(New York UNDER EMBARGO May 31, 2014) Icahn School of Medicine at Mount Sinai researchers will present several landmark studies at the 2014 American Society of Clinical Oncology (ASCO) meeting May 30-June 3, 2014 in Chicago, including data on new treatment approaches for thyroid, head and neck, and recurrent ovarian cancers; and new biomarkers for bile duct cancers.
Highlights of Mount Sinai research at ASCO:
In a study led by Amy Tiersten, MD, Associate Professor in the Division of Hematology and Medical Oncology and a member of the Breast Cancer Medical Oncology Program, Icahn School of Medicine at Mount Sinai, the efficacy and safety of Bevacizumab and Irinotecan in patients with recurrent ovarian cancer was observed. Researchers sought to determine how well this combination worked during and after 6 months of treatment, and to estimate the length of time the cancer did not get worse. Secondary objectives were to discover overall survival, observed response rate, duration of response, and toxicity. Of the 24 patients continuing in the study, 8 experienced a partial response, 13 remained stable with no progression of the disease and 3 progressed in their disease. The observed response rate was 27.6%, and the clinical benefit rate was 72.4%. Twelve patients had longer than 6 months of sustained response, and the median disease progression free response rate was 8.1 months. Adverse events were within the known side effects, with the most common being diarrhea, and no treatment-related deaths were observed.
"Our findings give hope to women with recurrent, advanced-stage ovarian cancer. The combination showed encouraging results in heavily-pretreated patients with this recurrent disease," said Dr. Tiersten. "This trial proves the effectiveness of this combination, and provided valuable information on the management of side effects."
In a study led by Randall Holcombe, MD, Professor of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, distinct biomarker features in bile duct and gallbladder cancers were discovered. A total of 643 (291 intrahepatic bile duct cancer; 115 extrahepatic bile duct cancer; 237 gallbladder cancer) cases were evaluated, diagnosis collected from referring physicians, and cancers classified at intake based on pathology and clinical history. Using comprehensive biomarker analysis including protein expression and gene sequencing and amplification, researchers identified 16 gene mutations out of 45 genes. Findings suggest effective treatments for these rare and often fatal diseases may be developed.
"The genetic mutations identified suggests potential targeted treatments in each cancer studied," said Dr. Holcombe. "This will give clinicians tailored treatment options for patients with a rare form of cancer."
In a study led by researcher Rachel Sabado, PhD, Assistant Professor of Medicine, Division of Hematology and Oncology at the Icahn School of Medicine at Mount Sinai, the safety and immunogenicity of vaccination with NY-ESO-1 protein emulsified in Montanide ISA-51 VG was given with or without Resiquimod in surgically resected stage 11B-1V melanoma patients. The results of the study show that Resiquimod is safe and contributes to the induction of immune responses in patients.
"The results of the study should prove very useful for future efforts to generate more potent cancer vaccines and provide attractive treatment alternatives for patients with a variety of NY-ESO-1 expressing cancers including melanoma for which treatment options remain limited," said Dr. Sabado.
|Contact: Lucia Lee|
The Mount Sinai Hospital / Mount Sinai School of Medicine