Navigation Links
Mouse Adult Stem Cells Developed into Heart and Blood Cells
Date:4/30/2008

Key Step toward Clinical Testing of Stem Cells Developed from Patients'

Skin Cells

DURHAM, N.C., April 30 /PRNewswire/ -- Researchers have succeeded in inducing stem cells grown from mouse skin cells to differentiate into functioning cardiovascular and blood cells, according to a study publishing online tomorrow in the journal "Stem Cells."

(Logo: http://www.newscom.com/cgi-bin/prnh/20080422/CLTU133LOGO-a )

"Induced pluripotent stem (iPS) cells are reprogrammed cells obtained by genetic manipulation of normal adult cells that then express capabilities similar to embryonic stem cells," explains Dr. Miodrag Stojkovic, Co-Editor of "Stem Cells." "That is, iPS cells are theoretically able to differentiate into 220 different cell types. For the first time, scientists from UCLA were able to induce the differentiation of mouse iPS cells into functional heart cells, smooth muscle cells, and blood cells."

Katja Schenke-Layland and colleagues at UCLA performed a series of experiments using mouse iPS cells, using reprogrammed cells obtained from skin biopsies in adult mice. Although iPS cells are believed to be equivalent to embryonic stem cells, rigorous scientific studies are needed to confirm their potential to differentiate into specific types of cells.

Experiments in mice using iPS cells confirmed that the stem cells had differentiated into mature heart muscle cells (cardiomyocytes) and vascular smooth muscle cells (the specialized muscle cells lining the blood vessel walls). In addition, studies of cultured iPS cells showed markers characteristic of early cardiovascular and hematopoietic (blood-forming) cells. The iPS cells were essentially the same as mouse embryonic stem cells at the same stage of differentiation.

Using relatively simple laboratory techniques, the researchers were then able to induce iPS cells to develop into functional cardiomyocytes, smooth muscle cells, and hematopoietic cells. The functional cells showed only minor differences from cells developed from embryonic stem cells.

The ability to generate stem cells using the patient's own cells holds great promise for the treatment of currently incurable degenerative diseases, as well as for cell-based drug discovery. In recent months, reports from UCLA and other research groups have shown that human skin cells can be reprogrammed into cells that are nearly identical to human embryonic stem cells, without the need to use human embryos or eggs.

The new results are an important milestone, extensively documenting the capability of inducing mouse iPS cells to develop into different types of functional cells. The next step will be to develop efficient, reliable, and safe techniques of generating human cardiovascular and hematopoietic cells for use in testing new "patient-tailored regenerative therapies," the researchers write.

Dr. Stojkovic adds, "The development of functional cells from iPS is a key step forward in the development of patient-specific embryonic stem cells for use in developing new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and spinal cord injury, among others."

The article, entitled "Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages," will be available online May 1, 2008, at: http://www.stemcells.com/papbyrecent.dtl .

About AlphaMed Press

AlphaMed Press publishes the internationally renowned journals, "Stem Cells" and "The Oncologist." "Stem Cells," now in its 26th year, is the oldest and one of the world's top-tier peer-reviewed monthly journals in the fast-paced area of stem cells and regenerative medicine. "The Oncologist," in its 13th year, is a premier peer-reviewed monthly journal dedicated to physicians entrusted with the care of cancer patients. View AlphaMed Press journals at http://www.alphamedpress.org .

Contacts (please direct questions related to content to the corresponding author):
STEM CELLS' Editorial Office/Communications: Corresponding Author:

George Kendall, GKendall@alphamedpress.com W. Robb MacLellan,

Phone: 919-680-0011 (Ext. 224) rmaclellan@mednet.ucla.edu

Cardiovascular

STEM CELLS' Co-Editor: Research Laboratory,

Professor Miodrag Stojkovic, University of California

mstojkovic@cipf.es Los Angeles School

Phone: +381 63 768 6185 of Medicine

Phone: 310-825-2556


'/>"/>
SOURCE AlphaMed Press
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Mature Mouse Cells Reprogrammed to Stem Cell-Like State
2. Boston College biologists build a better mouse model for cancer research
3. Mouse model for mesothelioma reproduces human disease
4. Mouse study: Real-time imaging device may improve surgery for congenital colon disease
5. Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
6. Mouse Model of Age-Related Macular Degeneration Developed
7. Gene Tweak Reverses Aging in Mouse Skin Cells
8. A longer-living, healthier mouse that could hold clues to human aging
9. Mouse mammary tumor virus can replicate in human cells
10. Mouse Study Gives Clues to Colitis
11. Mouse vision has a rhythm all its own
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: