Navigation Links
Mount Sinai researchers succeed in programming blood forming stem cells
Date:6/13/2013

(New York, NY June 13, 2013)--By transferring four genes into mouse fibroblast cells, researchers at the Icahn School of Medicine at Mount Sinai have produced cells that resemble hematopoietic stem cells, which produce millions of new blood cells in the human body every day. These findings provide a platform for future development of patient-specific stem/progenitor cells, and more differentiated blood products, for cell-replacement therapy.

The study, titled, "Induction of a Hemogenic Program in Mouse Fibroblasts," was published online in CELL STEM CELL on June 13. Mount Sinai researchers screened a panel of 18 genetic factors for inducing blood-forming activity and identified a combination of four transcription factors, Gata2, Gfi1b, cFos, and Etv6 as sufficient to generate blood vessel precursor cells with the subsequent appearance of hematopoietic cells. The precursor cells express a human CD34 reporter, Sca1 and Prominin1 within a global endothelial transcription program.

"The cells that we grew in a petri dish are identical in gene expression to those found in the mouse embryo and could eventually generate colonies of mature blood cells," said the first author of the study, Carlos Filipe Pereira, PhD, Postdoctoral Fellow of Developmental and Regenerative Biology at the Icahn School of Medicine.

Other leaders of the research team that screened the genetic factors to find the right combination included Kateri Moore, DVM, Associate Professor of Developmental and Regenerative Biology at the Icahn School and Ihor R. Lemischka, PhD, Professor of Developmental and Regenerative Biology, Pharmacology and Systems Therapeutics and Director of The Black Family Stem Cell Institute at The Mount Sinai Medical Center.

"The combination of gene factors that we used was not composed entirely of the most obvious or expected proteins," said Dr. Lemischka. "Many investigators have been trying to grow hematopoietic stem cells from embry
'/>"/>

Contact: Renatt Brodsky
Renatt.Brodsky@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
2. Great recession reflux amounts to more hunger among seniors
3. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
4. Mount Sinai researchers develop a multi-target approach to treating tumors
5. Mount Sinai is first in New York state to perform new Alzheimers imaging test in clinical setting
6. Limited amounts of alcohol during pregnancy do not harm children
7. Mount Sinai researcher finds timing of ADHD medication affect academic progress
8. Americans Already Consuming the Right Amount of Salt
9. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
10. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
11. Is acetazolamide effective and safe for preventing acute mountain sickness?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Connie Casad, MD, a well-known and respected gynecologist, ... years of practice experience in Dallas, Texas, has announced ... dietary detoxification. The second study is scheduled to begin ... test patients who just completed a 21-day detoxification regimen. ... conducting the study, Dr. Casad said, "About 10 years ...
(Date:12/24/2014)... 2014 The federal court overseeing ... blood thinner caused life-threatening episodes of internal bleeding ... for the proceeding, Bernstein Liebhard LLP reports. According ... plans to select lawyers to serve as Liaison ... appointing a Plaintiffs’ Steering Committee, which will coordinate ...
(Date:12/24/2014)... (PRWEB) December 25, 2014 BambooIndustry.com a ... for many years. Today, the company announces its ... a special offer on these new products. , Bamboo ... renewable bamboo. The multiple layer bamboo panel board features ... both strong and emissions free. The bamboo panel consists ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- Adults who ... risk of migraine headaches, suggests a study published ... . "Childhood maltreatment can have long-lasting effects, ... in adulthood," study author Dawn Buse, director of ... York City, said in a journal news release. ...
(Date:12/24/2014)... 2014 Gluten, a protein found predominately ... have an intolerance to gluten, causing side effects that ... headaches, joint pain and fatigue. For this reason, Diet ... that deliver safe and fast weight loss while teaching ... gluten allergy reaction. These gluten free diet plans combine ...
Breaking Medicine News(10 mins):Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 3Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2Health News:Abuse in Childhood Tied to Migraines in Adulthood 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 3
... locking self locking fasteners are helping the electrical industry combat vibration ... design innovation. , ... (PRWEB) July 2, 2008 -- ... in soft materials prone to stripping or joint failure, self ...
... caring begun 29,years ago by a small group of friends ... fundraisers, thanks to the enthusiastic support of,women who see the ... The 29th annual Twilight Gathering, hosted by the Women,s ... p.m. at the home,of WCP President Carol Walters in Milford. ...
... Enthusiasm for event grows in the face of widespread budget cuts ... Area HIV/AIDS service ... Foundation,and AIDS Walk San Francisco announced today that the number of ... in,Golden Gate Park, July 20th, will expand from 42 to more ...
... Delaying childbirth has substantially contributed to recent rises in ... week by scientists at Cambridge University. , The findings ... Scottish data performed by a team under Professor Gordon ... , The team examined more than 500,000 entries ...
... help treat patients with cancer, depression, drug abuse, study ... spiritual effects of a substance in "sacred mushrooms" can ... , The scientists said their investigations may lead to ... cancer, depression and drug dependence. , In a previous ...
... Inc.,(Nasdaq: SUPG ), a pharmaceutical company dedicated ... for solid tumors and,hematological malignancies, today announced that ... is scheduled to present at the,Collins Stewart Growth ... Oriental Hotel in New York City., SuperGen,s ...
Cached Medicine News:Health News:Innovative Self Locking Threaded Fasteners Provide New Electrical Design Options 2Health News:Area Women Gather in Milford on July 10 to Further the Mission of Women's Caring Program 2Health News:AIDS Walk San Francisco Boosts Number of Teams and Benefiting Agencies 2Health News:AIDS Walk San Francisco Boosts Number of Teams and Benefiting Agencies 3Health News:Major rise in Caesarean sections linked to impaired womb function with age 2Health News:Hallucinogen Gives Lasting Spiritual Boost 2Health News:SuperGen to Present at the Collins Stewart Growth Conference on July 9, 2008 2
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
(Date:12/24/2014)... 2014 LifeScienceIndustryResearch.com adds ... Syringe Industry of 178 pages providing 10 ... library. The 2014 Market Research ... a professional and deep research report on ... the report introduces Disposable Syringe basic information ...
(Date:12/24/2014)... , Dec. 23, 2014  Lockton Dunning ... of Lockton Companies, announced the addition of Vice ... will join Lockton Dunning,s Pharmacy Consulting team, Excelsior ... of relevant industry experience to the position.  Most ... Market Sales at Diplomat Specialty Pharmacy, where she ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Kim Foerster Joins Lockton Companies 2
... June 19 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS; Nasdaq: PXSL) ... Food,and Drug Administration (FDA) have reached agreement on ... via the Special,Protocol Assessment process., The SPA ... trial protocol,intended to form the primary basis of ...
... KNDL ), a,leading global full-service clinical research organization ... present at the upcoming Drug,Information Association (DIA) 44th ... 2008, at the Boston Convention and Exhibition Center ... topics in the clinical,development industry, including EDC, biomarkers, ...
Cached Medicine Technology:Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial 2Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial 3Kendle Experts to Present at the Drug Information Association 44th Annual Meeting 2Kendle Experts to Present at the Drug Information Association 44th Annual Meeting 3
Adjust-A-Tip cautery....
Thru cut kerrison style punch 30 deg, 2.75 X 1.4 mm cut, 110 working length....
3 mm, 130 degree upwards cutting, detachable....
Sabre 180 is a powerful niche generator....
Medicine Products: