Navigation Links
Mount Sinai's Arvin Dar, Ph.D., receives NIH New Innovator Award for drug development

Arvin Dar, PhD, structural and chemical biologist in oncological sciences at the Icahn School of Medicine at Mount Sinai, is one of 41 national recipients of the prestigious National Institutes of Health (NIH) Director's New Innovator Awards for High-Risk, High Reward Research. The award will support Dar's research into Ras-dependent cancers, specifically investigating how to combat mutations in Ras, a protein implicated in at least one of every five cancers.

Even though Ras mutations have long been known as critical drivers of cancer, metastasis, and resistance to chemotherapy, drug development in this area has been dissappointing. It turns out that the structural biology underlying Ras mutations is extremely complex.

Dr. Dar, along with other researchers at the Icahn School of Medicine at Mount Sinai and the University of California San Francisco have been instrumental in advancing this research.

Dr. Dar's laboratory has been investigating new targets or strategies that show promise in interrupting the Ras pathway. The work is highly interdisciplinary, incorporating methods from synthetic organic chemistry, mass spectrometry, informatics, biochemistry, and model organism genetics. The eventual goal is to produce new classes of small molecule drugs that impede cancers.

"NIH is excited to support visionary investigators," said NIH Director Francis S. Collins, MD, PhD. This research has "the potential to transform scientific fields and accelerate the translation of scientific research into improved health."

The NIH Common Fund, in partnership with other NIH Institutes, are key backers of the NIH Director's New Innovators Fund. These programs are designed to overcome major research barriers, specifically catalyzing disease-specific research.

In accepting the award, Dr. Dar said: "It is truly an honor to be included in this year's recipients as it is a highly competitive funding mechanism. I have benefited greatly from support and mentorship of Mount Sinai faculty, including Stuart Aaronson and Ross Cagan, as well as my postdoctoral advisor, Kevan Shokat, at the University of California San Francisco. My previous work with them has led to a compound that is currently progressing towards a human clinical trial, and this new funding will allow us to explore new avenues in drug therapy."

Thirty years ago, Mount Sinai researchers played a pivotal role in first discovering Ras mutations, and their relationship to cancer biology. Stuart Aaronson, PhD, and Prem Reddy, PhD, made significant inroads in uncovering Ras mutations.


Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Related medicine news :

1. Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Mounting Claims Involving Risperdal Gynecomastia Allegations in Pennsylvania Litigation
2. Lipitor Lawsuits Continue to Mount, as Bernstein Liebhard LLP Notes Filing of New Claim Alleging an Association Between Lipitor and Diabetes
3. Mount Sinai's Novel Gene Therapy Works to Reverse Heart Failure
4. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
5. Mount Sinai Dermatology Department in NY Opens New Practice in Chinatown
6. Pradaxa Lawsuits Continue to Mount, With Filing of New Pradaxa Wrongful Death Claim in Pennsylvania by Wright & Schulte LLC
7. National Association of Professional Women Announces Elizabeth C. Abel, M.S.W., Project Director, CAPP of City of Mount Vernon-Youth Bureau, as VIP Woman of the Year
8. Newcastle, Oklahoma High School Provides Football Team with Brain Sentry Impact Sensor, Helmet-Mounted Device Helps ID Players Who Need to be Evaluated for Concussion
9. Peter R. Dottino, MD to Head Division of Gynecologic Oncology at Mount Sinai
10. Mirena Lawsuits Mount, as Bernstein Liebhard LLP Notes More than 400 Mirena IUD Lawsuit Filings in State, Federal Litigations
11. Mount Sinai and the Atlantic Host Working Summit on Big Data in New York City
Post Your Comments:
(Date:11/27/2015)... ... 27, 2015 , ... The men and women on this ... in the country. They have overseen financial turnarounds, shown commitment to their community ... industry as a whole through their advocacy and professional efforts. , Becker's Hospital ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft Inc., developer ... incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite 5.10 product ... Q-Suite 5.10 up-to-date with a version of Asterisk that will receive not only ...
(Date:11/26/2015)... Cambridge, ON (PRWEB) , ... November 26, 2015 ... ... availability of a real-time eReferral system for diagnostic imaging in the Waterloo region. ... mammography, BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) ...
(Date:11/26/2015)... NE (PRWEB) , ... November 26, 2015 , ... Jobs ... searched by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group ... during the month of October 2015 among those searching for healthcare jobs through the ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel Film Studios ... titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with 30 all-new ... any font, giving users limitless opportunities to stylize and create designs quickly and ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... "Radioimmunoassay Market by Type (Reagents & ... Academics, Clinical Diagnostic Labs), Application (Research, Clinical ... 2020" report to their offering. ... addition of the "Radioimmunoassay Market by ...
(Date:11/25/2015)... ) ... "Global Brain Monitoring Devices Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:11/25/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced ... the United States (U.S.) Food ... candidate to Humira ® (adalimumab). Amgen believes this ... the FDA and represents Amgen,s first BLA submission using ... , M.D., executive vice president of Research and Development ...
Breaking Medicine Technology: