Navigation Links
Mount Sinai researchers move closer to a universal influenza vaccine
Date:5/25/2010

Researchers at Mount Sinai School of Medicine have developed a new influenza vaccine that brings science one step closer to a universal influenza vaccine that would eliminate the need for seasonal flu shots. The new findings can be found in the inaugural issue of mBio, the first online, open-access journal published by the American Society for Microbiology.

"Current influenza vaccines are effective against only a narrow range of influenza virus strains," said Peter Palese, Ph.D., Professor and Chair of the Department of Microbiology at Mount Sinai School of Medicine. "This new vaccine brings us closer to our ultimate goal of a vaccine that protects against multiple strains."

The current seasonal influenza vaccine is strain-specific, targeting the globular head of the hemaglutinin (HA) molecule on the surface of the influenza virus. This globular head is highly variable and constantly changing from strain to strain. Each flu season presents a different strain, making it necessary to adjust the vaccine each year.

In the new study, Dr. Palese and his colleagues developed a vaccine using HA without its globular head. Mice were injected with the vaccine and then following challenge were monitored for morbidity and mortality daily for 10 days. All of the mice vaccinated with the headless HA vaccine survived, while all unvaccinated mice died. Mount Sinai School of Medicine has submitted a patent application for this vaccine approach.

"Our results suggest that the response induced by this vaccine is potent enough to warrant further development toward a universal influenza virus vaccine," said Dr. Palese. "With further development and testing, we predict that a single immunization will in the future offer a sufficient defense against several influenza epidemics."


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
2. Flat Screen TV Stands, TV Mounting Brackets and More: New Site, New Sale, Free Shipping
3. Mountain Home Experiences a Huge Response to Their Ground Breaking Free Lean Six Sigma Certification Offer
4. UniCare, Walmart Organize Circle of Hope To Help Mountain Mission Meet Increased Demand for Assistance
5. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
6. Childhood obesity: Its not the amount of TV, its the number of junk food commercials
7. New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget
8. Mountain Home 'Doing the Right Thing Really is the Best Business Approach'
9. Dominos Pizza(R) Raises Record Amount for St. Jude Childrens Research Hospital
10. Excitement Surrounding "Unveil Your Pink" Mounts!
11. Connecticut Governor Jodi Rell Honors Mountainside Addiction Treatment Center for its Twelve Years of Operating in Connecticut
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: