cell types. For the first time, scientists from UCLA were able to induce the differentiation of mouse iPS cells into functional heart cells," Dr. Miodrag Stojkovic, co-editor of Stem Cells, said in a prepared statement.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, April 30, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Mouse Adult Stem Cells Developed into Heart and Blood Cells
2. Mature Mouse Cells Reprogrammed to Stem Cell-Like State
3. Boston College biologists build a better mouse model for cancer research
4. Mouse model for mesothelioma reproduces human disease
5. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
6. Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
7. Mouse Model of Age-Related Macular Degeneration Developed
8. Gene Tweak Reverses Aging in Mouse Skin Cells
9. A longer-living, healthier mouse that could hold clues to human aging
10. Mouse mammary tumor virus can replicate in human cells
11. Mouse Study Gives Clues to Colitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... ... reminds us that May is National Stroke Awareness Month. According to the Centers for ... the United States; someone has one every 40 seconds. Annually, almost 800,000 strokes occur ... A stroke is when blood flow to the brain is blocked or when a ...
(Date:4/28/2016)... MA (PRWEB) , ... April 28, 2016 , ... A ... were typical among 18 states studied, the Workers Compensation Research Institute (WCRI) ... The WCRI study, CompScope™ Benchmarks for Kentucky, 16th Edition , found that indemnity ...
(Date:4/28/2016)... ... April 28, 2016 , ... SyncDog, Inc. ... its leading secure mobility workstation suite, SentinelSecure™, at MobileIron’s 6th annual Mobile First ... this will be MobileIron’s 6th Mobile First Conference and will feature immersive training, ...
(Date:4/28/2016)... ... 2016 , ... For the 10,000 Americans who turn 65 on any given ... overall well-being: mental health. Now, a new book—Staying Sharp For Dummies (Paper; ISBN: 978-1-119-18779-0; ... which can include everything from honing your memory and managing stress to eating healthy ...
(Date:4/28/2016)... , ... April 28, 2016 , ... The USDA recently ... based on the latest nutritional science. While there is a lot of information available ... health, according to the April 2016 issue of Harvard Men's Health Watch . ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... consumer insights on healthcare, announced today that it has ... report Cool Vendor in Life Sciences, 2016, ... 15, 2016.  The report focuses on life-science- oriented analytics, ... insight from patients and doctors, confirm medication ingestion, and ...
(Date:4/28/2016)... MARLTON, N.J. , April 28, 2016   ... solutions, today announced that leading IT market research and ... Player " in the IDC MarketScape: Worldwide Pharmaceutical Track ... March 2016).  The report provides an assessment of the ... pharmaceutical track and trace software market. Logo ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
Breaking Medicine Technology: