Navigation Links
Mount Sinai researchers find new target to improve pain management
Date:9/7/2010

Researchers from Mount Sinai School of Medicine have discovered a major mechanism underlying the development of tolerance to chronic morphine treatment. The discovery may help researchers find new therapies to treat chronic pain, and reduce tolerance and side effects associated with morphine use. The findings are published in the July 20th issue of Science Signaling.

Overcoming tolerance to morphine after chronic administration has been a persistent problem in treating patients with severe pain, including those with cancer and neuropathy and recovering from major surgeries. After a week of morphine use, its effectiveness decreases as patients build tolerance, and patients also experience negative side effects like addiction and constipation. Researchers at Mount Sinai have identified changes in the brain and spinal cord that occur during the development of morphine tolerance, providing a therapeutic target for preventing it and allowing for the identification of new therapies to treat pain with fewer side effects.

Led by Lakshmi Devi, PhD, Professor of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, the research team studied changes in the abundance and signaling properties of a protein complex containing two different types of opioid receptors in the brains of mice. The protein complex, called a heterodimer, is made up of the mu receptor and one other opioid receptor called the delta receptor. After using a clever strategy to develop selective antibodies for the detection of the heterodimer in vivo, they found that this protein complex excessively accumulates in areas of the brain that process pain. Previous studies from Dr. Devi's lab have shown that signaling through this complex is associated with a reduced responsiveness to morphine over five days of treatment. Therefore, it is likely that the accumulation of this complex in pain-processing brain regions may be the cause of the development of morphine tolerance.

"We found that the brain selectively responds to chronic morphine by increasing heteromer abundance, blocking individual receptors from signaling the analgesic response to morphine," said Dr. Devi. "Now that we have identified a signaling complex associated with morphine tolerance, we can develop a drug that will block the delta receptor within this complex, allowing the mu receptor to signal for pain reduction." Dr. Devi's team will also work to find a drug that binds to the mu-delta receptor complex so that they can study how this receptor complex presents itself in other diseases as well.

"This finding may apply to more than just opiates," continued Dr. Devi. "We look forward to studying the behavior of similar receptor complexes in diseases like obesity, alcohol-induced liver fibrosis, and neuropathic pain itself."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Small Amounts of Dark Chocolate May Guard Against Heart Failure
2. Mount Sinai pioneers new cardiac imaging device
3. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
4. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
5. Chicago Father and Son Team to Climb Mount Kilimanjaro for ShelterBox
6. AAU Big Mountain Jam Basketball Tournament To Be Played On SnapSports Flooring
7. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
8. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
9. Albeo Releases Six New Surface Mount LED Lighting Fixtures
10. Green Drinks NYC and Green Mountain Energy Company Present Summer Bash at Solar One
11. The Mount Sinai Hospital Ranked in Top 25 of Best Children's Hospitals in Two Specialties by U.S. News & World Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... ... ... With the increasing public preference for chemical-free personal care ... for customers who have grown more conscious about maintaining their health and wellness. ... products, Moody Zook Chief Executive Officer Nate Ginsburg explained their company’s decision to ...
(Date:1/13/2017)... ... 13, 2017 , ... An inventor from Virginia Beach, Va., is always on ... to diversify my outfits, so he decided to design something that enhances the look ... appearance of a belt to allow for quick, easy changing of its look. This ...
(Date:1/13/2017)... ... January 13, 2017 , ... "We wanted to create a ... said one of two inventors from Virginia Beach, Va. , They created a prototype ... , The accessories allow braces to be customized to suit personal tastes. They ...
(Date:1/13/2017)... ... January 13, 2017 , ... On January 11th, ... Cokato, MN, with the official send-off from Orchestra Hall in Minneapolis on Saturday, ... Minnesota Orchestra’s Music Director, leading the official launch of the sauna. After leaving ...
(Date:1/13/2017)... , ... January 13, 2017 , ... ... the world’s first and most comprehensive franchise ranking. Recognized by entrepreneurs and franchisors ... 129 for its exceptional performance in areas including financial strength and stability, growth ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... , Jan. 12, 2017   JDRF ... diabetes (T1D) research, is pleased to announce that ... the Centers for Medicare & Medicaid Services (CMS) ... by the FDA for use in making diabetes ... step toward making them eligible for coverage under ...
(Date:1/13/2017)... YORK , Jan. 12, 2017  Rosen Law ... filing of a class action lawsuit on behalf of ... ALXN ) from February 10, 2014 through November 9, ... recover damages for Alexion investors under the federal securities ... go to http://rosenlegal.com/cases-991.html or call Phillip ...
(Date:1/13/2017)... 2017  Biologics Prescribers Collaborative (BPC) applauds ... for issuing final guidance calling for distinguishable ... is an important win for patients and ... pharmacovigilance, patient safety and transparency. ... FDA, we remain concerned with "random" suffixes called for ...
Breaking Medicine Technology: