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Mouse Adult Stem Cells Developed into Heart and Blood Cells
Date:4/30/2008

S cells to develop into functional cardiomyocytes, smooth muscle cells, and hematopoietic cells. The functional cells showed only minor differences from cells developed from embryonic stem cells.

The ability to generate stem cells using the patient's own cells holds great promise for the treatment of currently incurable degenerative diseases, as well as for cell-based drug discovery. In recent months, reports from UCLA and other research groups have shown that human skin cells can be reprogrammed into cells that are nearly identical to human embryonic stem cells, without the need to use human embryos or eggs.

The new results are an important milestone, extensively documenting the capability of inducing mouse iPS cells to develop into different types of functional cells. The next step will be to develop efficient, reliable, and safe techniques of generating human cardiovascular and hematopoietic cells for use in testing new "patient-tailored regenerative therapies," the researchers write.

Dr. Stojkovic adds, "The development of functional cells from iPS is a key step forward in the development of patient-specific embryonic stem cells for use in developing new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and spinal cord injury, among others."

The article, entitled "Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages," will be available online May 1, 2008, at: http://www.stemcells.com/papbyrecent.dtl .

About AlphaMed Press

AlphaMed Press publishes the internationally renowned journals, "Stem Cells" and "The Oncologist." "Stem Cells," now in its 26th year, is the oldest and one of the world's top-tier peer-reviewed monthly journals in the fast-paced area of stem cells and regenerative medicine. "The Oncologist," in its 13th year, is a premier peer-reviewed monthly journal dedica
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