Navigation Links
Mount Sinai researchers move closer to a universal influenza vaccine
Date:5/25/2010

Researchers at Mount Sinai School of Medicine have developed a new influenza vaccine that brings science one step closer to a universal influenza vaccine that would eliminate the need for seasonal flu shots. The new findings can be found in the inaugural issue of mBio, the first online, open-access journal published by the American Society for Microbiology.

"Current influenza vaccines are effective against only a narrow range of influenza virus strains," said Peter Palese, Ph.D., Professor and Chair of the Department of Microbiology at Mount Sinai School of Medicine. "This new vaccine brings us closer to our ultimate goal of a vaccine that protects against multiple strains."

The current seasonal influenza vaccine is strain-specific, targeting the globular head of the hemaglutinin (HA) molecule on the surface of the influenza virus. This globular head is highly variable and constantly changing from strain to strain. Each flu season presents a different strain, making it necessary to adjust the vaccine each year.

In the new study, Dr. Palese and his colleagues developed a vaccine using HA without its globular head. Mice were injected with the vaccine and then following challenge were monitored for morbidity and mortality daily for 10 days. All of the mice vaccinated with the headless HA vaccine survived, while all unvaccinated mice died. Mount Sinai School of Medicine has submitted a patent application for this vaccine approach.

"Our results suggest that the response induced by this vaccine is potent enough to warrant further development toward a universal influenza virus vaccine," said Dr. Palese. "With further development and testing, we predict that a single immunization will in the future offer a sufficient defense against several influenza epidemics."


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
2. Flat Screen TV Stands, TV Mounting Brackets and More: New Site, New Sale, Free Shipping
3. Mountain Home Experiences a Huge Response to Their Ground Breaking Free Lean Six Sigma Certification Offer
4. UniCare, Walmart Organize Circle of Hope To Help Mountain Mission Meet Increased Demand for Assistance
5. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
6. Childhood obesity: Its not the amount of TV, its the number of junk food commercials
7. New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget
8. Mountain Home 'Doing the Right Thing Really is the Best Business Approach'
9. Dominos Pizza(R) Raises Record Amount for St. Jude Childrens Research Hospital
10. Excitement Surrounding "Unveil Your Pink" Mounts!
11. Connecticut Governor Jodi Rell Honors Mountainside Addiction Treatment Center for its Twelve Years of Operating in Connecticut
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
Breaking Medicine Technology: